Synaptic control of local translation: the plot thickens with new characters

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The production of proteins from mRNAs localized at the synapse ultimately controls the strength of synaptic transmission, thereby affecting behavior and cognitive functions. The regulated transcription, processing, and transport of mRNAs provide dynamic control of the dendritic transcriptome, which...

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Autores principales: Thomas, María Gabriela, Maschi, Darío, Luchelli, Luciana, Boccaccio, Graciela Lidia
Publicado: 2013
Materias:
Abnormal protein aggregation
ARC/Arg3.1
EJC
mTOR
NMDAR
Stress granules
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1420682X_v_n_p1_Thomas
http://hdl.handle.net/20.500.12110/paper_1420682X_v_n_p1_Thomas
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_1420682X_v_n_p1_Thomas
record_format dspace
spelling paper:paper_1420682X_v_n_p1_Thomas2023-06-08T16:13:47Z Synaptic control of local translation: the plot thickens with new characters Thomas, María Gabriela Maschi, Darío Luchelli, Luciana Boccaccio, Graciela Lidia Abnormal protein aggregation ARC/Arg3.1 EJC mTOR NMDAR Stress granules The production of proteins from mRNAs localized at the synapse ultimately controls the strength of synaptic transmission, thereby affecting behavior and cognitive functions. The regulated transcription, processing, and transport of mRNAs provide dynamic control of the dendritic transcriptome, which includes thousands of messengers encoding multiple cellular functions. Translation is locally modulated by synaptic activity through a complex network of RNA-binding proteins (RBPs) and various types of non-coding RNAs (ncRNAs) including BC-RNAs, microRNAs, piwi-interacting RNAs, and small interference RNAs. The RBPs FMRP and CPEB play a well-established role in synaptic translation, and additional regulatory factors are emerging. The mRNA repressors Smaug, Nanos, and Pumilio define a novel pathway for local translational control that affects dendritic branching and spines in both flies and mammals. Recent findings support a role for processing bodies and related synaptic mRNA-silencing foci (SyAS-foci) in the modulation of synaptic plasticity and memory formation. The SyAS-foci respond to different stimuli with changes in their integrity thus enabling regulated mRNA release followed by translation. CPEB, Pumilio, TDP-43, and FUS/TLS form multimers through low-complexity regions related to prion domains or polyQ expansions. The oligomerization of these repressor RBPs is mechanistically linked to the aggregation of abnormal proteins commonly associated with neurodegeneration. Here, we summarize the current knowledge on how specificity in mRNA translation is achieved through the concerted action of multiple pathways that involve regulatory ncRNAs and RBPs, the modification of translation factors, and mRNA-silencing foci dynamics. © 2013 Springer Basel. Fil:Thomas, M.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Maschi, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Luchelli, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Boccaccio, G.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1420682X_v_n_p1_Thomas http://hdl.handle.net/20.500.12110/paper_1420682X_v_n_p1_Thomas
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Abnormal protein aggregation
ARC/Arg3.1
EJC
mTOR
NMDAR
Stress granules
spellingShingle Abnormal protein aggregation
ARC/Arg3.1
EJC
mTOR
NMDAR
Stress granules
Thomas, María Gabriela
Maschi, Darío
Luchelli, Luciana
Boccaccio, Graciela Lidia
Synaptic control of local translation: the plot thickens with new characters
topic_facet Abnormal protein aggregation
ARC/Arg3.1
EJC
mTOR
NMDAR
Stress granules
description The production of proteins from mRNAs localized at the synapse ultimately controls the strength of synaptic transmission, thereby affecting behavior and cognitive functions. The regulated transcription, processing, and transport of mRNAs provide dynamic control of the dendritic transcriptome, which includes thousands of messengers encoding multiple cellular functions. Translation is locally modulated by synaptic activity through a complex network of RNA-binding proteins (RBPs) and various types of non-coding RNAs (ncRNAs) including BC-RNAs, microRNAs, piwi-interacting RNAs, and small interference RNAs. The RBPs FMRP and CPEB play a well-established role in synaptic translation, and additional regulatory factors are emerging. The mRNA repressors Smaug, Nanos, and Pumilio define a novel pathway for local translational control that affects dendritic branching and spines in both flies and mammals. Recent findings support a role for processing bodies and related synaptic mRNA-silencing foci (SyAS-foci) in the modulation of synaptic plasticity and memory formation. The SyAS-foci respond to different stimuli with changes in their integrity thus enabling regulated mRNA release followed by translation. CPEB, Pumilio, TDP-43, and FUS/TLS form multimers through low-complexity regions related to prion domains or polyQ expansions. The oligomerization of these repressor RBPs is mechanistically linked to the aggregation of abnormal proteins commonly associated with neurodegeneration. Here, we summarize the current knowledge on how specificity in mRNA translation is achieved through the concerted action of multiple pathways that involve regulatory ncRNAs and RBPs, the modification of translation factors, and mRNA-silencing foci dynamics. © 2013 Springer Basel.
author Thomas, María Gabriela
Maschi, Darío
Luchelli, Luciana
Boccaccio, Graciela Lidia
author_facet Thomas, María Gabriela
Maschi, Darío
Luchelli, Luciana
Boccaccio, Graciela Lidia
author_sort Thomas, María Gabriela
title Synaptic control of local translation: the plot thickens with new characters
title_short Synaptic control of local translation: the plot thickens with new characters
title_full Synaptic control of local translation: the plot thickens with new characters
title_fullStr Synaptic control of local translation: the plot thickens with new characters
title_full_unstemmed Synaptic control of local translation: the plot thickens with new characters
title_sort synaptic control of local translation: the plot thickens with new characters
publishDate 2013
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1420682X_v_n_p1_Thomas
http://hdl.handle.net/20.500.12110/paper_1420682X_v_n_p1_Thomas
work_keys_str_mv AT thomasmariagabriela synapticcontroloflocaltranslationtheplotthickenswithnewcharacters
AT maschidario synapticcontroloflocaltranslationtheplotthickenswithnewcharacters
AT luchelliluciana synapticcontroloflocaltranslationtheplotthickenswithnewcharacters
AT boccacciogracielalidia synapticcontroloflocaltranslationtheplotthickenswithnewcharacters
_version_ 1768545752356749312

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