Epigenetics: New questions on the response to hypoxia
Reduction in oxygen levels below normal concentrations plays important roles in different normal and pathological conditions, such as development, tumorigenesis, chronic kidney disease and stroke. Organisms exposed to hypoxia trigger changes at both cellular and systemic levels to recover oxygen hom...
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2011
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14220067_v12_n7_p4705_PerezPerri http://hdl.handle.net/20.500.12110/paper_14220067_v12_n7_p4705_PerezPerri |
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paper:paper_14220067_v12_n7_p4705_PerezPerri2023-06-08T16:13:48Z Epigenetics: New questions on the response to hypoxia Acevedo, Julieta María Wappner, Pablo Chromatin HIF Histone Jumonji Oxygen Stress histone acetyltransferase histone acetyltransferase PCAF histone deacetylase histone deacetylase 1 histone deacetylase 4 histone deacetylase 5 histone deacetylase 7 histone demethylase hypoxia inducible factor hypoxia inducible factor 1alpha hypoxia inducible factor 2alpha sirtuin 1 chromatin histone histone acetyltransferase histone deacetylase chromatin assembly and disassembly chromatin structure DNA methylation epigenetics gene activation gene expression regulation gene induction gene repression histone acetylation histone methylation histone modification homeostasis hypoxia nonhuman review transcription initiation animal anoxia chemistry chromatin genetics human metabolism Mammalia Animals Anoxia Chromatin Epigenomics Histone Acetyltransferases Histone Deacetylases Histones Humans Reduction in oxygen levels below normal concentrations plays important roles in different normal and pathological conditions, such as development, tumorigenesis, chronic kidney disease and stroke. Organisms exposed to hypoxia trigger changes at both cellular and systemic levels to recover oxygen homeostasis. Most of these processes are mediated by Hypoxia Inducible Factors, HIFs, a family of transcription factors that directly induce the expression of several hundred genes in mammalian cells. Although different aspects of HIF regulation are well known, it is still unclear by which precise mechanism HIFs activate transcription of their target genes. Concomitantly, hypoxia provokes a dramatic decrease of general transcription that seems to rely in part on epigenetic changes through a poorly understood mechanism. In this review we discuss the current knowledge on chromatin changes involved in HIF dependent gene activation, as well as on other epigenetic changes, not necessarily linked to HIF that take place under hypoxic conditions. © 2011 by the authors. Fil:Acevedo, J.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Wappner, P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14220067_v12_n7_p4705_PerezPerri http://hdl.handle.net/20.500.12110/paper_14220067_v12_n7_p4705_PerezPerri |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Chromatin HIF Histone Jumonji Oxygen Stress histone acetyltransferase histone acetyltransferase PCAF histone deacetylase histone deacetylase 1 histone deacetylase 4 histone deacetylase 5 histone deacetylase 7 histone demethylase hypoxia inducible factor hypoxia inducible factor 1alpha hypoxia inducible factor 2alpha sirtuin 1 chromatin histone histone acetyltransferase histone deacetylase chromatin assembly and disassembly chromatin structure DNA methylation epigenetics gene activation gene expression regulation gene induction gene repression histone acetylation histone methylation histone modification homeostasis hypoxia nonhuman review transcription initiation animal anoxia chemistry chromatin genetics human metabolism Mammalia Animals Anoxia Chromatin Epigenomics Histone Acetyltransferases Histone Deacetylases Histones Humans |
| spellingShingle |
Chromatin HIF Histone Jumonji Oxygen Stress histone acetyltransferase histone acetyltransferase PCAF histone deacetylase histone deacetylase 1 histone deacetylase 4 histone deacetylase 5 histone deacetylase 7 histone demethylase hypoxia inducible factor hypoxia inducible factor 1alpha hypoxia inducible factor 2alpha sirtuin 1 chromatin histone histone acetyltransferase histone deacetylase chromatin assembly and disassembly chromatin structure DNA methylation epigenetics gene activation gene expression regulation gene induction gene repression histone acetylation histone methylation histone modification homeostasis hypoxia nonhuman review transcription initiation animal anoxia chemistry chromatin genetics human metabolism Mammalia Animals Anoxia Chromatin Epigenomics Histone Acetyltransferases Histone Deacetylases Histones Humans Acevedo, Julieta María Wappner, Pablo Epigenetics: New questions on the response to hypoxia |
| topic_facet |
Chromatin HIF Histone Jumonji Oxygen Stress histone acetyltransferase histone acetyltransferase PCAF histone deacetylase histone deacetylase 1 histone deacetylase 4 histone deacetylase 5 histone deacetylase 7 histone demethylase hypoxia inducible factor hypoxia inducible factor 1alpha hypoxia inducible factor 2alpha sirtuin 1 chromatin histone histone acetyltransferase histone deacetylase chromatin assembly and disassembly chromatin structure DNA methylation epigenetics gene activation gene expression regulation gene induction gene repression histone acetylation histone methylation histone modification homeostasis hypoxia nonhuman review transcription initiation animal anoxia chemistry chromatin genetics human metabolism Mammalia Animals Anoxia Chromatin Epigenomics Histone Acetyltransferases Histone Deacetylases Histones Humans |
| description |
Reduction in oxygen levels below normal concentrations plays important roles in different normal and pathological conditions, such as development, tumorigenesis, chronic kidney disease and stroke. Organisms exposed to hypoxia trigger changes at both cellular and systemic levels to recover oxygen homeostasis. Most of these processes are mediated by Hypoxia Inducible Factors, HIFs, a family of transcription factors that directly induce the expression of several hundred genes in mammalian cells. Although different aspects of HIF regulation are well known, it is still unclear by which precise mechanism HIFs activate transcription of their target genes. Concomitantly, hypoxia provokes a dramatic decrease of general transcription that seems to rely in part on epigenetic changes through a poorly understood mechanism. In this review we discuss the current knowledge on chromatin changes involved in HIF dependent gene activation, as well as on other epigenetic changes, not necessarily linked to HIF that take place under hypoxic conditions. © 2011 by the authors. |
| author |
Acevedo, Julieta María Wappner, Pablo |
| author_facet |
Acevedo, Julieta María Wappner, Pablo |
| author_sort |
Acevedo, Julieta María |
| title |
Epigenetics: New questions on the response to hypoxia |
| title_short |
Epigenetics: New questions on the response to hypoxia |
| title_full |
Epigenetics: New questions on the response to hypoxia |
| title_fullStr |
Epigenetics: New questions on the response to hypoxia |
| title_full_unstemmed |
Epigenetics: New questions on the response to hypoxia |
| title_sort |
epigenetics: new questions on the response to hypoxia |
| publishDate |
2011 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14220067_v12_n7_p4705_PerezPerri http://hdl.handle.net/20.500.12110/paper_14220067_v12_n7_p4705_PerezPerri |
| work_keys_str_mv |
AT acevedojulietamaria epigeneticsnewquestionsontheresponsetohypoxia AT wappnerpablo epigeneticsnewquestionsontheresponsetohypoxia |
| _version_ |
1768542520876204032 |