Nitric oxide in liver transplantation
Liver transplantation is the only therapeutic option for patients with end-stage liver disease. Nitric oxide, a free radical produced from L-arginine, a potent vasodilator, also inhibits platelet adhesion and aggregation, reduces adhesion of leukocytes to the endothelium and suppresses proliferation...
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2001
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14346621_v39_n10_p932_Zanaro http://hdl.handle.net/20.500.12110/paper_14346621_v39_n10_p932_Zanaro |
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paper:paper_14346621_v39_n10_p932_Zanaro2023-06-08T16:15:37Z Nitric oxide in liver transplantation Inducible (iNOS) Liver transplantation Nitric oxide Nitric oxide synthase alanine aminotransferase albumin arginine aspartate aminotransferase bilirubin cholinesterase creatinine cytokine free radical glucose lipopolysaccharide liver enzyme nitric oxide nitric oxide synthase plasma protein adult alanine aminotransferase blood level article aspartate aminotransferase blood level blood level cell proliferation cholinesterase blood level clinical article controlled study endothelium female human inhibition kinetics ischemia kidney failure Kupffer cell leukocyte adherence liver circulation liver transplantation male priority journal reperfusion injury sampling shock smooth muscle fiber thrombocyte thrombocyte adhesion thrombocyte aggregation vascular endothelium vascular smooth muscle vasodilatation Adolescent Adult Alanine Transaminase Aspartate Aminotransferases Bilirubin Blood Glucose Blood Proteins Cholinesterases Creatinine Female Humans Liver Liver Failure Liver Transplantation Male Middle Aged Nitric Oxide Nitric Oxide Synthase Nitric Oxide Synthase Type II Serum Albumin Liver transplantation is the only therapeutic option for patients with end-stage liver disease. Nitric oxide, a free radical produced from L-arginine, a potent vasodilator, also inhibits platelet adhesion and aggregation, reduces adhesion of leukocytes to the endothelium and suppresses proliferation of vascular smooth muscle cells. The inducible form of the nitric oxide synthase may generate large quantities of nitric oxide, and may be induced by the action of cytokines and lipopolysaccharides. Nitric oxide can be released from the hepatic vascular endothelium, platelets and Kupffer cells as a response to ischemia-reperfusion injury and circulatory shock. We analyzed the relationships between the levels of nitric oxide, hepatic enzymes and other clinical parameters (glucose, total proteins, total bilirubin, creatinine, albumin) obtained in serum samples before liver transplantation and every 48 h till day 15 in 15 patients aged 40 ± 13 years. Aspartate aminotransferase and alanine aminotransferase levels changed from high at the beginning, to almost normal at the end of the study, cholinesterase levels remained decreased throughout the study and nitric oxide remained high, never reaching normal values. 2001 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14346621_v39_n10_p932_Zanaro http://hdl.handle.net/20.500.12110/paper_14346621_v39_n10_p932_Zanaro |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Inducible (iNOS) Liver transplantation Nitric oxide Nitric oxide synthase alanine aminotransferase albumin arginine aspartate aminotransferase bilirubin cholinesterase creatinine cytokine free radical glucose lipopolysaccharide liver enzyme nitric oxide nitric oxide synthase plasma protein adult alanine aminotransferase blood level article aspartate aminotransferase blood level blood level cell proliferation cholinesterase blood level clinical article controlled study endothelium female human inhibition kinetics ischemia kidney failure Kupffer cell leukocyte adherence liver circulation liver transplantation male priority journal reperfusion injury sampling shock smooth muscle fiber thrombocyte thrombocyte adhesion thrombocyte aggregation vascular endothelium vascular smooth muscle vasodilatation Adolescent Adult Alanine Transaminase Aspartate Aminotransferases Bilirubin Blood Glucose Blood Proteins Cholinesterases Creatinine Female Humans Liver Liver Failure Liver Transplantation Male Middle Aged Nitric Oxide Nitric Oxide Synthase Nitric Oxide Synthase Type II Serum Albumin |
| spellingShingle |
Inducible (iNOS) Liver transplantation Nitric oxide Nitric oxide synthase alanine aminotransferase albumin arginine aspartate aminotransferase bilirubin cholinesterase creatinine cytokine free radical glucose lipopolysaccharide liver enzyme nitric oxide nitric oxide synthase plasma protein adult alanine aminotransferase blood level article aspartate aminotransferase blood level blood level cell proliferation cholinesterase blood level clinical article controlled study endothelium female human inhibition kinetics ischemia kidney failure Kupffer cell leukocyte adherence liver circulation liver transplantation male priority journal reperfusion injury sampling shock smooth muscle fiber thrombocyte thrombocyte adhesion thrombocyte aggregation vascular endothelium vascular smooth muscle vasodilatation Adolescent Adult Alanine Transaminase Aspartate Aminotransferases Bilirubin Blood Glucose Blood Proteins Cholinesterases Creatinine Female Humans Liver Liver Failure Liver Transplantation Male Middle Aged Nitric Oxide Nitric Oxide Synthase Nitric Oxide Synthase Type II Serum Albumin Nitric oxide in liver transplantation |
| topic_facet |
Inducible (iNOS) Liver transplantation Nitric oxide Nitric oxide synthase alanine aminotransferase albumin arginine aspartate aminotransferase bilirubin cholinesterase creatinine cytokine free radical glucose lipopolysaccharide liver enzyme nitric oxide nitric oxide synthase plasma protein adult alanine aminotransferase blood level article aspartate aminotransferase blood level blood level cell proliferation cholinesterase blood level clinical article controlled study endothelium female human inhibition kinetics ischemia kidney failure Kupffer cell leukocyte adherence liver circulation liver transplantation male priority journal reperfusion injury sampling shock smooth muscle fiber thrombocyte thrombocyte adhesion thrombocyte aggregation vascular endothelium vascular smooth muscle vasodilatation Adolescent Adult Alanine Transaminase Aspartate Aminotransferases Bilirubin Blood Glucose Blood Proteins Cholinesterases Creatinine Female Humans Liver Liver Failure Liver Transplantation Male Middle Aged Nitric Oxide Nitric Oxide Synthase Nitric Oxide Synthase Type II Serum Albumin |
| description |
Liver transplantation is the only therapeutic option for patients with end-stage liver disease. Nitric oxide, a free radical produced from L-arginine, a potent vasodilator, also inhibits platelet adhesion and aggregation, reduces adhesion of leukocytes to the endothelium and suppresses proliferation of vascular smooth muscle cells. The inducible form of the nitric oxide synthase may generate large quantities of nitric oxide, and may be induced by the action of cytokines and lipopolysaccharides. Nitric oxide can be released from the hepatic vascular endothelium, platelets and Kupffer cells as a response to ischemia-reperfusion injury and circulatory shock. We analyzed the relationships between the levels of nitric oxide, hepatic enzymes and other clinical parameters (glucose, total proteins, total bilirubin, creatinine, albumin) obtained in serum samples before liver transplantation and every 48 h till day 15 in 15 patients aged 40 ± 13 years. Aspartate aminotransferase and alanine aminotransferase levels changed from high at the beginning, to almost normal at the end of the study, cholinesterase levels remained decreased throughout the study and nitric oxide remained high, never reaching normal values. |
| title |
Nitric oxide in liver transplantation |
| title_short |
Nitric oxide in liver transplantation |
| title_full |
Nitric oxide in liver transplantation |
| title_fullStr |
Nitric oxide in liver transplantation |
| title_full_unstemmed |
Nitric oxide in liver transplantation |
| title_sort |
nitric oxide in liver transplantation |
| publishDate |
2001 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14346621_v39_n10_p932_Zanaro http://hdl.handle.net/20.500.12110/paper_14346621_v39_n10_p932_Zanaro |
| _version_ |
1768543149036142592 |