Untangling Galectin-Driven Regulatory Circuits in Autoimmune Inflammation
Although progress has been made in understanding the mechanisms implicated in the pathogenesis of autoimmune inflammation, studies aimed at identifying the mediators of these pathways will be necessary to develop more selective therapies. Galectins, a family of glycan-binding proteins, play central...
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2018
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14714914_v24_n4_p348_Toscano http://hdl.handle.net/20.500.12110/paper_14714914_v24_n4_p348_Toscano |
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paper:paper_14714914_v24_n4_p348_Toscano2023-06-08T16:17:21Z Untangling Galectin-Driven Regulatory Circuits in Autoimmune Inflammation autoimmunity chronic inflammation galectins glycans immunoregulation ecalectin galectin galectin 2 galectin 3 gamma interferon glycan interleukin 10 interleukin 17 interleukin 1beta interleukin 27 tumor necrosis factor biological factor galectin apoptosis astrocyte autoimmune disease CD4+ T lymphocyte CD8+ T lymphocyte collagen-induced arthritis Crohn disease dendritic cell endothelium cell experimental autoimmune encephalomyelitis glycosylation human immunocompetent cell immunological tolerance immunomodulation inflammation inflammatory bowel disease insulin dependent diabetes mellitus intestine flora lymphocytic infiltration macrophage microglia multiple sclerosis nervous system inflammation nonhuman protein carbohydrate interaction protein expression protein function regulatory T lymphocyte Review rheumatoid arthritis systemic lupus erythematosus Th1 cell Th17 cell ulcerative colitis upregulation adverse drug reaction animal autoimmune disease autoimmunity drug effect inflammation metabolism Animals Autoimmune Diseases Autoimmunity Biological Factors Drug-Related Side Effects and Adverse Reactions Galectins Humans Inflammation Although progress has been made in understanding the mechanisms implicated in the pathogenesis of autoimmune inflammation, studies aimed at identifying the mediators of these pathways will be necessary to develop more selective therapies. Galectins, a family of glycan-binding proteins, play central roles in immune cell homeostasis. Whereas some members of this family trigger regulatory programs that promote resolution of inflammation, others contribute to perpetuate autoimmune processes. We discuss the roles of endogenous galectins and their specific glycosylated ligands in shaping autoimmune responses by fueling, extinguishing, or rewiring immune circuits. Understanding the relevance of galectin–glycan interactions in autoimmune inflammation could help to uncover novel pathways of tolerance breakdown, define molecular signatures for patient stratification and therapy responses, and open new avenues for immune intervention. © 2018 Elsevier Ltd 2018 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14714914_v24_n4_p348_Toscano http://hdl.handle.net/20.500.12110/paper_14714914_v24_n4_p348_Toscano |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
autoimmunity chronic inflammation galectins glycans immunoregulation ecalectin galectin galectin 2 galectin 3 gamma interferon glycan interleukin 10 interleukin 17 interleukin 1beta interleukin 27 tumor necrosis factor biological factor galectin apoptosis astrocyte autoimmune disease CD4+ T lymphocyte CD8+ T lymphocyte collagen-induced arthritis Crohn disease dendritic cell endothelium cell experimental autoimmune encephalomyelitis glycosylation human immunocompetent cell immunological tolerance immunomodulation inflammation inflammatory bowel disease insulin dependent diabetes mellitus intestine flora lymphocytic infiltration macrophage microglia multiple sclerosis nervous system inflammation nonhuman protein carbohydrate interaction protein expression protein function regulatory T lymphocyte Review rheumatoid arthritis systemic lupus erythematosus Th1 cell Th17 cell ulcerative colitis upregulation adverse drug reaction animal autoimmune disease autoimmunity drug effect inflammation metabolism Animals Autoimmune Diseases Autoimmunity Biological Factors Drug-Related Side Effects and Adverse Reactions Galectins Humans Inflammation |
| spellingShingle |
autoimmunity chronic inflammation galectins glycans immunoregulation ecalectin galectin galectin 2 galectin 3 gamma interferon glycan interleukin 10 interleukin 17 interleukin 1beta interleukin 27 tumor necrosis factor biological factor galectin apoptosis astrocyte autoimmune disease CD4+ T lymphocyte CD8+ T lymphocyte collagen-induced arthritis Crohn disease dendritic cell endothelium cell experimental autoimmune encephalomyelitis glycosylation human immunocompetent cell immunological tolerance immunomodulation inflammation inflammatory bowel disease insulin dependent diabetes mellitus intestine flora lymphocytic infiltration macrophage microglia multiple sclerosis nervous system inflammation nonhuman protein carbohydrate interaction protein expression protein function regulatory T lymphocyte Review rheumatoid arthritis systemic lupus erythematosus Th1 cell Th17 cell ulcerative colitis upregulation adverse drug reaction animal autoimmune disease autoimmunity drug effect inflammation metabolism Animals Autoimmune Diseases Autoimmunity Biological Factors Drug-Related Side Effects and Adverse Reactions Galectins Humans Inflammation Untangling Galectin-Driven Regulatory Circuits in Autoimmune Inflammation |
| topic_facet |
autoimmunity chronic inflammation galectins glycans immunoregulation ecalectin galectin galectin 2 galectin 3 gamma interferon glycan interleukin 10 interleukin 17 interleukin 1beta interleukin 27 tumor necrosis factor biological factor galectin apoptosis astrocyte autoimmune disease CD4+ T lymphocyte CD8+ T lymphocyte collagen-induced arthritis Crohn disease dendritic cell endothelium cell experimental autoimmune encephalomyelitis glycosylation human immunocompetent cell immunological tolerance immunomodulation inflammation inflammatory bowel disease insulin dependent diabetes mellitus intestine flora lymphocytic infiltration macrophage microglia multiple sclerosis nervous system inflammation nonhuman protein carbohydrate interaction protein expression protein function regulatory T lymphocyte Review rheumatoid arthritis systemic lupus erythematosus Th1 cell Th17 cell ulcerative colitis upregulation adverse drug reaction animal autoimmune disease autoimmunity drug effect inflammation metabolism Animals Autoimmune Diseases Autoimmunity Biological Factors Drug-Related Side Effects and Adverse Reactions Galectins Humans Inflammation |
| description |
Although progress has been made in understanding the mechanisms implicated in the pathogenesis of autoimmune inflammation, studies aimed at identifying the mediators of these pathways will be necessary to develop more selective therapies. Galectins, a family of glycan-binding proteins, play central roles in immune cell homeostasis. Whereas some members of this family trigger regulatory programs that promote resolution of inflammation, others contribute to perpetuate autoimmune processes. We discuss the roles of endogenous galectins and their specific glycosylated ligands in shaping autoimmune responses by fueling, extinguishing, or rewiring immune circuits. Understanding the relevance of galectin–glycan interactions in autoimmune inflammation could help to uncover novel pathways of tolerance breakdown, define molecular signatures for patient stratification and therapy responses, and open new avenues for immune intervention. © 2018 Elsevier Ltd |
| title |
Untangling Galectin-Driven Regulatory Circuits in Autoimmune Inflammation |
| title_short |
Untangling Galectin-Driven Regulatory Circuits in Autoimmune Inflammation |
| title_full |
Untangling Galectin-Driven Regulatory Circuits in Autoimmune Inflammation |
| title_fullStr |
Untangling Galectin-Driven Regulatory Circuits in Autoimmune Inflammation |
| title_full_unstemmed |
Untangling Galectin-Driven Regulatory Circuits in Autoimmune Inflammation |
| title_sort |
untangling galectin-driven regulatory circuits in autoimmune inflammation |
| publishDate |
2018 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14714914_v24_n4_p348_Toscano http://hdl.handle.net/20.500.12110/paper_14714914_v24_n4_p348_Toscano |
| _version_ |
1768542472158314496 |