Alterations in nitric oxide synthase activity and expression in submandibular glands of nod mice
The non-obese diabetic (NOD) mouse model of autoimmune sialadenitis offers the possibility of studying the L-arginine/nitric oxide signaling pathway in salivary glands in basal and neurotransmitter-stimulated conditions and, thus, of analyzing the neural control of the secretory process in the targe...
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2001
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15216616_v101_n1_p86_Rosignoli http://hdl.handle.net/20.500.12110/paper_15216616_v101_n1_p86_Rosignoli |
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paper:paper_15216616_v101_n1_p86_Rosignoli2023-06-08T16:19:19Z Alterations in nitric oxide synthase activity and expression in submandibular glands of nod mice Rosignoli, Florencia Pérez Leirós, Claudia Autoimmune sialadenitis Nitric oxide synthase NOD NOS isoforms Salivary glands VIP autoantibody nitric oxide synthase animal experiment animal model article autoimmunity controlled study enzyme activity flow rate inflammatory cell lymphocyte proliferation mouse neurotransmitter release nonhuman priority journal salivation sialoadenitis Sjoegren syndrome submandibular gland target cell translation regulation The non-obese diabetic (NOD) mouse model of autoimmune sialadenitis offers the possibility of studying the L-arginine/nitric oxide signaling pathway in salivary glands in basal and neurotransmitter-stimulated conditions and, thus, of analyzing the neural control of the secretory process in the target organ. The purpose of this study was to explore putative alterations in the activity and expression of nitric oxide synthase (NOS) in submandibular glands of NOD mice in relation to parotid glands and unrelated tissues. Here we report that NOD mice with incipient signs of secretory dysfunction presented a marked decrease in basal and vasoactive intestinal peptide (VIP)-stimulated NOS activity and a differential expression of NOS I in submandibular glands compared to control BALB/c mice. Similar alterations in NOS I were found in parotid glands but not in brain or spleen of NOD mice. No differences between NOD and controls appeared in NOS II and NOS III expression in any of the tissues studied. © 2001 Academic Press. Fil:Rosignoli, F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pérez Leirós, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2001 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15216616_v101_n1_p86_Rosignoli http://hdl.handle.net/20.500.12110/paper_15216616_v101_n1_p86_Rosignoli |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Autoimmune sialadenitis Nitric oxide synthase NOD NOS isoforms Salivary glands VIP autoantibody nitric oxide synthase animal experiment animal model article autoimmunity controlled study enzyme activity flow rate inflammatory cell lymphocyte proliferation mouse neurotransmitter release nonhuman priority journal salivation sialoadenitis Sjoegren syndrome submandibular gland target cell translation regulation |
| spellingShingle |
Autoimmune sialadenitis Nitric oxide synthase NOD NOS isoforms Salivary glands VIP autoantibody nitric oxide synthase animal experiment animal model article autoimmunity controlled study enzyme activity flow rate inflammatory cell lymphocyte proliferation mouse neurotransmitter release nonhuman priority journal salivation sialoadenitis Sjoegren syndrome submandibular gland target cell translation regulation Rosignoli, Florencia Pérez Leirós, Claudia Alterations in nitric oxide synthase activity and expression in submandibular glands of nod mice |
| topic_facet |
Autoimmune sialadenitis Nitric oxide synthase NOD NOS isoforms Salivary glands VIP autoantibody nitric oxide synthase animal experiment animal model article autoimmunity controlled study enzyme activity flow rate inflammatory cell lymphocyte proliferation mouse neurotransmitter release nonhuman priority journal salivation sialoadenitis Sjoegren syndrome submandibular gland target cell translation regulation |
| description |
The non-obese diabetic (NOD) mouse model of autoimmune sialadenitis offers the possibility of studying the L-arginine/nitric oxide signaling pathway in salivary glands in basal and neurotransmitter-stimulated conditions and, thus, of analyzing the neural control of the secretory process in the target organ. The purpose of this study was to explore putative alterations in the activity and expression of nitric oxide synthase (NOS) in submandibular glands of NOD mice in relation to parotid glands and unrelated tissues. Here we report that NOD mice with incipient signs of secretory dysfunction presented a marked decrease in basal and vasoactive intestinal peptide (VIP)-stimulated NOS activity and a differential expression of NOS I in submandibular glands compared to control BALB/c mice. Similar alterations in NOS I were found in parotid glands but not in brain or spleen of NOD mice. No differences between NOD and controls appeared in NOS II and NOS III expression in any of the tissues studied. © 2001 Academic Press. |
| author |
Rosignoli, Florencia Pérez Leirós, Claudia |
| author_facet |
Rosignoli, Florencia Pérez Leirós, Claudia |
| author_sort |
Rosignoli, Florencia |
| title |
Alterations in nitric oxide synthase activity and expression in submandibular glands of nod mice |
| title_short |
Alterations in nitric oxide synthase activity and expression in submandibular glands of nod mice |
| title_full |
Alterations in nitric oxide synthase activity and expression in submandibular glands of nod mice |
| title_fullStr |
Alterations in nitric oxide synthase activity and expression in submandibular glands of nod mice |
| title_full_unstemmed |
Alterations in nitric oxide synthase activity and expression in submandibular glands of nod mice |
| title_sort |
alterations in nitric oxide synthase activity and expression in submandibular glands of nod mice |
| publishDate |
2001 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15216616_v101_n1_p86_Rosignoli http://hdl.handle.net/20.500.12110/paper_15216616_v101_n1_p86_Rosignoli |
| work_keys_str_mv |
AT rosignoliflorencia alterationsinnitricoxidesynthaseactivityandexpressioninsubmandibularglandsofnodmice AT perezleirosclaudia alterationsinnitricoxidesynthaseactivityandexpressioninsubmandibularglandsofnodmice |
| _version_ |
1768542755778199552 |