Requirement of NF-kappa B activation in different mice brain areas during long-term memory consolidation in two contextual one-trial tasks with opposing valences

NF-kappa B is a transcription factor whose activation has been shown to be necessary for long-term memory consolidation in several species. NF-kappa B is activated and translocates to the nucleus of cells in a specific temporal window during consolidation. Our work focuses on a one trial learning ta...

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Detalles Bibliográficos
Publicado: 2017
Materias:
Amygdala
Hippocampus
Inhibitory avoidance learning
NF-kappa B
Nucleus accumbens
One-trial learning
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16625099_v10_n_p_Salles
http://hdl.handle.net/20.500.12110/paper_16625099_v10_n_p_Salles
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_16625099_v10_n_p_Salles
record_format dspace
spelling paper:paper_16625099_v10_n_p_Salles2023-06-08T16:25:45Z Requirement of NF-kappa B activation in different mice brain areas during long-term memory consolidation in two contextual one-trial tasks with opposing valences Amygdala Hippocampus Inhibitory avoidance learning NF-kappa B Nucleus accumbens One-trial learning NF-kappa B is a transcription factor whose activation has been shown to be necessary for long-term memory consolidation in several species. NF-kappa B is activated and translocates to the nucleus of cells in a specific temporal window during consolidation. Our work focuses on a one trial learning tasks associated to the inhibitory avoidance (IA) setting. Mice were trained either receiving or not a footshock when entering a dark compartment (aversive vs. appetitive learning). Regardless of training condition (appetitive or aversive), latencies to step-through during testing were significantly different to those measured during training. Additionally, these testing latencies were also different from those of a control group that only received a shock unrelated to context. Moreover, nuclear NF-kappa B DNA-binding activity was augmented in the aversive and the appetitive tasks when compared with control and naïve animals. NF-kappa B inhibition by Sulfasalazine injected either in the Hippocampus, Amygdala or Nucleus accumbens immediately after training was able to impair retention in both training versions. Our results suggest that NF-kappa B is a critical molecular step, in different brain areas on memory consolidation. This was the case for both the IA task and also the modified version of the same task where the footshock was omitted during training. This work aims to further investigate how appetitive and aversive memories are consolidated. © 2017 Salles, Krawczyk, Blake, Romano, Boccia and Freudenthal. 2017 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16625099_v10_n_p_Salles http://hdl.handle.net/20.500.12110/paper_16625099_v10_n_p_Salles
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Amygdala
Hippocampus
Inhibitory avoidance learning
NF-kappa B
Nucleus accumbens
One-trial learning
spellingShingle Amygdala
Hippocampus
Inhibitory avoidance learning
NF-kappa B
Nucleus accumbens
One-trial learning
Requirement of NF-kappa B activation in different mice brain areas during long-term memory consolidation in two contextual one-trial tasks with opposing valences
topic_facet Amygdala
Hippocampus
Inhibitory avoidance learning
NF-kappa B
Nucleus accumbens
One-trial learning
description NF-kappa B is a transcription factor whose activation has been shown to be necessary for long-term memory consolidation in several species. NF-kappa B is activated and translocates to the nucleus of cells in a specific temporal window during consolidation. Our work focuses on a one trial learning tasks associated to the inhibitory avoidance (IA) setting. Mice were trained either receiving or not a footshock when entering a dark compartment (aversive vs. appetitive learning). Regardless of training condition (appetitive or aversive), latencies to step-through during testing were significantly different to those measured during training. Additionally, these testing latencies were also different from those of a control group that only received a shock unrelated to context. Moreover, nuclear NF-kappa B DNA-binding activity was augmented in the aversive and the appetitive tasks when compared with control and naïve animals. NF-kappa B inhibition by Sulfasalazine injected either in the Hippocampus, Amygdala or Nucleus accumbens immediately after training was able to impair retention in both training versions. Our results suggest that NF-kappa B is a critical molecular step, in different brain areas on memory consolidation. This was the case for both the IA task and also the modified version of the same task where the footshock was omitted during training. This work aims to further investigate how appetitive and aversive memories are consolidated. © 2017 Salles, Krawczyk, Blake, Romano, Boccia and Freudenthal.
title Requirement of NF-kappa B activation in different mice brain areas during long-term memory consolidation in two contextual one-trial tasks with opposing valences
title_short Requirement of NF-kappa B activation in different mice brain areas during long-term memory consolidation in two contextual one-trial tasks with opposing valences
title_full Requirement of NF-kappa B activation in different mice brain areas during long-term memory consolidation in two contextual one-trial tasks with opposing valences
title_fullStr Requirement of NF-kappa B activation in different mice brain areas during long-term memory consolidation in two contextual one-trial tasks with opposing valences
title_full_unstemmed Requirement of NF-kappa B activation in different mice brain areas during long-term memory consolidation in two contextual one-trial tasks with opposing valences
title_sort requirement of nf-kappa b activation in different mice brain areas during long-term memory consolidation in two contextual one-trial tasks with opposing valences
publishDate 2017
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16625099_v10_n_p_Salles
http://hdl.handle.net/20.500.12110/paper_16625099_v10_n_p_Salles
_version_ 1768542053969428480

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