An antifungal tetrapeptide from the culture of Penicillium canescens

A new tetrapeptide D-Phe-L-Val-D-Val-L-Tyr (1), along with three known diketopiperazines and pseurotin A, were isolated from the culture of Penicillium canescens, collected from pollen from beehives, in a screening for new antimicrobial products from unexplored sources. The structure of the tetrapep...

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Autores principales:	Bertinetti, Brenda Verónica, Cabrera, Gabriela Myriam
Publicado:	2009
Materias:	benomyl dextro phenylalanylvalyl dextro valyltyrosine tetrapeptide unclassified drug antifungal activity antimicrobial activity article Bacillus subtilis Colletotrichum controlled study drug identification drug inhibition drug isolation drug screening drug structure Fusarium Fusarium lateritium Fusarium virguliforme nonhuman nuclear magnetic resonance Penicillium Penicillium canescens pollen Antifungal Agents Nuclear Magnetic Resonance, Biomolecular Oligopeptides Tandem Mass Spectrometry Glycine max
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16121872_v6_n8_p1178_Bertinetti http://hdl.handle.net/20.500.12110/paper_16121872_v6_n8_p1178_Bertinetti
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_16121872_v6_n8_p1178_Bertinetti
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spelling	paper:paper_16121872_v6_n8_p1178_Bertinetti2023-06-08T16:25:12Z An antifungal tetrapeptide from the culture of Penicillium canescens Bertinetti, Brenda Verónica Cabrera, Gabriela Myriam benomyl dextro phenylalanylvalyl dextro valyltyrosine tetrapeptide unclassified drug antifungal activity antimicrobial activity article Bacillus subtilis Colletotrichum controlled study drug identification drug inhibition drug isolation drug screening drug structure Fusarium Fusarium lateritium Fusarium virguliforme nonhuman nuclear magnetic resonance Penicillium Penicillium canescens pollen Antifungal Agents Fusarium Nuclear Magnetic Resonance, Biomolecular Oligopeptides Penicillium Tandem Mass Spectrometry Fusarium virguliforme Glycine max Penicillium canescens A new tetrapeptide D-Phe-L-Val-D-Val-L-Tyr (1), along with three known diketopiperazines and pseurotin A, were isolated from the culture of Penicillium canescens, collected from pollen from beehives, in a screening for new antimicrobial products from unexplored sources. The structure of the tetrapeptide, which exhibits antifungal activity comparable with that of the commercial product benomyl against the soybean phytopathogen Fusarium virguliforme, was determined by spectroscopic (2D-NMR, and MS and MS/MS) and chemical methods, and the sequence was confirmed by comparison with authentic synthetic isomeric peptides. © 2009 Verlag Helvetica Chimica Acta AG. Fil:Bertinetti, B.V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cabrera, G.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16121872_v6_n8_p1178_Bertinetti http://hdl.handle.net/20.500.12110/paper_16121872_v6_n8_p1178_Bertinetti
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	benomyl dextro phenylalanylvalyl dextro valyltyrosine tetrapeptide unclassified drug antifungal activity antimicrobial activity article Bacillus subtilis Colletotrichum controlled study drug identification drug inhibition drug isolation drug screening drug structure Fusarium Fusarium lateritium Fusarium virguliforme nonhuman nuclear magnetic resonance Penicillium Penicillium canescens pollen Antifungal Agents Fusarium Nuclear Magnetic Resonance, Biomolecular Oligopeptides Penicillium Tandem Mass Spectrometry Fusarium virguliforme Glycine max Penicillium canescens
spellingShingle	benomyl dextro phenylalanylvalyl dextro valyltyrosine tetrapeptide unclassified drug antifungal activity antimicrobial activity article Bacillus subtilis Colletotrichum controlled study drug identification drug inhibition drug isolation drug screening drug structure Fusarium Fusarium lateritium Fusarium virguliforme nonhuman nuclear magnetic resonance Penicillium Penicillium canescens pollen Antifungal Agents Fusarium Nuclear Magnetic Resonance, Biomolecular Oligopeptides Penicillium Tandem Mass Spectrometry Fusarium virguliforme Glycine max Penicillium canescens Bertinetti, Brenda Verónica Cabrera, Gabriela Myriam An antifungal tetrapeptide from the culture of Penicillium canescens
topic_facet	benomyl dextro phenylalanylvalyl dextro valyltyrosine tetrapeptide unclassified drug antifungal activity antimicrobial activity article Bacillus subtilis Colletotrichum controlled study drug identification drug inhibition drug isolation drug screening drug structure Fusarium Fusarium lateritium Fusarium virguliforme nonhuman nuclear magnetic resonance Penicillium Penicillium canescens pollen Antifungal Agents Fusarium Nuclear Magnetic Resonance, Biomolecular Oligopeptides Penicillium Tandem Mass Spectrometry Fusarium virguliforme Glycine max Penicillium canescens
description	A new tetrapeptide D-Phe-L-Val-D-Val-L-Tyr (1), along with three known diketopiperazines and pseurotin A, were isolated from the culture of Penicillium canescens, collected from pollen from beehives, in a screening for new antimicrobial products from unexplored sources. The structure of the tetrapeptide, which exhibits antifungal activity comparable with that of the commercial product benomyl against the soybean phytopathogen Fusarium virguliforme, was determined by spectroscopic (2D-NMR, and MS and MS/MS) and chemical methods, and the sequence was confirmed by comparison with authentic synthetic isomeric peptides. © 2009 Verlag Helvetica Chimica Acta AG.
author	Bertinetti, Brenda Verónica Cabrera, Gabriela Myriam
author_facet	Bertinetti, Brenda Verónica Cabrera, Gabriela Myriam
author_sort	Bertinetti, Brenda Verónica
title	An antifungal tetrapeptide from the culture of Penicillium canescens
title_short	An antifungal tetrapeptide from the culture of Penicillium canescens
title_full	An antifungal tetrapeptide from the culture of Penicillium canescens
title_fullStr	An antifungal tetrapeptide from the culture of Penicillium canescens
title_full_unstemmed	An antifungal tetrapeptide from the culture of Penicillium canescens
title_sort	antifungal tetrapeptide from the culture of penicillium canescens
publishDate	2009
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16121872_v6_n8_p1178_Bertinetti http://hdl.handle.net/20.500.12110/paper_16121872_v6_n8_p1178_Bertinetti
work_keys_str_mv	AT bertinettibrendaveronica anantifungaltetrapeptidefromthecultureofpenicilliumcanescens AT cabreragabrielamyriam anantifungaltetrapeptidefromthecultureofpenicilliumcanescens AT bertinettibrendaveronica antifungaltetrapeptidefromthecultureofpenicilliumcanescens AT cabreragabrielamyriam antifungaltetrapeptidefromthecultureofpenicilliumcanescens
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An antifungal tetrapeptide from the culture of Penicillium canescens

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