The bone marrow micronucleus test and metronidazole genotoxicity in different strains of mice (Mus musculus)

The mouse (Mus musculus) bone marrow micronucleus test was carried out using 24 outbred National Institutes of Health (NIH) mice, 24 inbred Swiss Webster (CFW) mice and 20 inbred Bagg albino/color locus Jackson (BALB/cJ) mice. The mice in the experimental group (n=32) were injected intraperitoneally...

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Detalles Bibliográficos
Publicado: 2007
Materias:
BALB/cJ
Bone marrow micronucleus test
CFW
Genotoxicity
Metronidazole
NIH
metronidazole
animal experiment
animal model
animal tissue
article
Bagg albino mouse
bone marrow
controlled study
drug exposure
female
genetic toxicology
genotoxicity
inbred strain
male
micronucleus test
mouse
mouse strain
nonhuman
outbred strain
sex difference
statistical significance
strain difference
Swiss Webster mouse
toxicity testing
Mus
Mus musculus
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14154757_v30_n4_p1139_Abrevaya
http://hdl.handle.net/20.500.12110/paper_14154757_v30_n4_p1139_Abrevaya
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_14154757_v30_n4_p1139_Abrevaya
record_format dspace
spelling paper:paper_14154757_v30_n4_p1139_Abrevaya2023-06-08T16:13:29Z The bone marrow micronucleus test and metronidazole genotoxicity in different strains of mice (Mus musculus) BALB/cJ Bone marrow micronucleus test CFW Genotoxicity Metronidazole NIH metronidazole animal experiment animal model animal tissue article Bagg albino mouse bone marrow controlled study drug exposure female genetic toxicology genotoxicity inbred strain male micronucleus test mouse mouse strain nonhuman outbred strain sex difference statistical significance strain difference Swiss Webster mouse toxicity testing Mus Mus musculus The mouse (Mus musculus) bone marrow micronucleus test was carried out using 24 outbred National Institutes of Health (NIH) mice, 24 inbred Swiss Webster (CFW) mice and 20 inbred Bagg albino/color locus Jackson (BALB/cJ) mice. The mice in the experimental group (n=32) were injected intraperitoneally with 133 mg kg-1 of metronidazole parenteral solution and the control group consisted of mice (n=36) which had not been injected with metronidazole. There was no significant difference (p > 0.05) between the sexes regarding the micronucleus frequency in either the experimental or the control group. When the Mn frequencies of the three strains were compared, the results for the CFW and BALB/cJ strains did not differ statistically (p > 0.05) for either the experimental or control groups but there were significant (p < 0.05) differences between the CFW and NIH strains and the NIH and BALB/cJ strains for the experimental and control groups, with the NIH strain always showing the highest micronucleus frequency. Our results also show that metronidazole was possible genotoxic agent because it produced a significant increase (p < 0.05) in the micronucleus frequency of the experimental group as compared to the control group for all the three mouse strains tested. Copyright by the Brazilian Society of Genetics. 2007 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14154757_v30_n4_p1139_Abrevaya http://hdl.handle.net/20.500.12110/paper_14154757_v30_n4_p1139_Abrevaya
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic BALB/cJ
Bone marrow micronucleus test
CFW
Genotoxicity
Metronidazole
NIH
metronidazole
animal experiment
animal model
animal tissue
article
Bagg albino mouse
bone marrow
controlled study
drug exposure
female
genetic toxicology
genotoxicity
inbred strain
male
micronucleus test
mouse
mouse strain
nonhuman
outbred strain
sex difference
statistical significance
strain difference
Swiss Webster mouse
toxicity testing
Mus
Mus musculus
spellingShingle BALB/cJ
Bone marrow micronucleus test
CFW
Genotoxicity
Metronidazole
NIH
metronidazole
animal experiment
animal model
animal tissue
article
Bagg albino mouse
bone marrow
controlled study
drug exposure
female
genetic toxicology
genotoxicity
inbred strain
male
micronucleus test
mouse
mouse strain
nonhuman
outbred strain
sex difference
statistical significance
strain difference
Swiss Webster mouse
toxicity testing
Mus
Mus musculus
The bone marrow micronucleus test and metronidazole genotoxicity in different strains of mice (Mus musculus)
topic_facet BALB/cJ
Bone marrow micronucleus test
CFW
Genotoxicity
Metronidazole
NIH
metronidazole
animal experiment
animal model
animal tissue
article
Bagg albino mouse
bone marrow
controlled study
drug exposure
female
genetic toxicology
genotoxicity
inbred strain
male
micronucleus test
mouse
mouse strain
nonhuman
outbred strain
sex difference
statistical significance
strain difference
Swiss Webster mouse
toxicity testing
Mus
Mus musculus
description The mouse (Mus musculus) bone marrow micronucleus test was carried out using 24 outbred National Institutes of Health (NIH) mice, 24 inbred Swiss Webster (CFW) mice and 20 inbred Bagg albino/color locus Jackson (BALB/cJ) mice. The mice in the experimental group (n=32) were injected intraperitoneally with 133 mg kg-1 of metronidazole parenteral solution and the control group consisted of mice (n=36) which had not been injected with metronidazole. There was no significant difference (p > 0.05) between the sexes regarding the micronucleus frequency in either the experimental or the control group. When the Mn frequencies of the three strains were compared, the results for the CFW and BALB/cJ strains did not differ statistically (p > 0.05) for either the experimental or control groups but there were significant (p < 0.05) differences between the CFW and NIH strains and the NIH and BALB/cJ strains for the experimental and control groups, with the NIH strain always showing the highest micronucleus frequency. Our results also show that metronidazole was possible genotoxic agent because it produced a significant increase (p < 0.05) in the micronucleus frequency of the experimental group as compared to the control group for all the three mouse strains tested. Copyright by the Brazilian Society of Genetics.
title The bone marrow micronucleus test and metronidazole genotoxicity in different strains of mice (Mus musculus)
title_short The bone marrow micronucleus test and metronidazole genotoxicity in different strains of mice (Mus musculus)
title_full The bone marrow micronucleus test and metronidazole genotoxicity in different strains of mice (Mus musculus)
title_fullStr The bone marrow micronucleus test and metronidazole genotoxicity in different strains of mice (Mus musculus)
title_full_unstemmed The bone marrow micronucleus test and metronidazole genotoxicity in different strains of mice (Mus musculus)
title_sort bone marrow micronucleus test and metronidazole genotoxicity in different strains of mice (mus musculus)
publishDate 2007
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14154757_v30_n4_p1139_Abrevaya
http://hdl.handle.net/20.500.12110/paper_14154757_v30_n4_p1139_Abrevaya
_version_ 1768546601244033024

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