Topiramate heterocyclic analogues: Synthesis and spectroscopic characterization

Herein we describe the synthesis of a set of heterocyclic analogues of topiramate as possible therapeutic agents for epileptic seizure treatment. The new compounds and their precursors were characterized by physical, as well as spectroscopic techniques. We verified that the preferential conformation...

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Detalles Bibliográficos
Publicado: 2011
Materias:
D-fructose
Heterocyclic rings
Spectroscopic data
Topiramate
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1551-701_v2011_n7_p136_Alho
http://hdl.handle.net/20.500.12110/paper_1551-701_v2011_n7_p136_Alho
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_1551-701_v2011_n7_p136_Alho
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spelling paper:paper_1551-701_v2011_n7_p136_Alho2023-06-08T16:23:01Z Topiramate heterocyclic analogues: Synthesis and spectroscopic characterization D-fructose Heterocyclic rings Spectroscopic data Topiramate Herein we describe the synthesis of a set of heterocyclic analogues of topiramate as possible therapeutic agents for epileptic seizure treatment. The new compounds and their precursors were characterized by physical, as well as spectroscopic techniques. We verified that the preferential conformation in solution of the carbohydrate ring is twist-boat. The stereochemistry of the new asymmetric centre, generated during the heterocyclizations, was proposed using NOESY experiment. These novel compounds could help to elucidate the mechanism of action of the commercial drug used for this disease. © ARKAT-USA, Inc. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1551-701_v2011_n7_p136_Alho http://hdl.handle.net/20.500.12110/paper_1551-701_v2011_n7_p136_Alho
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic D-fructose
Heterocyclic rings
Spectroscopic data
Topiramate
spellingShingle D-fructose
Heterocyclic rings
Spectroscopic data
Topiramate
Topiramate heterocyclic analogues: Synthesis and spectroscopic characterization
topic_facet D-fructose
Heterocyclic rings
Spectroscopic data
Topiramate
description Herein we describe the synthesis of a set of heterocyclic analogues of topiramate as possible therapeutic agents for epileptic seizure treatment. The new compounds and their precursors were characterized by physical, as well as spectroscopic techniques. We verified that the preferential conformation in solution of the carbohydrate ring is twist-boat. The stereochemistry of the new asymmetric centre, generated during the heterocyclizations, was proposed using NOESY experiment. These novel compounds could help to elucidate the mechanism of action of the commercial drug used for this disease. © ARKAT-USA, Inc.
title Topiramate heterocyclic analogues: Synthesis and spectroscopic characterization
title_short Topiramate heterocyclic analogues: Synthesis and spectroscopic characterization
title_full Topiramate heterocyclic analogues: Synthesis and spectroscopic characterization
title_fullStr Topiramate heterocyclic analogues: Synthesis and spectroscopic characterization
title_full_unstemmed Topiramate heterocyclic analogues: Synthesis and spectroscopic characterization
title_sort topiramate heterocyclic analogues: synthesis and spectroscopic characterization
publishDate 2011
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1551-701_v2011_n7_p136_Alho
http://hdl.handle.net/20.500.12110/paper_1551-701_v2011_n7_p136_Alho
_version_ 1768545067754061824

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