Antioxidant mechanisms of the nereidid Laeonereis acuta (Anelida: Polychaeta) to cope with environmental hydrogen peroxide

Hydrogen peroxide (H2O2) is a naturally occurring prooxidant molecule, and its effects in the macroinvertebrate infauna were previously observed. The existence of a gradient of antioxidant enzymes activity (catalase [CAT], glutathione peroxidase [GPx], superoxide dismutase [SOD], and glutathione-S-t...

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Autores principales:	Iurman, Mariana Gabriela, Monserrat, José María
Publicado:	2005
Materias:	catalase glutathione peroxidase glutathione transferase hydrogen peroxide superoxide dismutase antioxidant adaptation analysis of variance animal article comet assay comparative study DNA damage enzymology metabolism mucus oxidative stress physiology Polychaeta time Adaptation, Physiological Analysis of Variance Animals Catalase Comet Assay DNA Damage Glutathione Peroxidase Glutathione Transferase Hydrogen Peroxide Mucus Oxidative Stress Superoxide Dismutase Time Factors Animalia Laeonereis acuta Nereididae
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15222152_v78_n4_p641_DaRosa http://hdl.handle.net/20.500.12110/paper_15222152_v78_n4_p641_DaRosa
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_15222152_v78_n4_p641_DaRosa
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spelling	paper:paper_15222152_v78_n4_p641_DaRosa2023-06-08T16:19:22Z Antioxidant mechanisms of the nereidid Laeonereis acuta (Anelida: Polychaeta) to cope with environmental hydrogen peroxide Iurman, Mariana Gabriela Monserrat, José María catalase glutathione peroxidase glutathione transferase hydrogen peroxide superoxide dismutase antioxidant adaptation analysis of variance animal article comet assay comparative study DNA damage enzymology metabolism mucus oxidative stress physiology Polychaeta time Adaptation, Physiological Analysis of Variance Animals Catalase Comet Assay DNA Damage Glutathione Peroxidase Glutathione Transferase Hydrogen Peroxide Mucus Oxidative Stress Polychaeta Superoxide Dismutase Time Factors Animalia Laeonereis acuta Nereididae Polychaeta Hydrogen peroxide (H2O2) is a naturally occurring prooxidant molecule, and its effects in the macroinvertebrate infauna were previously observed. The existence of a gradient of antioxidant enzymes activity (catalase [CAT], glutathione peroxidase [GPx], superoxide dismutase [SOD], and glutathione-S-transferase [GST]) and/or oxidative damage along the body of the estuarine polychaeta Laeonereis acuta (Polychaeta, Nereididae) was analyzed after exposure to H2O2. Because this species secretes conspicuous amounts of mucus, its capability in degrading H2O 2 was studied. The results suggest that L. acuta deal with the generation of oxidative stress with different strategies along the body. In the posterior region, higher CAT and SOD activities ensure the degradation of inductors of lipid peroxidation such as H2O2 and superoxide anion (O2•-). The higher GST activity in anterior region aids to conjugate lipid peroxides products. In the middle region, the lack of high CAT, SOD, or GST activities correlates with the higher lipid hydroperoxide levels found after H2O2 exposure. Ten days of exposure to H2O2 also induced oxidative stress (lipid peroxidation and DNA damage) in the whole animal paralleled by a lack of CAT induction. The mucus production contributes substantially to H 2O2 degradation, suggesting that bacteria that grow in this secretion provide this capability. © 2005 by The University of Chicago. All rights reserved. Fil:Iurman, M.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Monserrat, J.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2005 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15222152_v78_n4_p641_DaRosa http://hdl.handle.net/20.500.12110/paper_15222152_v78_n4_p641_DaRosa
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	catalase glutathione peroxidase glutathione transferase hydrogen peroxide superoxide dismutase antioxidant adaptation analysis of variance animal article comet assay comparative study DNA damage enzymology metabolism mucus oxidative stress physiology Polychaeta time Adaptation, Physiological Analysis of Variance Animals Catalase Comet Assay DNA Damage Glutathione Peroxidase Glutathione Transferase Hydrogen Peroxide Mucus Oxidative Stress Polychaeta Superoxide Dismutase Time Factors Animalia Laeonereis acuta Nereididae Polychaeta
spellingShingle	catalase glutathione peroxidase glutathione transferase hydrogen peroxide superoxide dismutase antioxidant adaptation analysis of variance animal article comet assay comparative study DNA damage enzymology metabolism mucus oxidative stress physiology Polychaeta time Adaptation, Physiological Analysis of Variance Animals Catalase Comet Assay DNA Damage Glutathione Peroxidase Glutathione Transferase Hydrogen Peroxide Mucus Oxidative Stress Polychaeta Superoxide Dismutase Time Factors Animalia Laeonereis acuta Nereididae Polychaeta Iurman, Mariana Gabriela Monserrat, José María Antioxidant mechanisms of the nereidid Laeonereis acuta (Anelida: Polychaeta) to cope with environmental hydrogen peroxide
topic_facet	catalase glutathione peroxidase glutathione transferase hydrogen peroxide superoxide dismutase antioxidant adaptation analysis of variance animal article comet assay comparative study DNA damage enzymology metabolism mucus oxidative stress physiology Polychaeta time Adaptation, Physiological Analysis of Variance Animals Catalase Comet Assay DNA Damage Glutathione Peroxidase Glutathione Transferase Hydrogen Peroxide Mucus Oxidative Stress Polychaeta Superoxide Dismutase Time Factors Animalia Laeonereis acuta Nereididae Polychaeta
description	Hydrogen peroxide (H2O2) is a naturally occurring prooxidant molecule, and its effects in the macroinvertebrate infauna were previously observed. The existence of a gradient of antioxidant enzymes activity (catalase [CAT], glutathione peroxidase [GPx], superoxide dismutase [SOD], and glutathione-S-transferase [GST]) and/or oxidative damage along the body of the estuarine polychaeta Laeonereis acuta (Polychaeta, Nereididae) was analyzed after exposure to H2O2. Because this species secretes conspicuous amounts of mucus, its capability in degrading H2O 2 was studied. The results suggest that L. acuta deal with the generation of oxidative stress with different strategies along the body. In the posterior region, higher CAT and SOD activities ensure the degradation of inductors of lipid peroxidation such as H2O2 and superoxide anion (O2•-). The higher GST activity in anterior region aids to conjugate lipid peroxides products. In the middle region, the lack of high CAT, SOD, or GST activities correlates with the higher lipid hydroperoxide levels found after H2O2 exposure. Ten days of exposure to H2O2 also induced oxidative stress (lipid peroxidation and DNA damage) in the whole animal paralleled by a lack of CAT induction. The mucus production contributes substantially to H 2O2 degradation, suggesting that bacteria that grow in this secretion provide this capability. © 2005 by The University of Chicago. All rights reserved.
author	Iurman, Mariana Gabriela Monserrat, José María
author_facet	Iurman, Mariana Gabriela Monserrat, José María
author_sort	Iurman, Mariana Gabriela
title	Antioxidant mechanisms of the nereidid Laeonereis acuta (Anelida: Polychaeta) to cope with environmental hydrogen peroxide
title_short	Antioxidant mechanisms of the nereidid Laeonereis acuta (Anelida: Polychaeta) to cope with environmental hydrogen peroxide
title_full	Antioxidant mechanisms of the nereidid Laeonereis acuta (Anelida: Polychaeta) to cope with environmental hydrogen peroxide
title_fullStr	Antioxidant mechanisms of the nereidid Laeonereis acuta (Anelida: Polychaeta) to cope with environmental hydrogen peroxide
title_full_unstemmed	Antioxidant mechanisms of the nereidid Laeonereis acuta (Anelida: Polychaeta) to cope with environmental hydrogen peroxide
title_sort	antioxidant mechanisms of the nereidid laeonereis acuta (anelida: polychaeta) to cope with environmental hydrogen peroxide
publishDate	2005
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15222152_v78_n4_p641_DaRosa http://hdl.handle.net/20.500.12110/paper_15222152_v78_n4_p641_DaRosa
work_keys_str_mv	AT iurmanmarianagabriela antioxidantmechanismsofthenereididlaeonereisacutaanelidapolychaetatocopewithenvironmentalhydrogenperoxide AT monserratjosemaria antioxidantmechanismsofthenereididlaeonereisacutaanelidapolychaetatocopewithenvironmentalhydrogenperoxide
_version_	1768542380952125440

Antioxidant mechanisms of the nereidid Laeonereis acuta (Anelida: Polychaeta) to cope with environmental hydrogen peroxide

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