Protective action of antioxidants on hepatic damage induced by griseofulvin

Erythropoietic protoporphyria (EPP) is a disease associated with ferrochelatase deficiency and characterized by the accumulation of protoporphyrin IX (PROTO IX) in erythrocytes, liver, and skin. In some cases, a severe hepatic failure and cholestasis were observed. Griseofulvin (Gris) develops an ex...

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Autores principales:	Martínez, María del Carmen, Afonso, Susana Graciela, Buzaleh, Ana María, Batlle, Alcira María del Carmen
Publicado:	2014
Materias:	antifungal agent antioxidant biological marker glutathione griseofulvin heme superoxide dismutase animal article disease model male metabolism mouse toxic hepatitis Animals Antifungal Agents Antioxidants Biological Markers Disease Models, Animal Drug-Induced Liver Injury Glutathione Griseofulvin Heme Male Mice Superoxide Dismutase
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1537744X_v2014_n_p_Martinez http://hdl.handle.net/20.500.12110/paper_1537744X_v2014_n_p_Martinez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_1537744X_v2014_n_p_Martinez
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spelling	paper:paper_1537744X_v2014_n_p_Martinez2023-06-08T16:20:16Z Protective action of antioxidants on hepatic damage induced by griseofulvin Martínez, María del Carmen Afonso, Susana Graciela Buzaleh, Ana María Batlle, Alcira María del Carmen antifungal agent antioxidant biological marker glutathione griseofulvin heme superoxide dismutase animal article disease model male metabolism mouse toxic hepatitis Animals Antifungal Agents Antioxidants Biological Markers Disease Models, Animal Drug-Induced Liver Injury Glutathione Griseofulvin Heme Male Mice Superoxide Dismutase Erythropoietic protoporphyria (EPP) is a disease associated with ferrochelatase deficiency and characterized by the accumulation of protoporphyrin IX (PROTO IX) in erythrocytes, liver, and skin. In some cases, a severe hepatic failure and cholestasis were observed. Griseofulvin (Gris) develops an experimental EPP with hepatic manifestations in mice such as PROTO IX accumulation followed by cellular damage as wells as necrotic and inflammatory processes. The antioxidant defense system was also altered. The aim was to evaluate the possible protective effect of different antioxidant compounds: trolox (Tx), ascorbic acid (Asc), the combination Tx and Asc, melatonin (Mel), and the polyphenols: ellagic acid, quercetin, chlorogenic acid, caffeic acid, gallic acid, and ferulic acid on liver damage and oxidative stress markers in a mouse model of EPP. Coadministration of Gris with Tx, Asc, and its combination, or Mel mainly affected heme biosynthetic pathway, resulting in a decrease in ALA-S activity which was increased by Gris, while the tested polyphenols exerted a protective effect on oxidative stress, decreasing lipid peroxidation and the activity of some antioxidant enzymes. In conclusion, antioxidant compounds can only protect partially against the liver damage induced by Gris, reducing oxidative stress or acting on heme regulation. © 2014 M. del C. Martinez et al. Fil:Martinez, M.D.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Afonso, S.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Batlle, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1537744X_v2014_n_p_Martinez http://hdl.handle.net/20.500.12110/paper_1537744X_v2014_n_p_Martinez
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	antifungal agent antioxidant biological marker glutathione griseofulvin heme superoxide dismutase animal article disease model male metabolism mouse toxic hepatitis Animals Antifungal Agents Antioxidants Biological Markers Disease Models, Animal Drug-Induced Liver Injury Glutathione Griseofulvin Heme Male Mice Superoxide Dismutase
spellingShingle	antifungal agent antioxidant biological marker glutathione griseofulvin heme superoxide dismutase animal article disease model male metabolism mouse toxic hepatitis Animals Antifungal Agents Antioxidants Biological Markers Disease Models, Animal Drug-Induced Liver Injury Glutathione Griseofulvin Heme Male Mice Superoxide Dismutase Martínez, María del Carmen Afonso, Susana Graciela Buzaleh, Ana María Batlle, Alcira María del Carmen Protective action of antioxidants on hepatic damage induced by griseofulvin
topic_facet	antifungal agent antioxidant biological marker glutathione griseofulvin heme superoxide dismutase animal article disease model male metabolism mouse toxic hepatitis Animals Antifungal Agents Antioxidants Biological Markers Disease Models, Animal Drug-Induced Liver Injury Glutathione Griseofulvin Heme Male Mice Superoxide Dismutase
description	Erythropoietic protoporphyria (EPP) is a disease associated with ferrochelatase deficiency and characterized by the accumulation of protoporphyrin IX (PROTO IX) in erythrocytes, liver, and skin. In some cases, a severe hepatic failure and cholestasis were observed. Griseofulvin (Gris) develops an experimental EPP with hepatic manifestations in mice such as PROTO IX accumulation followed by cellular damage as wells as necrotic and inflammatory processes. The antioxidant defense system was also altered. The aim was to evaluate the possible protective effect of different antioxidant compounds: trolox (Tx), ascorbic acid (Asc), the combination Tx and Asc, melatonin (Mel), and the polyphenols: ellagic acid, quercetin, chlorogenic acid, caffeic acid, gallic acid, and ferulic acid on liver damage and oxidative stress markers in a mouse model of EPP. Coadministration of Gris with Tx, Asc, and its combination, or Mel mainly affected heme biosynthetic pathway, resulting in a decrease in ALA-S activity which was increased by Gris, while the tested polyphenols exerted a protective effect on oxidative stress, decreasing lipid peroxidation and the activity of some antioxidant enzymes. In conclusion, antioxidant compounds can only protect partially against the liver damage induced by Gris, reducing oxidative stress or acting on heme regulation. © 2014 M. del C. Martinez et al.
author	Martínez, María del Carmen Afonso, Susana Graciela Buzaleh, Ana María Batlle, Alcira María del Carmen
author_facet	Martínez, María del Carmen Afonso, Susana Graciela Buzaleh, Ana María Batlle, Alcira María del Carmen
author_sort	Martínez, María del Carmen
title	Protective action of antioxidants on hepatic damage induced by griseofulvin
title_short	Protective action of antioxidants on hepatic damage induced by griseofulvin
title_full	Protective action of antioxidants on hepatic damage induced by griseofulvin
title_fullStr	Protective action of antioxidants on hepatic damage induced by griseofulvin
title_full_unstemmed	Protective action of antioxidants on hepatic damage induced by griseofulvin
title_sort	protective action of antioxidants on hepatic damage induced by griseofulvin
publishDate	2014
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1537744X_v2014_n_p_Martinez http://hdl.handle.net/20.500.12110/paper_1537744X_v2014_n_p_Martinez
work_keys_str_mv	AT martinezmariadelcarmen protectiveactionofantioxidantsonhepaticdamageinducedbygriseofulvin AT afonsosusanagraciela protectiveactionofantioxidantsonhepaticdamageinducedbygriseofulvin AT buzalehanamaria protectiveactionofantioxidantsonhepaticdamageinducedbygriseofulvin AT batllealciramariadelcarmen protectiveactionofantioxidantsonhepaticdamageinducedbygriseofulvin
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Protective action of antioxidants on hepatic damage induced by griseofulvin

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