Glycans Pave the Way for Immunotherapy in Triple-Negative Breast Cancer
The clinical efficacy of therapies targeting the PD-1/PD-L1 pathway is still limited. In this issue of Cancer Cell, Li and colleagues identify a PD-L1 glycosylation-based mechanism in triple-negative breast cancer that fosters immunosuppression by enhancing interactions with PD-1. Targeting glycosyl...
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Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15356108_v33_n2_p155_Salatino http://hdl.handle.net/20.500.12110/paper_15356108_v33_n2_p155_Salatino |
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paper:paper_15356108_v33_n2_p155_Salatino2023-06-08T16:20:06Z Glycans Pave the Way for Immunotherapy in Triple-Negative Breast Cancer asparagine linked oligosaccharide epidermal growth factor glycan glycogen synthase kinase transcription factor 4 polysaccharide programmed death 1 ligand 1 cancer immunotherapy cytotoxicity ectopic expression endocytosis glycosylation human immunosuppressive treatment lysosome nonhuman priority journal protein protein interaction Short Survey treatment response triple negative breast cancer tumor microenvironment tumor rejection upregulation immunotherapy B7-H1 Antigen Humans Immunotherapy Polysaccharides Triple Negative Breast Neoplasms The clinical efficacy of therapies targeting the PD-1/PD-L1 pathway is still limited. In this issue of Cancer Cell, Li and colleagues identify a PD-L1 glycosylation-based mechanism in triple-negative breast cancer that fosters immunosuppression by enhancing interactions with PD-1. Targeting glycosylated PD-L1 with a drug-conjugated antibody opens new avenues for treatment. The clinical efficacy of therapies targeting the PD-1/PD-L1 pathway is still limited. In this issue of Cancer Cell, Li and colleagues identify a PD-L1 glycosylation-based mechanism in triple-negative breast cancer that fosters immunosuppression by enhancing interactions with PD-1. Targeting glycosylated PD-L1 with a drug-conjugated antibody opens new avenues for treatment. © 2018 Elsevier Inc. 2018 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15356108_v33_n2_p155_Salatino http://hdl.handle.net/20.500.12110/paper_15356108_v33_n2_p155_Salatino |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
asparagine linked oligosaccharide epidermal growth factor glycan glycogen synthase kinase transcription factor 4 polysaccharide programmed death 1 ligand 1 cancer immunotherapy cytotoxicity ectopic expression endocytosis glycosylation human immunosuppressive treatment lysosome nonhuman priority journal protein protein interaction Short Survey treatment response triple negative breast cancer tumor microenvironment tumor rejection upregulation immunotherapy B7-H1 Antigen Humans Immunotherapy Polysaccharides Triple Negative Breast Neoplasms |
spellingShingle |
asparagine linked oligosaccharide epidermal growth factor glycan glycogen synthase kinase transcription factor 4 polysaccharide programmed death 1 ligand 1 cancer immunotherapy cytotoxicity ectopic expression endocytosis glycosylation human immunosuppressive treatment lysosome nonhuman priority journal protein protein interaction Short Survey treatment response triple negative breast cancer tumor microenvironment tumor rejection upregulation immunotherapy B7-H1 Antigen Humans Immunotherapy Polysaccharides Triple Negative Breast Neoplasms Glycans Pave the Way for Immunotherapy in Triple-Negative Breast Cancer |
topic_facet |
asparagine linked oligosaccharide epidermal growth factor glycan glycogen synthase kinase transcription factor 4 polysaccharide programmed death 1 ligand 1 cancer immunotherapy cytotoxicity ectopic expression endocytosis glycosylation human immunosuppressive treatment lysosome nonhuman priority journal protein protein interaction Short Survey treatment response triple negative breast cancer tumor microenvironment tumor rejection upregulation immunotherapy B7-H1 Antigen Humans Immunotherapy Polysaccharides Triple Negative Breast Neoplasms |
description |
The clinical efficacy of therapies targeting the PD-1/PD-L1 pathway is still limited. In this issue of Cancer Cell, Li and colleagues identify a PD-L1 glycosylation-based mechanism in triple-negative breast cancer that fosters immunosuppression by enhancing interactions with PD-1. Targeting glycosylated PD-L1 with a drug-conjugated antibody opens new avenues for treatment. The clinical efficacy of therapies targeting the PD-1/PD-L1 pathway is still limited. In this issue of Cancer Cell, Li and colleagues identify a PD-L1 glycosylation-based mechanism in triple-negative breast cancer that fosters immunosuppression by enhancing interactions with PD-1. Targeting glycosylated PD-L1 with a drug-conjugated antibody opens new avenues for treatment. © 2018 Elsevier Inc. |
title |
Glycans Pave the Way for Immunotherapy in Triple-Negative Breast Cancer |
title_short |
Glycans Pave the Way for Immunotherapy in Triple-Negative Breast Cancer |
title_full |
Glycans Pave the Way for Immunotherapy in Triple-Negative Breast Cancer |
title_fullStr |
Glycans Pave the Way for Immunotherapy in Triple-Negative Breast Cancer |
title_full_unstemmed |
Glycans Pave the Way for Immunotherapy in Triple-Negative Breast Cancer |
title_sort |
glycans pave the way for immunotherapy in triple-negative breast cancer |
publishDate |
2018 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15356108_v33_n2_p155_Salatino http://hdl.handle.net/20.500.12110/paper_15356108_v33_n2_p155_Salatino |
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1768544656434397184 |