The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing

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Dengue virus NS5 protein plays multiple functions in the cytoplasm of infected cells, enabling viral RNA replication and counteracting host antiviral responses. Here, we demonstrate a novel function of NS5 in the nucleus where it interferes with cellular splicing. Using global proteomic analysis of...

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Detalles Bibliográficos
Autores principales:	Risso, Guillermo Javier, Pozzi, Maria Berta, Yanovsky, Marcelo Javier, Srebrow, Anabella
Publicado:	2016
Materias:	complementary DNA cystic fibrosis transmembrane conductance regulator monoclonal antibody nonstructural protein 5 polyclonal antibody protein bcl x small nuclear ribonucleoprotein STAT2 protein NS5 protein, dengue virus viral protein A549 cell line alternative RNA splicing Article cell fractionation controlled study dengue Dengue virus gene expression regulation genetic transfection hepatocellular carcinoma cell line high throughput sequencing host pathogen interaction human human cell immunofluorescence test protein localization protein protein interaction protein purification proteomics real time polymerase chain reaction RNA processing RNAi therapeutics spliceosome virus recombinant virus replication Western blotting animal cell line fluorescent antibody technique genetics host parasite interaction metabolism pathogenicity physiology polymerase chain reaction RNA splicing virology Animals Cell Line Dengue Dengue Virus Fluorescent Antibody Technique High-Throughput Nucleotide Sequencing Host-Parasite Interactions Humans Polymerase Chain Reaction Ribonucleoprotein, U5 Small Nuclear RNA Splicing Spliceosomes Transfection Viral Nonstructural Proteins
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15537366_v12_n8_p_DeMaio http://hdl.handle.net/20.500.12110/paper_15537366_v12_n8_p_DeMaio
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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