Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states

Interaction between norharmane and three different 2′-deoxynucleotides (dNMP) (2′-deoxyguanosine 5′-monophosphate (dGMP), 2′-deoxyadenosine 5′-monophosphate (dAMP) and 2′-deoxycytidine 5′-monophosphate (dCMP)), in aqueous solution, was studied in the ground state by means of UV-vis and 1H-NMR spectr...

Descripción completa

Detalles Bibliográficos
Publicado: 2014
Materias:
pH
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14639076_v16_n31_p16547_Gonzalez
http://hdl.handle.net/20.500.12110/paper_14639076_v16_n31_p16547_Gonzalez
Aporte de:
id paper:paper_14639076_v16_n31_p16547_Gonzalez
record_format dspace
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic indole derivative
nucleotide
chemical structure
chemistry
pH
procedures
proton nuclear magnetic resonance
spectroscopy
Hydrogen-Ion Concentration
Indoles
Models, Molecular
Nucleotides
Proton Magnetic Resonance Spectroscopy
Spectrum Analysis
spellingShingle indole derivative
nucleotide
chemical structure
chemistry
pH
procedures
proton nuclear magnetic resonance
spectroscopy
Hydrogen-Ion Concentration
Indoles
Models, Molecular
Nucleotides
Proton Magnetic Resonance Spectroscopy
Spectrum Analysis
Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states
topic_facet indole derivative
nucleotide
chemical structure
chemistry
pH
procedures
proton nuclear magnetic resonance
spectroscopy
Hydrogen-Ion Concentration
Indoles
Models, Molecular
Nucleotides
Proton Magnetic Resonance Spectroscopy
Spectrum Analysis
description Interaction between norharmane and three different 2′-deoxynucleotides (dNMP) (2′-deoxyguanosine 5′-monophosphate (dGMP), 2′-deoxyadenosine 5′-monophosphate (dAMP) and 2′-deoxycytidine 5′-monophosphate (dCMP)), in aqueous solution, was studied in the ground state by means of UV-vis and 1H-NMR spectroscopy and in the first electronic excited state using steady-state and time-resolved fluorescence spectroscopy. In all cases, the norharmane-dNMP interaction dependence on the pH was examined. Possible mechanisms for the interaction of both ground and electronic excited states of norharmane with nucleotides are discussed. Spectroscopic, molecular modeling and chemometric analysis were performed to further characterize the chemical structure of the complexes formed and to get additional information concerning the interaction between dNMPs and norharmane. © the Partner Organisations 2014.
title Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states
title_short Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states
title_full Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states
title_fullStr Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states
title_full_unstemmed Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states
title_sort determining the molecular basis for the ph-dependent interaction between 2′-deoxynucleotides and 9h-pyrido[3,4-b]indole in its ground and electronic excited states
publishDate 2014
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14639076_v16_n31_p16547_Gonzalez
http://hdl.handle.net/20.500.12110/paper_14639076_v16_n31_p16547_Gonzalez
bdutipo_str Repositorios
_version_ 1764820567757684739