Toward biomedical application of amino-functionalized silicon nanoparticles
Silicon blue-emitting nanoparticles (NPs) are promising effectors for photodynamic therapy and radiotherapy, because of their production of reactive oxygen species (ROS) upon irradiation. Results: Amino-functionalized silicon NPs (NH2SiNP) were intrinsically nontoxic below 100 μg/ml in vitro (on two...
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2018
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_17435889_v13_n11_p1349_Lillo http://hdl.handle.net/20.500.12110/paper_17435889_v13_n11_p1349_Lillo |
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paper:paper_17435889_v13_n11_p1349_Lillo2023-06-08T16:27:54Z Toward biomedical application of amino-functionalized silicon nanoparticles PDT radiotherapy silicon nanoparticles skin penetration ultradeformable liposomes zebrafish amino functionalized silicon nanoparticle liposome nanoparticle photosensitizing agent reactive oxygen metabolite unclassified drug liposome nanoparticle photosensitizing agent silicon adult animal cell Article cell viability controlled study cytotoxicity drug delivery system embryo epidermis female human human cell human tissue in vitro study in vivo study incubation time nanoencapsulation nonhuman particle size photodynamic therapy priority journal radiotherapy rat skin penetration tumor cell line zebra fish animal cell survival chemistry drug delivery system drug effect growth, development and aging metabolism photochemotherapy Animals Cell Survival Drug Delivery Systems Humans Liposomes Nanoparticles Photochemotherapy Photosensitizing Agents Reactive Oxygen Species Silicon Zebrafish Silicon blue-emitting nanoparticles (NPs) are promising effectors for photodynamic therapy and radiotherapy, because of their production of reactive oxygen species (ROS) upon irradiation. Results: Amino-functionalized silicon NPs (NH2SiNP) were intrinsically nontoxic below 100 μg/ml in vitro (on two tumor cell lines) and in vivo (zebrafish larvae and embryos). NH2SiNP showed a moderate effect as a photosensitizer for photodynamic therapy and reduced ROS generation in radiotherapy, which could be indicative of a ROS scavenging effect. Encapsulation of NH2SiNP into ultradeformable liposomes improved their skin penetration after topical application, reaching the viable epidermis where neoplastic events occur. Conclusion: Subsequent derivatizations after amino-functionalization and incorporation to nanodrug delivery systems could expand the spectrum of the biomedical application of these kind of silicon NPs. © 2018 Future Medicine Ltd. 2018 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_17435889_v13_n11_p1349_Lillo http://hdl.handle.net/20.500.12110/paper_17435889_v13_n11_p1349_Lillo |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
PDT radiotherapy silicon nanoparticles skin penetration ultradeformable liposomes zebrafish amino functionalized silicon nanoparticle liposome nanoparticle photosensitizing agent reactive oxygen metabolite unclassified drug liposome nanoparticle photosensitizing agent silicon adult animal cell Article cell viability controlled study cytotoxicity drug delivery system embryo epidermis female human human cell human tissue in vitro study in vivo study incubation time nanoencapsulation nonhuman particle size photodynamic therapy priority journal radiotherapy rat skin penetration tumor cell line zebra fish animal cell survival chemistry drug delivery system drug effect growth, development and aging metabolism photochemotherapy Animals Cell Survival Drug Delivery Systems Humans Liposomes Nanoparticles Photochemotherapy Photosensitizing Agents Reactive Oxygen Species Silicon Zebrafish |
| spellingShingle |
PDT radiotherapy silicon nanoparticles skin penetration ultradeformable liposomes zebrafish amino functionalized silicon nanoparticle liposome nanoparticle photosensitizing agent reactive oxygen metabolite unclassified drug liposome nanoparticle photosensitizing agent silicon adult animal cell Article cell viability controlled study cytotoxicity drug delivery system embryo epidermis female human human cell human tissue in vitro study in vivo study incubation time nanoencapsulation nonhuman particle size photodynamic therapy priority journal radiotherapy rat skin penetration tumor cell line zebra fish animal cell survival chemistry drug delivery system drug effect growth, development and aging metabolism photochemotherapy Animals Cell Survival Drug Delivery Systems Humans Liposomes Nanoparticles Photochemotherapy Photosensitizing Agents Reactive Oxygen Species Silicon Zebrafish Toward biomedical application of amino-functionalized silicon nanoparticles |
| topic_facet |
PDT radiotherapy silicon nanoparticles skin penetration ultradeformable liposomes zebrafish amino functionalized silicon nanoparticle liposome nanoparticle photosensitizing agent reactive oxygen metabolite unclassified drug liposome nanoparticle photosensitizing agent silicon adult animal cell Article cell viability controlled study cytotoxicity drug delivery system embryo epidermis female human human cell human tissue in vitro study in vivo study incubation time nanoencapsulation nonhuman particle size photodynamic therapy priority journal radiotherapy rat skin penetration tumor cell line zebra fish animal cell survival chemistry drug delivery system drug effect growth, development and aging metabolism photochemotherapy Animals Cell Survival Drug Delivery Systems Humans Liposomes Nanoparticles Photochemotherapy Photosensitizing Agents Reactive Oxygen Species Silicon Zebrafish |
| description |
Silicon blue-emitting nanoparticles (NPs) are promising effectors for photodynamic therapy and radiotherapy, because of their production of reactive oxygen species (ROS) upon irradiation. Results: Amino-functionalized silicon NPs (NH2SiNP) were intrinsically nontoxic below 100 μg/ml in vitro (on two tumor cell lines) and in vivo (zebrafish larvae and embryos). NH2SiNP showed a moderate effect as a photosensitizer for photodynamic therapy and reduced ROS generation in radiotherapy, which could be indicative of a ROS scavenging effect. Encapsulation of NH2SiNP into ultradeformable liposomes improved their skin penetration after topical application, reaching the viable epidermis where neoplastic events occur. Conclusion: Subsequent derivatizations after amino-functionalization and incorporation to nanodrug delivery systems could expand the spectrum of the biomedical application of these kind of silicon NPs. © 2018 Future Medicine Ltd. |
| title |
Toward biomedical application of amino-functionalized silicon nanoparticles |
| title_short |
Toward biomedical application of amino-functionalized silicon nanoparticles |
| title_full |
Toward biomedical application of amino-functionalized silicon nanoparticles |
| title_fullStr |
Toward biomedical application of amino-functionalized silicon nanoparticles |
| title_full_unstemmed |
Toward biomedical application of amino-functionalized silicon nanoparticles |
| title_sort |
toward biomedical application of amino-functionalized silicon nanoparticles |
| publishDate |
2018 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_17435889_v13_n11_p1349_Lillo http://hdl.handle.net/20.500.12110/paper_17435889_v13_n11_p1349_Lillo |
| _version_ |
1768545666618884096 |