Genetic basis of wing morphogenesis in Drosophila: Sexual dimorphism and non-allometric effects of shape variation
Background: The Drosophila wing represents a particularly appropriate model to investigate the developmental control of phenotypic variation. Previous studies which aimed to identify candidate genes for wing morphology demonstrated that the genetic basis of wing shape variation in D. melanogaster is...
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1471213X_v11_n_p_Carreira http://hdl.handle.net/20.500.12110/paper_1471213X_v11_n_p_Carreira |
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paper:paper_1471213X_v11_n_p_Carreira2023-06-08T16:17:11Z Genetic basis of wing morphogenesis in Drosophila: Sexual dimorphism and non-allometric effects of shape variation Carreira, Valeria Paula Soto, Ignacio M. Mensch, Julián Fanara, Juan Jose Drosophila melanogaster animal article congenital malformation Drosophila melanogaster female forelimb genetics genotype histology male morphogenesis morphometrics mutation phenotype physiology sexual development Animals Body Weights and Measures Drosophila melanogaster Female Genotype Male Morphogenesis Mutation Phenotype Sex Characteristics Wing Background: The Drosophila wing represents a particularly appropriate model to investigate the developmental control of phenotypic variation. Previous studies which aimed to identify candidate genes for wing morphology demonstrated that the genetic basis of wing shape variation in D. melanogaster is composed of numerous genetic factors causing small, additive effects. In this study, we analyzed wing shape in males and females from 191 lines of D. melanogaster, homozygous for a single P-element insertion, using geometric morphometrics techniques. The analysis allowed us to identify known and novel candidate genes that may contribute to the expression of wing shape in each sex separately and to compare them to candidate genes affecting wing size which have been identified previously using the same lines. Results: Our results indicate that more than 63% of induced mutations affected wing shape in one or both sexes, although only 33% showed significant differences in both males and females. The joint analysis of wing size and shape revealed that only 19% of the P-element insertions caused coincident effects on both components of wing form in one or both sexes. Further morphometrical analyses revealed that the intersection between veins showed the smallest displacements in the proximal region of the wing. Finally, we observed that mutations causing general deformations were more common than expected in both sexes whereas the opposite occurred with those generating local changes. For most of the 94 candidate genes identified, this seems to be the first record relating them with wing shape variation. Conclusions: Our results support the idea that the genetic architecture of wing shape is complex with many different genes contributing to the trait in a sexually dimorphic manner. This polygenic basis, which is relatively independent from that of wing size, is composed of genes generally involved in development and/or metabolic functions, especially related to the regulation of different cellular processes such as motility, adhesion, communication and signal transduction. This study suggests that understanding the genetic basis of wing shape requires merging the regulation of vein patterning by signalling pathways with processes that occur during wing development at the cellular level. © 2011 Carreira et al; licensee BioMed Central Ltd. Fil:Carreira, V.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Soto, I.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Mensch, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Fanara, J.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1471213X_v11_n_p_Carreira http://hdl.handle.net/20.500.12110/paper_1471213X_v11_n_p_Carreira |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Drosophila melanogaster animal article congenital malformation Drosophila melanogaster female forelimb genetics genotype histology male morphogenesis morphometrics mutation phenotype physiology sexual development Animals Body Weights and Measures Drosophila melanogaster Female Genotype Male Morphogenesis Mutation Phenotype Sex Characteristics Wing |
| spellingShingle |
Drosophila melanogaster animal article congenital malformation Drosophila melanogaster female forelimb genetics genotype histology male morphogenesis morphometrics mutation phenotype physiology sexual development Animals Body Weights and Measures Drosophila melanogaster Female Genotype Male Morphogenesis Mutation Phenotype Sex Characteristics Wing Carreira, Valeria Paula Soto, Ignacio M. Mensch, Julián Fanara, Juan Jose Genetic basis of wing morphogenesis in Drosophila: Sexual dimorphism and non-allometric effects of shape variation |
| topic_facet |
Drosophila melanogaster animal article congenital malformation Drosophila melanogaster female forelimb genetics genotype histology male morphogenesis morphometrics mutation phenotype physiology sexual development Animals Body Weights and Measures Drosophila melanogaster Female Genotype Male Morphogenesis Mutation Phenotype Sex Characteristics Wing |
| description |
Background: The Drosophila wing represents a particularly appropriate model to investigate the developmental control of phenotypic variation. Previous studies which aimed to identify candidate genes for wing morphology demonstrated that the genetic basis of wing shape variation in D. melanogaster is composed of numerous genetic factors causing small, additive effects. In this study, we analyzed wing shape in males and females from 191 lines of D. melanogaster, homozygous for a single P-element insertion, using geometric morphometrics techniques. The analysis allowed us to identify known and novel candidate genes that may contribute to the expression of wing shape in each sex separately and to compare them to candidate genes affecting wing size which have been identified previously using the same lines. Results: Our results indicate that more than 63% of induced mutations affected wing shape in one or both sexes, although only 33% showed significant differences in both males and females. The joint analysis of wing size and shape revealed that only 19% of the P-element insertions caused coincident effects on both components of wing form in one or both sexes. Further morphometrical analyses revealed that the intersection between veins showed the smallest displacements in the proximal region of the wing. Finally, we observed that mutations causing general deformations were more common than expected in both sexes whereas the opposite occurred with those generating local changes. For most of the 94 candidate genes identified, this seems to be the first record relating them with wing shape variation. Conclusions: Our results support the idea that the genetic architecture of wing shape is complex with many different genes contributing to the trait in a sexually dimorphic manner. This polygenic basis, which is relatively independent from that of wing size, is composed of genes generally involved in development and/or metabolic functions, especially related to the regulation of different cellular processes such as motility, adhesion, communication and signal transduction. This study suggests that understanding the genetic basis of wing shape requires merging the regulation of vein patterning by signalling pathways with processes that occur during wing development at the cellular level. © 2011 Carreira et al; licensee BioMed Central Ltd. |
| author |
Carreira, Valeria Paula Soto, Ignacio M. Mensch, Julián Fanara, Juan Jose |
| author_facet |
Carreira, Valeria Paula Soto, Ignacio M. Mensch, Julián Fanara, Juan Jose |
| author_sort |
Carreira, Valeria Paula |
| title |
Genetic basis of wing morphogenesis in Drosophila: Sexual dimorphism and non-allometric effects of shape variation |
| title_short |
Genetic basis of wing morphogenesis in Drosophila: Sexual dimorphism and non-allometric effects of shape variation |
| title_full |
Genetic basis of wing morphogenesis in Drosophila: Sexual dimorphism and non-allometric effects of shape variation |
| title_fullStr |
Genetic basis of wing morphogenesis in Drosophila: Sexual dimorphism and non-allometric effects of shape variation |
| title_full_unstemmed |
Genetic basis of wing morphogenesis in Drosophila: Sexual dimorphism and non-allometric effects of shape variation |
| title_sort |
genetic basis of wing morphogenesis in drosophila: sexual dimorphism and non-allometric effects of shape variation |
| publishDate |
2011 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1471213X_v11_n_p_Carreira http://hdl.handle.net/20.500.12110/paper_1471213X_v11_n_p_Carreira |
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