When chromatin meets splicing

Using bioinformatics analysis of previously published global genome deep-sequencing data, two papers now show that DNA sequences associated with nucleosomes are preferentially located in exons. The correlation between nucleosome distribution and the exon-intron organization of genes may have a key r...

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Detalles Bibliográficos
Autores principales:	Kornblihtt, Alberto Rodolfo, Schor, Ignacio Esteban, Allo, Mariano
Publicado:	2009
Materias:	alternative RNA splicing bioinformatics chromatin DNA sequence exon genome genome analysis human intron molecular recognition nonhuman nucleosome priority journal regulatory mechanism short survey Alternative Splicing Animals Base Composition Chromatin Exons Humans Introns RNA Precursors Transcription, Genetic
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15459993_v16_n9_p902_Kornblihtt http://hdl.handle.net/20.500.12110/paper_15459993_v16_n9_p902_Kornblihtt
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_15459993_v16_n9_p902_Kornblihtt
record_format	dspace
spelling	paper:paper_15459993_v16_n9_p902_Kornblihtt2023-06-08T16:21:15Z When chromatin meets splicing Kornblihtt, Alberto Rodolfo Schor, Ignacio Esteban Allo, Mariano alternative RNA splicing bioinformatics chromatin DNA sequence exon genome genome analysis human intron molecular recognition nonhuman nucleosome priority journal regulatory mechanism short survey Alternative Splicing Animals Base Composition Chromatin Exons Humans Introns RNA Precursors Transcription, Genetic Using bioinformatics analysis of previously published global genome deep-sequencing data, two papers now show that DNA sequences associated with nucleosomes are preferentially located in exons. The correlation between nucleosome distribution and the exon-intron organization of genes may have a key role in exon recognition at the pre-mRNA level during co-transcriptional splicing, consistent with previous findings indicating chromatin-mediated regulation of alternative splicing. © 2009 Nature America, Inc. All rights reserved. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Schor, I.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Allo, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15459993_v16_n9_p902_Kornblihtt http://hdl.handle.net/20.500.12110/paper_15459993_v16_n9_p902_Kornblihtt
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	alternative RNA splicing bioinformatics chromatin DNA sequence exon genome genome analysis human intron molecular recognition nonhuman nucleosome priority journal regulatory mechanism short survey Alternative Splicing Animals Base Composition Chromatin Exons Humans Introns RNA Precursors Transcription, Genetic
spellingShingle	alternative RNA splicing bioinformatics chromatin DNA sequence exon genome genome analysis human intron molecular recognition nonhuman nucleosome priority journal regulatory mechanism short survey Alternative Splicing Animals Base Composition Chromatin Exons Humans Introns RNA Precursors Transcription, Genetic Kornblihtt, Alberto Rodolfo Schor, Ignacio Esteban Allo, Mariano When chromatin meets splicing
topic_facet	alternative RNA splicing bioinformatics chromatin DNA sequence exon genome genome analysis human intron molecular recognition nonhuman nucleosome priority journal regulatory mechanism short survey Alternative Splicing Animals Base Composition Chromatin Exons Humans Introns RNA Precursors Transcription, Genetic
description	Using bioinformatics analysis of previously published global genome deep-sequencing data, two papers now show that DNA sequences associated with nucleosomes are preferentially located in exons. The correlation between nucleosome distribution and the exon-intron organization of genes may have a key role in exon recognition at the pre-mRNA level during co-transcriptional splicing, consistent with previous findings indicating chromatin-mediated regulation of alternative splicing. © 2009 Nature America, Inc. All rights reserved.
author	Kornblihtt, Alberto Rodolfo Schor, Ignacio Esteban Allo, Mariano
author_facet	Kornblihtt, Alberto Rodolfo Schor, Ignacio Esteban Allo, Mariano
author_sort	Kornblihtt, Alberto Rodolfo
title	When chromatin meets splicing
title_short	When chromatin meets splicing
title_full	When chromatin meets splicing
title_fullStr	When chromatin meets splicing
title_full_unstemmed	When chromatin meets splicing
title_sort	when chromatin meets splicing
publishDate	2009
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15459993_v16_n9_p902_Kornblihtt http://hdl.handle.net/20.500.12110/paper_15459993_v16_n9_p902_Kornblihtt
work_keys_str_mv	AT kornblihttalbertorodolfo whenchromatinmeetssplicing AT schorignacioesteban whenchromatinmeetssplicing AT allomariano whenchromatinmeetssplicing
_version_	1768542805676785664

When chromatin meets splicing

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