Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus
A new triterpene glycoside, pseudocnoside A (1), was isolated from the sea cucumber Pseudocnus dubiosus leoninus. The structure of the new compound was established on the basis of extensive NMR spectroscopic analysis (1H and 13C NMR, 1H,1H-COSY, HMBC, HSQC, TOCSY and NOESY), HR-ESI-MS data and chemi...
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paper:paper_14786419_v28_n4_p213_Careaga2023-06-08T16:18:23Z Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus Careaga Quiroga, Valeria P. Bueno, Carlos Alberto Alche, Laura Edith Maier, Marta Silvia antiproliferative cytotoxic Pseudocnus dubiosus leoninus sulphated triterpene glycosides glycoside hemoiedemosides a patagonicosides b pseudocnoside a triterpene unclassified drug antiproliferative activity article cancer cell culture carbon nuclear magnetic resonance controlled study drug structure Hemioedema spectabilis_ib drug isolation heteronuclear multiple bond correlation heteronuclear single quantum coherence human human cell nonhuman nuclear magnetic resonance spectroscopy nuclear Overhauser effect proton nuclear magnetic resonance Pseudocnus dubiosus leoninus sea cucumber Holothuroidea Pseudocnus dubiosus Psolus Animals Antineoplastic Agents Atlantic Ocean Drug Screening Assays, Antitumor Glycosides HeLa Cells Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Sea Cucumbers Triterpenes A new triterpene glycoside, pseudocnoside A (1), was isolated from the sea cucumber Pseudocnus dubiosus leoninus. The structure of the new compound was established on the basis of extensive NMR spectroscopic analysis (1H and 13C NMR, 1H,1H-COSY, HMBC, HSQC, TOCSY and NOESY), HR-ESI-MS data and chemical transformations. In addition, the cytotoxicity and antiproliferative activities of 1 and structurally related triterpene glycosides isolated from the sea cucumbers Psolus patagonicus and Hemioedema spectabilis were evaluated against cancer cell lines A-549 and HeLa. © 2013 Taylor & Francis. Fil:Careaga, V.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bueno, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Alché, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Maier, M.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14786419_v28_n4_p213_Careaga http://hdl.handle.net/20.500.12110/paper_14786419_v28_n4_p213_Careaga |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
antiproliferative cytotoxic Pseudocnus dubiosus leoninus sulphated triterpene glycosides glycoside hemoiedemosides a patagonicosides b pseudocnoside a triterpene unclassified drug antiproliferative activity article cancer cell culture carbon nuclear magnetic resonance controlled study drug structure Hemioedema spectabilis_ib drug isolation heteronuclear multiple bond correlation heteronuclear single quantum coherence human human cell nonhuman nuclear magnetic resonance spectroscopy nuclear Overhauser effect proton nuclear magnetic resonance Pseudocnus dubiosus leoninus sea cucumber Holothuroidea Pseudocnus dubiosus Psolus Animals Antineoplastic Agents Atlantic Ocean Drug Screening Assays, Antitumor Glycosides HeLa Cells Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Sea Cucumbers Triterpenes |
spellingShingle |
antiproliferative cytotoxic Pseudocnus dubiosus leoninus sulphated triterpene glycosides glycoside hemoiedemosides a patagonicosides b pseudocnoside a triterpene unclassified drug antiproliferative activity article cancer cell culture carbon nuclear magnetic resonance controlled study drug structure Hemioedema spectabilis_ib drug isolation heteronuclear multiple bond correlation heteronuclear single quantum coherence human human cell nonhuman nuclear magnetic resonance spectroscopy nuclear Overhauser effect proton nuclear magnetic resonance Pseudocnus dubiosus leoninus sea cucumber Holothuroidea Pseudocnus dubiosus Psolus Animals Antineoplastic Agents Atlantic Ocean Drug Screening Assays, Antitumor Glycosides HeLa Cells Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Sea Cucumbers Triterpenes Careaga Quiroga, Valeria P. Bueno, Carlos Alberto Alche, Laura Edith Maier, Marta Silvia Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus |
topic_facet |
antiproliferative cytotoxic Pseudocnus dubiosus leoninus sulphated triterpene glycosides glycoside hemoiedemosides a patagonicosides b pseudocnoside a triterpene unclassified drug antiproliferative activity article cancer cell culture carbon nuclear magnetic resonance controlled study drug structure Hemioedema spectabilis_ib drug isolation heteronuclear multiple bond correlation heteronuclear single quantum coherence human human cell nonhuman nuclear magnetic resonance spectroscopy nuclear Overhauser effect proton nuclear magnetic resonance Pseudocnus dubiosus leoninus sea cucumber Holothuroidea Pseudocnus dubiosus Psolus Animals Antineoplastic Agents Atlantic Ocean Drug Screening Assays, Antitumor Glycosides HeLa Cells Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Sea Cucumbers Triterpenes |
description |
A new triterpene glycoside, pseudocnoside A (1), was isolated from the sea cucumber Pseudocnus dubiosus leoninus. The structure of the new compound was established on the basis of extensive NMR spectroscopic analysis (1H and 13C NMR, 1H,1H-COSY, HMBC, HSQC, TOCSY and NOESY), HR-ESI-MS data and chemical transformations. In addition, the cytotoxicity and antiproliferative activities of 1 and structurally related triterpene glycosides isolated from the sea cucumbers Psolus patagonicus and Hemioedema spectabilis were evaluated against cancer cell lines A-549 and HeLa. © 2013 Taylor & Francis. |
author |
Careaga Quiroga, Valeria P. Bueno, Carlos Alberto Alche, Laura Edith Maier, Marta Silvia |
author_facet |
Careaga Quiroga, Valeria P. Bueno, Carlos Alberto Alche, Laura Edith Maier, Marta Silvia |
author_sort |
Careaga Quiroga, Valeria P. |
title |
Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus |
title_short |
Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus |
title_full |
Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus |
title_fullStr |
Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus |
title_full_unstemmed |
Pseudocnoside A, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber Pseudocnus dubiosus leoninus |
title_sort |
pseudocnoside a, a new cytotoxic and antiproliferative triterpene glycoside from the sea cucumber pseudocnus dubiosus leoninus |
publishDate |
2014 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14786419_v28_n4_p213_Careaga http://hdl.handle.net/20.500.12110/paper_14786419_v28_n4_p213_Careaga |
work_keys_str_mv |
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_version_ |
1768542193303158784 |