The benefits of analysing complete mitochondrial genomes: Deep insights into the phylogeny and population structure of Echinococcus granulosus sensu lato genotypes G6 and G7
Cystic echinococcosis (CE) is a zoonotic disease caused by the larval stage of the species complex Echinococcus granulosus sensu lato. Within this complex, genotypes G6 and G7 have been frequently associated with human CE worldwide. Previous studies exploring the genetic variability and phylogeograp...
Guardado en:
| Publicado: |
2018
|
|---|---|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15671348_v64_n_p85_Laurimae http://hdl.handle.net/20.500.12110/paper_15671348_v64_n_p85_Laurimae |
| Aporte de: |
| id |
paper:paper_15671348_v64_n_p85_Laurimae |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_15671348_v64_n_p85_Laurimae2023-06-08T16:24:00Z The benefits of analysing complete mitochondrial genomes: Deep insights into the phylogeny and population structure of Echinococcus granulosus sensu lato genotypes G6 and G7 Cystic echinococcosis Genotype G6 Genotype G7 Hydatid disease Mitochondrial genome Zoonosis cyclooxygenase 1 Article binding affinity Corsica Echinococcus granulosus Echinococcus granulosus sensu lato gene sequence gene structure genetic variability genetic variation genotype geographic mapping geography haplotype human life cycle mitochondrial genome Mongolia nonhuman phylogeny population differentiation population structure priority journal Sardinia sequence analysis Cystic echinococcosis (CE) is a zoonotic disease caused by the larval stage of the species complex Echinococcus granulosus sensu lato. Within this complex, genotypes G6 and G7 have been frequently associated with human CE worldwide. Previous studies exploring the genetic variability and phylogeography of genotypes G6 and G7 have been based on relatively short mtDNA sequences, and the resolution of these studies has often been low. Moreover, using short sequences, the distinction between G6 and G7 has in some cases remained challenging. The aim here was to sequence complete mitochondrial genomes (mitogenomes) to obtain deeper insight into the genetic diversity, phylogeny and population structure of genotypes G6 and G7. We sequenced complete mitogenomes of 94 samples collected from 15 different countries worldwide. The results demonstrated that (i) genotypes G6 and G7 can be clearly distinguished when mitogenome sequences are used; (ii) G7 is represented by two major haplogroups, G7a and G7b, the latter being specific to islands of Corsica and Sardinia; (iii) intensive animal trade, but also geographical isolation, have likely had the largest impact on shaping the genetic structure and distribution of genotypes G6 and G7. In addition, we found phylogenetically highly divergent haplotype from Mongolia (Gmon), which had a higher affinity to G6. © 2018 Elsevier B.V. 2018 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15671348_v64_n_p85_Laurimae http://hdl.handle.net/20.500.12110/paper_15671348_v64_n_p85_Laurimae |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cystic echinococcosis Genotype G6 Genotype G7 Hydatid disease Mitochondrial genome Zoonosis cyclooxygenase 1 Article binding affinity Corsica Echinococcus granulosus Echinococcus granulosus sensu lato gene sequence gene structure genetic variability genetic variation genotype geographic mapping geography haplotype human life cycle mitochondrial genome Mongolia nonhuman phylogeny population differentiation population structure priority journal Sardinia sequence analysis |
| spellingShingle |
Cystic echinococcosis Genotype G6 Genotype G7 Hydatid disease Mitochondrial genome Zoonosis cyclooxygenase 1 Article binding affinity Corsica Echinococcus granulosus Echinococcus granulosus sensu lato gene sequence gene structure genetic variability genetic variation genotype geographic mapping geography haplotype human life cycle mitochondrial genome Mongolia nonhuman phylogeny population differentiation population structure priority journal Sardinia sequence analysis The benefits of analysing complete mitochondrial genomes: Deep insights into the phylogeny and population structure of Echinococcus granulosus sensu lato genotypes G6 and G7 |
| topic_facet |
Cystic echinococcosis Genotype G6 Genotype G7 Hydatid disease Mitochondrial genome Zoonosis cyclooxygenase 1 Article binding affinity Corsica Echinococcus granulosus Echinococcus granulosus sensu lato gene sequence gene structure genetic variability genetic variation genotype geographic mapping geography haplotype human life cycle mitochondrial genome Mongolia nonhuman phylogeny population differentiation population structure priority journal Sardinia sequence analysis |
| description |
Cystic echinococcosis (CE) is a zoonotic disease caused by the larval stage of the species complex Echinococcus granulosus sensu lato. Within this complex, genotypes G6 and G7 have been frequently associated with human CE worldwide. Previous studies exploring the genetic variability and phylogeography of genotypes G6 and G7 have been based on relatively short mtDNA sequences, and the resolution of these studies has often been low. Moreover, using short sequences, the distinction between G6 and G7 has in some cases remained challenging. The aim here was to sequence complete mitochondrial genomes (mitogenomes) to obtain deeper insight into the genetic diversity, phylogeny and population structure of genotypes G6 and G7. We sequenced complete mitogenomes of 94 samples collected from 15 different countries worldwide. The results demonstrated that (i) genotypes G6 and G7 can be clearly distinguished when mitogenome sequences are used; (ii) G7 is represented by two major haplogroups, G7a and G7b, the latter being specific to islands of Corsica and Sardinia; (iii) intensive animal trade, but also geographical isolation, have likely had the largest impact on shaping the genetic structure and distribution of genotypes G6 and G7. In addition, we found phylogenetically highly divergent haplotype from Mongolia (Gmon), which had a higher affinity to G6. © 2018 Elsevier B.V. |
| title |
The benefits of analysing complete mitochondrial genomes: Deep insights into the phylogeny and population structure of Echinococcus granulosus sensu lato genotypes G6 and G7 |
| title_short |
The benefits of analysing complete mitochondrial genomes: Deep insights into the phylogeny and population structure of Echinococcus granulosus sensu lato genotypes G6 and G7 |
| title_full |
The benefits of analysing complete mitochondrial genomes: Deep insights into the phylogeny and population structure of Echinococcus granulosus sensu lato genotypes G6 and G7 |
| title_fullStr |
The benefits of analysing complete mitochondrial genomes: Deep insights into the phylogeny and population structure of Echinococcus granulosus sensu lato genotypes G6 and G7 |
| title_full_unstemmed |
The benefits of analysing complete mitochondrial genomes: Deep insights into the phylogeny and population structure of Echinococcus granulosus sensu lato genotypes G6 and G7 |
| title_sort |
benefits of analysing complete mitochondrial genomes: deep insights into the phylogeny and population structure of echinococcus granulosus sensu lato genotypes g6 and g7 |
| publishDate |
2018 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15671348_v64_n_p85_Laurimae http://hdl.handle.net/20.500.12110/paper_15671348_v64_n_p85_Laurimae |
| _version_ |
1768545757371039744 |