Coupling between nucleotide excision repair and gene expression

Gene expression and DNA repair are fundamental processes for life. During the last decade, accumulating experimental evidence point towards different modes of coupling between these processes. Here we discuss the molecular mechanisms by which RNAPII-dependent transcription affects repair by the Nucl...

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Publicado:	2018
Materias:	Gene expression Nucleotide Excision Repair UV light Xeroderma Pigmentosum single stranded DNA ATM protein ATR protein, human DNA helicase RNA polymerase II Article clinical feature DNA damage response DNA repair DNA replication excision repair gene expression human interactions with DNA phenotype xeroderma pigmentosum Cockayne syndrome DNA damage enzymology genetic transcription genetics metabolism mutation physiology radiation response skin ultraviolet radiation Ataxia Telangiectasia Mutated Proteins Cockayne Syndrome DNA Damage DNA Helicases DNA Repair DNA, Single-Stranded Gene Expression Humans Mutation RNA Polymerase II Skin Transcription, Genetic Ultraviolet Rays
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15476286_v15_n7_p845_AdrianE http://hdl.handle.net/20.500.12110/paper_15476286_v15_n7_p845_AdrianE
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_15476286_v15_n7_p845_AdrianE
record_format	dspace
spelling	paper:paper_15476286_v15_n7_p845_AdrianE2023-06-08T16:21:20Z Coupling between nucleotide excision repair and gene expression Gene expression Nucleotide Excision Repair UV light Xeroderma Pigmentosum single stranded DNA ATM protein ATR protein, human DNA helicase RNA polymerase II single stranded DNA Article clinical feature DNA damage response DNA repair DNA replication excision repair gene expression human interactions with DNA phenotype xeroderma pigmentosum Cockayne syndrome DNA damage enzymology gene expression genetic transcription genetics metabolism mutation physiology radiation response skin ultraviolet radiation Ataxia Telangiectasia Mutated Proteins Cockayne Syndrome DNA Damage DNA Helicases DNA Repair DNA, Single-Stranded Gene Expression Humans Mutation RNA Polymerase II Skin Transcription, Genetic Ultraviolet Rays Xeroderma Pigmentosum Gene expression and DNA repair are fundamental processes for life. During the last decade, accumulating experimental evidence point towards different modes of coupling between these processes. Here we discuss the molecular mechanisms by which RNAPII-dependent transcription affects repair by the Nucleotide Excision Repair system (NER) and how NER activity, through the generation of single stranded DNA intermediates and activation of the DNA damage response kinase ATR, drives gene expression in a genotoxic scenario. Since NER-dependent repair is compromised in Xeroderma Pigmentosum (XP) patients, and having in mind that these patients present a high degree of clinical heterogeneity, we speculate that some of the clinical features of XP patients can be explained by misregulation of gene expression. © 2018, © 2018 Taylor & Francis Group, LLC. 2018 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15476286_v15_n7_p845_AdrianE http://hdl.handle.net/20.500.12110/paper_15476286_v15_n7_p845_AdrianE
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Gene expression Nucleotide Excision Repair UV light Xeroderma Pigmentosum single stranded DNA ATM protein ATR protein, human DNA helicase RNA polymerase II single stranded DNA Article clinical feature DNA damage response DNA repair DNA replication excision repair gene expression human interactions with DNA phenotype xeroderma pigmentosum Cockayne syndrome DNA damage enzymology gene expression genetic transcription genetics metabolism mutation physiology radiation response skin ultraviolet radiation Ataxia Telangiectasia Mutated Proteins Cockayne Syndrome DNA Damage DNA Helicases DNA Repair DNA, Single-Stranded Gene Expression Humans Mutation RNA Polymerase II Skin Transcription, Genetic Ultraviolet Rays Xeroderma Pigmentosum
spellingShingle	Gene expression Nucleotide Excision Repair UV light Xeroderma Pigmentosum single stranded DNA ATM protein ATR protein, human DNA helicase RNA polymerase II single stranded DNA Article clinical feature DNA damage response DNA repair DNA replication excision repair gene expression human interactions with DNA phenotype xeroderma pigmentosum Cockayne syndrome DNA damage enzymology gene expression genetic transcription genetics metabolism mutation physiology radiation response skin ultraviolet radiation Ataxia Telangiectasia Mutated Proteins Cockayne Syndrome DNA Damage DNA Helicases DNA Repair DNA, Single-Stranded Gene Expression Humans Mutation RNA Polymerase II Skin Transcription, Genetic Ultraviolet Rays Xeroderma Pigmentosum Coupling between nucleotide excision repair and gene expression
topic_facet	Gene expression Nucleotide Excision Repair UV light Xeroderma Pigmentosum single stranded DNA ATM protein ATR protein, human DNA helicase RNA polymerase II single stranded DNA Article clinical feature DNA damage response DNA repair DNA replication excision repair gene expression human interactions with DNA phenotype xeroderma pigmentosum Cockayne syndrome DNA damage enzymology gene expression genetic transcription genetics metabolism mutation physiology radiation response skin ultraviolet radiation Ataxia Telangiectasia Mutated Proteins Cockayne Syndrome DNA Damage DNA Helicases DNA Repair DNA, Single-Stranded Gene Expression Humans Mutation RNA Polymerase II Skin Transcription, Genetic Ultraviolet Rays Xeroderma Pigmentosum
description	Gene expression and DNA repair are fundamental processes for life. During the last decade, accumulating experimental evidence point towards different modes of coupling between these processes. Here we discuss the molecular mechanisms by which RNAPII-dependent transcription affects repair by the Nucleotide Excision Repair system (NER) and how NER activity, through the generation of single stranded DNA intermediates and activation of the DNA damage response kinase ATR, drives gene expression in a genotoxic scenario. Since NER-dependent repair is compromised in Xeroderma Pigmentosum (XP) patients, and having in mind that these patients present a high degree of clinical heterogeneity, we speculate that some of the clinical features of XP patients can be explained by misregulation of gene expression. © 2018, © 2018 Taylor & Francis Group, LLC.
title	Coupling between nucleotide excision repair and gene expression
title_short	Coupling between nucleotide excision repair and gene expression
title_full	Coupling between nucleotide excision repair and gene expression
title_fullStr	Coupling between nucleotide excision repair and gene expression
title_full_unstemmed	Coupling between nucleotide excision repair and gene expression
title_sort	coupling between nucleotide excision repair and gene expression
publishDate	2018
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15476286_v15_n7_p845_AdrianE http://hdl.handle.net/20.500.12110/paper_15476286_v15_n7_p845_AdrianE
_version_	1768546740219150336

Coupling between nucleotide excision repair and gene expression

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