When chromatin meets splicing

Using bioinformatics analysis of previously published global genome deep-sequencing data, two papers now show that DNA sequences associated with nucleosomes are preferentially located in exons. The correlation between nucleosome distribution and the exon-intron organization of genes may have a key r...

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Detalles Bibliográficos
Autores principales: Kornblihtt, Alberto Rodolfo, Schor, Ignacio Esteban, Allo, Mariano
Publicado: 2009
Materias:
alternative RNA splicing
bioinformatics
chromatin
DNA sequence
exon
genome
genome analysis
human
intron
molecular recognition
nonhuman
nucleosome
priority journal
regulatory mechanism
short survey
Alternative Splicing
Animals
Base Composition
Chromatin
Exons
Humans
Introns
RNA Precursors
Transcription, Genetic
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15459993_v16_n9_p902_Kornblihtt
http://hdl.handle.net/20.500.12110/paper_15459993_v16_n9_p902_Kornblihtt
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Using bioinformatics analysis of previously published global genome deep-sequencing data, two papers now show that DNA sequences associated with nucleosomes are preferentially located in exons. The correlation between nucleosome distribution and the exon-intron organization of genes may have a key role in exon recognition at the pre-mRNA level during co-transcriptional splicing, consistent with previous findings indicating chromatin-mediated regulation of alternative splicing. © 2009 Nature America, Inc. All rights reserved.

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