Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi

Glutathionylspermidine synthase (GSS) is a crucial enzyme in the trypanothione biosynthetic pathway and is also an interesting molecular target for drug design. We synthesized a series of amides of a glutathione analogue (L-γ-Glu-L-Leu-Gly-NHR) where R are linear alkyl groups. All of these drugs exh...

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Autores principales:	Ravaschino, Esteban Luis, Rodríguez, Juan Bautista
Publicado:	2003
Materias:	American trypanosomiasis Glutathionylspermidine synthase Trypanosoma cruzi Trypanothione gamma glutamyl alpha benzyl ester leucylgylcyl n 1 butylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 heptylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 hexylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 octylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 pentylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 propylamide gamma glutamyl alpha benzyl ester leucylgylcyl n ethylamide gamma glutamyl alpha benzyl ester leucylgylcyl n methylamide glutathione derivative glutathionylspermidine synthase n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 butylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 heptylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 hexylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 octylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 pentylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 propylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n ethylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n methylamide spermidine synthase tripeptide derivative unclassified drug article Chagas disease drug screening drug structure nonhuman peptide synthesis
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14246376_v2003_n10_p298_Ravaschino http://hdl.handle.net/20.500.12110/paper_14246376_v2003_n10_p298_Ravaschino
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_14246376_v2003_n10_p298_Ravaschino
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spelling	paper:paper_14246376_v2003_n10_p298_Ravaschino2023-06-08T16:13:52Z Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi Ravaschino, Esteban Luis Rodríguez, Juan Bautista American trypanosomiasis Glutathionylspermidine synthase Trypanosoma cruzi Trypanothione gamma glutamyl alpha benzyl ester leucylgylcyl n 1 butylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 heptylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 hexylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 octylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 pentylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 propylamide gamma glutamyl alpha benzyl ester leucylgylcyl n ethylamide gamma glutamyl alpha benzyl ester leucylgylcyl n methylamide glutathione derivative glutathionylspermidine synthase n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 butylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 heptylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 hexylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 octylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 pentylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 propylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n ethylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n methylamide spermidine synthase tripeptide derivative unclassified drug article Chagas disease drug screening drug structure nonhuman peptide synthesis Trypanosoma cruzi Glutathionylspermidine synthase (GSS) is a crucial enzyme in the trypanothione biosynthetic pathway and is also an interesting molecular target for drug design. We synthesized a series of amides of a glutathione analogue (L-γ-Glu-L-Leu-Gly-NHR) where R are linear alkyl groups. All of these drugs exhibited marginal biological activity against the responsible agent of Chagas' disease, the protozoan Trypanosoma cruzi. Fil:Ravaschino, E.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Rodriguez, J.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2003 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14246376_v2003_n10_p298_Ravaschino http://hdl.handle.net/20.500.12110/paper_14246376_v2003_n10_p298_Ravaschino
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	American trypanosomiasis Glutathionylspermidine synthase Trypanosoma cruzi Trypanothione gamma glutamyl alpha benzyl ester leucylgylcyl n 1 butylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 heptylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 hexylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 octylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 pentylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 propylamide gamma glutamyl alpha benzyl ester leucylgylcyl n ethylamide gamma glutamyl alpha benzyl ester leucylgylcyl n methylamide glutathione derivative glutathionylspermidine synthase n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 butylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 heptylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 hexylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 octylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 pentylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 propylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n ethylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n methylamide spermidine synthase tripeptide derivative unclassified drug article Chagas disease drug screening drug structure nonhuman peptide synthesis Trypanosoma cruzi
spellingShingle	American trypanosomiasis Glutathionylspermidine synthase Trypanosoma cruzi Trypanothione gamma glutamyl alpha benzyl ester leucylgylcyl n 1 butylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 heptylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 hexylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 octylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 pentylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 propylamide gamma glutamyl alpha benzyl ester leucylgylcyl n ethylamide gamma glutamyl alpha benzyl ester leucylgylcyl n methylamide glutathione derivative glutathionylspermidine synthase n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 butylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 heptylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 hexylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 octylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 pentylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 propylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n ethylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n methylamide spermidine synthase tripeptide derivative unclassified drug article Chagas disease drug screening drug structure nonhuman peptide synthesis Trypanosoma cruzi Ravaschino, Esteban Luis Rodríguez, Juan Bautista Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi
topic_facet	American trypanosomiasis Glutathionylspermidine synthase Trypanosoma cruzi Trypanothione gamma glutamyl alpha benzyl ester leucylgylcyl n 1 butylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 heptylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 hexylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 octylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 pentylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 propylamide gamma glutamyl alpha benzyl ester leucylgylcyl n ethylamide gamma glutamyl alpha benzyl ester leucylgylcyl n methylamide glutathione derivative glutathionylspermidine synthase n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 butylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 heptylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 hexylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 octylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 pentylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 propylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n ethylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n methylamide spermidine synthase tripeptide derivative unclassified drug article Chagas disease drug screening drug structure nonhuman peptide synthesis Trypanosoma cruzi
description	Glutathionylspermidine synthase (GSS) is a crucial enzyme in the trypanothione biosynthetic pathway and is also an interesting molecular target for drug design. We synthesized a series of amides of a glutathione analogue (L-γ-Glu-L-Leu-Gly-NHR) where R are linear alkyl groups. All of these drugs exhibited marginal biological activity against the responsible agent of Chagas' disease, the protozoan Trypanosoma cruzi.
author	Ravaschino, Esteban Luis Rodríguez, Juan Bautista
author_facet	Ravaschino, Esteban Luis Rodríguez, Juan Bautista
author_sort	Ravaschino, Esteban Luis
title	Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi
title_short	Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi
title_full	Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi
title_fullStr	Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi
title_full_unstemmed	Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi
title_sort	synthesis and biological evaluation of glutathione-like tripeptidesagainsttrypanosoma cruzi
publishDate	2003
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14246376_v2003_n10_p298_Ravaschino http://hdl.handle.net/20.500.12110/paper_14246376_v2003_n10_p298_Ravaschino
work_keys_str_mv	AT ravaschinoestebanluis synthesisandbiologicalevaluationofglutathioneliketripeptidesagainsttrypanosomacruzi AT rodriguezjuanbautista synthesisandbiologicalevaluationofglutathioneliketripeptidesagainsttrypanosomacruzi
_version_	1768544379853602816

Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi

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