Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study
Tinnitus, the phantom perception of sounds, is a highly prevalent disorder. Although a wide variety of drugs have been investigated off label for the treatment of tinnitus, there is no approved pharmacotherapy. We report an open-label exploratory pilot study to assess the effect of muscle relaxants...
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Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14203030_v17_n3_p179_Coelho http://hdl.handle.net/20.500.12110/paper_14203030_v17_n3_p179_Coelho |
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paper:paper_14203030_v17_n3_p179_Coelho2023-06-08T16:13:33Z Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study Muscle relaxants Phantom perception Somatosensory system Tinnitus amitriptyline central muscle relaxant clonidine cyclobenzaprine drug derivative eperisone orphenadrine propiophenone derivative tizanidine adult aged article clinical trial female hospitalization human male middle aged pilot study tinnitus treatment outcome Adult Aged Amitriptyline Clonidine Female Humans Male Middle Aged Muscle Relaxants, Central Orphenadrine Pilot Projects Propiophenones Severity of Illness Index Tinnitus Treatment Outcome Tinnitus, the phantom perception of sounds, is a highly prevalent disorder. Although a wide variety of drugs have been investigated off label for the treatment of tinnitus, there is no approved pharmacotherapy. We report an open-label exploratory pilot study to assess the effect of muscle relaxants acting on the central nervous system on tinnitus patients. Cyclobenzaprine at high (30 mg) and low doses (10 mg), orphenadrine (100 mg), tizanidine (24 mg) and eperisone (50 mg) were administered to a maximum of 20 patients per group over a 12-week period. High-dose cyclobenzaprine resulted in a significant reduction in the Tinnitus Handicap Inventory (THI) score between baseline and week 12 in the intention-to-treat sample. On the other hand, other treatments were not effective. These results were confirmed in an explorative analysis where baseline corrected THI and Clinical Global Impression scores at week 12 were compared between groups. The present open trial presents a new promising pharmacotherapy for tinnitus that should be validated in placebo-controlled double-blind trials. Copyright © 2012 S. Karger AG, Basel. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14203030_v17_n3_p179_Coelho http://hdl.handle.net/20.500.12110/paper_14203030_v17_n3_p179_Coelho |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Muscle relaxants Phantom perception Somatosensory system Tinnitus amitriptyline central muscle relaxant clonidine cyclobenzaprine drug derivative eperisone orphenadrine propiophenone derivative tizanidine adult aged article clinical trial female hospitalization human male middle aged pilot study tinnitus treatment outcome Adult Aged Amitriptyline Clonidine Female Humans Male Middle Aged Muscle Relaxants, Central Orphenadrine Pilot Projects Propiophenones Severity of Illness Index Tinnitus Treatment Outcome |
spellingShingle |
Muscle relaxants Phantom perception Somatosensory system Tinnitus amitriptyline central muscle relaxant clonidine cyclobenzaprine drug derivative eperisone orphenadrine propiophenone derivative tizanidine adult aged article clinical trial female hospitalization human male middle aged pilot study tinnitus treatment outcome Adult Aged Amitriptyline Clonidine Female Humans Male Middle Aged Muscle Relaxants, Central Orphenadrine Pilot Projects Propiophenones Severity of Illness Index Tinnitus Treatment Outcome Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study |
topic_facet |
Muscle relaxants Phantom perception Somatosensory system Tinnitus amitriptyline central muscle relaxant clonidine cyclobenzaprine drug derivative eperisone orphenadrine propiophenone derivative tizanidine adult aged article clinical trial female hospitalization human male middle aged pilot study tinnitus treatment outcome Adult Aged Amitriptyline Clonidine Female Humans Male Middle Aged Muscle Relaxants, Central Orphenadrine Pilot Projects Propiophenones Severity of Illness Index Tinnitus Treatment Outcome |
description |
Tinnitus, the phantom perception of sounds, is a highly prevalent disorder. Although a wide variety of drugs have been investigated off label for the treatment of tinnitus, there is no approved pharmacotherapy. We report an open-label exploratory pilot study to assess the effect of muscle relaxants acting on the central nervous system on tinnitus patients. Cyclobenzaprine at high (30 mg) and low doses (10 mg), orphenadrine (100 mg), tizanidine (24 mg) and eperisone (50 mg) were administered to a maximum of 20 patients per group over a 12-week period. High-dose cyclobenzaprine resulted in a significant reduction in the Tinnitus Handicap Inventory (THI) score between baseline and week 12 in the intention-to-treat sample. On the other hand, other treatments were not effective. These results were confirmed in an explorative analysis where baseline corrected THI and Clinical Global Impression scores at week 12 were compared between groups. The present open trial presents a new promising pharmacotherapy for tinnitus that should be validated in placebo-controlled double-blind trials. Copyright © 2012 S. Karger AG, Basel. |
title |
Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study |
title_short |
Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study |
title_full |
Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study |
title_fullStr |
Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study |
title_full_unstemmed |
Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: An open-label pilot study |
title_sort |
reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: an open-label pilot study |
publishDate |
2012 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14203030_v17_n3_p179_Coelho http://hdl.handle.net/20.500.12110/paper_14203030_v17_n3_p179_Coelho |
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1768544610655666176 |