Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions
Cell movement and intercellular signaling occur simultaneously during the development of tissues, but little is known about how movement affects signaling. Previous theoretical studies have shown that faster moving cells favor synchronization across a population of locally coupled genetic oscillator...
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2012
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14783967_v9_n3_p_Uriu http://hdl.handle.net/20.500.12110/paper_14783967_v9_n3_p_Uriu |
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paper:paper_14783967_v9_n3_p_Uriu2023-06-08T16:18:21Z Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions animal article biological model biological rhythm cell communication cell motion computer simulation human morphogenesis signal transduction Animals Biological Clocks Cell Communication Cell Movement Computer Simulation Humans Models, Biological Morphogenesis Signal Transduction Cell movement and intercellular signaling occur simultaneously during the development of tissues, but little is known about how movement affects signaling. Previous theoretical studies have shown that faster moving cells favor synchronization across a population of locally coupled genetic oscillators. An important assumption in these studies is that cells can immediately interact with their new neighbors after arriving at a new location. However, intercellular interactions in cellular systems may need some time to become fully established. How movement affects synchronization in this situation has not been examined. Here, we develop a coupled phase oscillator model in which we consider cell movement and the gradual recovery of intercellular coupling experienced by a cell after movement, characterized by a moving rate and a coupling recovery rate, respectively. We find (1) an optimal moving rate for synchronization and (2) a critical moving rate above which achieving synchronization is not possible. These results indicate that the extent to which movement enhances synchrony is limited by a gradual recovery of coupling. These findings suggest that the ratio of time scales of movement and signaling recovery is critical for information transfer between moving cells. © 2012 IOP Publishing Ltd. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14783967_v9_n3_p_Uriu http://hdl.handle.net/20.500.12110/paper_14783967_v9_n3_p_Uriu |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
animal article biological model biological rhythm cell communication cell motion computer simulation human morphogenesis signal transduction Animals Biological Clocks Cell Communication Cell Movement Computer Simulation Humans Models, Biological Morphogenesis Signal Transduction |
| spellingShingle |
animal article biological model biological rhythm cell communication cell motion computer simulation human morphogenesis signal transduction Animals Biological Clocks Cell Communication Cell Movement Computer Simulation Humans Models, Biological Morphogenesis Signal Transduction Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions |
| topic_facet |
animal article biological model biological rhythm cell communication cell motion computer simulation human morphogenesis signal transduction Animals Biological Clocks Cell Communication Cell Movement Computer Simulation Humans Models, Biological Morphogenesis Signal Transduction |
| description |
Cell movement and intercellular signaling occur simultaneously during the development of tissues, but little is known about how movement affects signaling. Previous theoretical studies have shown that faster moving cells favor synchronization across a population of locally coupled genetic oscillators. An important assumption in these studies is that cells can immediately interact with their new neighbors after arriving at a new location. However, intercellular interactions in cellular systems may need some time to become fully established. How movement affects synchronization in this situation has not been examined. Here, we develop a coupled phase oscillator model in which we consider cell movement and the gradual recovery of intercellular coupling experienced by a cell after movement, characterized by a moving rate and a coupling recovery rate, respectively. We find (1) an optimal moving rate for synchronization and (2) a critical moving rate above which achieving synchronization is not possible. These results indicate that the extent to which movement enhances synchrony is limited by a gradual recovery of coupling. These findings suggest that the ratio of time scales of movement and signaling recovery is critical for information transfer between moving cells. © 2012 IOP Publishing Ltd. |
| title |
Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions |
| title_short |
Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions |
| title_full |
Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions |
| title_fullStr |
Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions |
| title_full_unstemmed |
Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions |
| title_sort |
optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions |
| publishDate |
2012 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14783967_v9_n3_p_Uriu http://hdl.handle.net/20.500.12110/paper_14783967_v9_n3_p_Uriu |
| _version_ |
1768543576386437120 |