Micro/nanostructured hyaluronic acid matrices with tuned swelling and drug release properties

Hyaluronic acid (HA) hydrogels were structured in the form of porous monoliths by means of the ice-segregation-induced self-assembly (ISISA) method coupled with freeze-drying. Physical and chemical parameters were explored in order to fine-tune the microstructure and the incidence on both swelling a...

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Detalles Bibliográficos
Autores principales: Minaberry, Yanina Susana, Jobbagy, Matias
Publicado: 2013
Materias:
Aqueous media
Dissolution behavior
Drug release properties
Hyaluronic acids
Physical and chemical parameters
Porous monoliths
Scanning electron microscopy
Thermoanalysis
Organic acids
gentamicin
hyaluronic acid
article
chemical structure
drug release
extracellular matrix
freeze drying
hydrogel
physical parameters
priority journal
scanning electron microscopy
thermal analysis
tuned swelling
Drug Carriers
Gentamicins
Hyaluronic Acid
Hydrogels
Microspheres
Nanostructures
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15257797_v14_n1_p1_Minaberry
http://hdl.handle.net/20.500.12110/paper_15257797_v14_n1_p1_Minaberry
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Hyaluronic acid (HA) hydrogels were structured in the form of porous monoliths by means of the ice-segregation-induced self-assembly (ISISA) method coupled with freeze-drying. Physical and chemical parameters were explored in order to fine-tune the microstructure and the incidence on both swelling and dissolution behavior in aqueous media. Gentamicin-loaded HA matrices with tuned drug release properties were also prepared; their inherent properties and behavior in solution are discussed in the framework of thermal analysis and scanning electron microscopy inspection. © 2012 American Chemical Society.

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