Mouse models of altered gonadotrophin action: Insight into male reproductive disorders
The advent of technologies to genetically manipulate the mouse genome has revolutionised research approaches, providing a unique platform to study the causality of reproductive disorders in vivo. With the relative ease of generating genetically modified (GM) mouse models, the last two decades have y...
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2014
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14701626_v148_n4_pR63_Jonas http://hdl.handle.net/20.500.12110/paper_14701626_v148_n4_pR63_Jonas |
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paper:paper_14701626_v148_n4_pR63_Jonas2023-06-08T16:17:05Z Mouse models of altered gonadotrophin action: Insight into male reproductive disorders chorionic gonadotropin follitropin follitropin receptor gonadotropin luteinizing hormone luteinizing hormone receptor testosterone follitropin follitropin receptor gonadotropin luteinizing hormone luteinizing hormone receptor androgen therapy gain of function mutation genetically engineered mouse strain hormone action loss of function mutation male male genital system disease nonhuman Review animal genetics genotype male infertility metabolism mouse pathophysiology phenotype reproduction signal transduction transgenic mouse Animals Follicle Stimulating Hormone Genotype Gonadotropins Infertility, Male Luteinizing Hormone Male Mice Mice, Transgenic Phenotype Receptors, FSH Receptors, LH Reproduction Signal Transduction The advent of technologies to genetically manipulate the mouse genome has revolutionised research approaches, providing a unique platform to study the causality of reproductive disorders in vivo. With the relative ease of generating genetically modified (GM) mouse models, the last two decades have yielded multiple loss-of-function and gain-of-function mutation mouse models to explore the role of gonadotrophins and their receptors in reproductive pathologies. This work has provided key insights into the molecular mechanisms underlying reproductive disorders with altered gonadotrophin action, revealing the fundamental roles of these pituitary hormones and their receptors in the hypothalamic-pituitary-gonadal axis. This review will describe GM mouse models of gonadotrophins and their receptors with enhanced or diminished actions, specifically focusing on the male. We will discuss the mechanistic insights gained from these models into male reproductive disorders, and the relationship and understanding provided into male human reproductive disorders originating from altered gonadotrophin action. © 2014 Society for Reproduction and Fertility. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14701626_v148_n4_pR63_Jonas http://hdl.handle.net/20.500.12110/paper_14701626_v148_n4_pR63_Jonas |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
chorionic gonadotropin follitropin follitropin receptor gonadotropin luteinizing hormone luteinizing hormone receptor testosterone follitropin follitropin receptor gonadotropin luteinizing hormone luteinizing hormone receptor androgen therapy gain of function mutation genetically engineered mouse strain hormone action loss of function mutation male male genital system disease nonhuman Review animal genetics genotype male infertility metabolism mouse pathophysiology phenotype reproduction signal transduction transgenic mouse Animals Follicle Stimulating Hormone Genotype Gonadotropins Infertility, Male Luteinizing Hormone Male Mice Mice, Transgenic Phenotype Receptors, FSH Receptors, LH Reproduction Signal Transduction |
| spellingShingle |
chorionic gonadotropin follitropin follitropin receptor gonadotropin luteinizing hormone luteinizing hormone receptor testosterone follitropin follitropin receptor gonadotropin luteinizing hormone luteinizing hormone receptor androgen therapy gain of function mutation genetically engineered mouse strain hormone action loss of function mutation male male genital system disease nonhuman Review animal genetics genotype male infertility metabolism mouse pathophysiology phenotype reproduction signal transduction transgenic mouse Animals Follicle Stimulating Hormone Genotype Gonadotropins Infertility, Male Luteinizing Hormone Male Mice Mice, Transgenic Phenotype Receptors, FSH Receptors, LH Reproduction Signal Transduction Mouse models of altered gonadotrophin action: Insight into male reproductive disorders |
| topic_facet |
chorionic gonadotropin follitropin follitropin receptor gonadotropin luteinizing hormone luteinizing hormone receptor testosterone follitropin follitropin receptor gonadotropin luteinizing hormone luteinizing hormone receptor androgen therapy gain of function mutation genetically engineered mouse strain hormone action loss of function mutation male male genital system disease nonhuman Review animal genetics genotype male infertility metabolism mouse pathophysiology phenotype reproduction signal transduction transgenic mouse Animals Follicle Stimulating Hormone Genotype Gonadotropins Infertility, Male Luteinizing Hormone Male Mice Mice, Transgenic Phenotype Receptors, FSH Receptors, LH Reproduction Signal Transduction |
| description |
The advent of technologies to genetically manipulate the mouse genome has revolutionised research approaches, providing a unique platform to study the causality of reproductive disorders in vivo. With the relative ease of generating genetically modified (GM) mouse models, the last two decades have yielded multiple loss-of-function and gain-of-function mutation mouse models to explore the role of gonadotrophins and their receptors in reproductive pathologies. This work has provided key insights into the molecular mechanisms underlying reproductive disorders with altered gonadotrophin action, revealing the fundamental roles of these pituitary hormones and their receptors in the hypothalamic-pituitary-gonadal axis. This review will describe GM mouse models of gonadotrophins and their receptors with enhanced or diminished actions, specifically focusing on the male. We will discuss the mechanistic insights gained from these models into male reproductive disorders, and the relationship and understanding provided into male human reproductive disorders originating from altered gonadotrophin action. © 2014 Society for Reproduction and Fertility. |
| title |
Mouse models of altered gonadotrophin action: Insight into male reproductive disorders |
| title_short |
Mouse models of altered gonadotrophin action: Insight into male reproductive disorders |
| title_full |
Mouse models of altered gonadotrophin action: Insight into male reproductive disorders |
| title_fullStr |
Mouse models of altered gonadotrophin action: Insight into male reproductive disorders |
| title_full_unstemmed |
Mouse models of altered gonadotrophin action: Insight into male reproductive disorders |
| title_sort |
mouse models of altered gonadotrophin action: insight into male reproductive disorders |
| publishDate |
2014 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14701626_v148_n4_pR63_Jonas http://hdl.handle.net/20.500.12110/paper_14701626_v148_n4_pR63_Jonas |
| _version_ |
1768542612634992640 |