Protein Topology Determines Cysteine Oxidation Fate: The Case of Sulfenyl Amide Formation among Protein Families

Cysteine residues have a rich chemistry and play a critical role in the catalytic activity of a plethora of enzymes. However, cysteines are susceptible to oxidation by Reactive Oxygen and Nitrogen Species, leading to a loss of their catalytic function. Therefore, cysteine oxidation is emerging as a...

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Detalles Bibliográficos
Publicado: 2015
Materias:
acid
amide
carbon nitrogen hydrolase
cysteine
DJ 1 protein
glutamine amidotransferase
hydrolase
phosphatase
protein tyrosine phosphatase
SNO glutamine amidotransferase
sulfenic acid
sulfenyl amide
thiosulfate sulfurtransferase
transferase
unclassified drug
protein
sulfenic acid derivative
amino acid analysis
Article
catalysis
chemical analysis
chemical structure
conformational transition
controlled study
molecular dynamics
molecular evolution
oxidation reduction reaction
protein folding
protein function
protein localization
reaction time
residue analysis
sequence analysis
biology
chemistry
metabolism
molecular model
protein conformation
Amides
Computational Biology
Cysteine
Models, Molecular
Oxidation-Reduction
Protein Conformation
Proteins
Sulfenic Acids
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1553734X_v11_n3_p_Defelipe
http://hdl.handle.net/20.500.12110/paper_1553734X_v11_n3_p_Defelipe
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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