Elevated extension of longevity by cyclically heat stressing a set of recombinant inbred lines of Drosophila melanogaster throughout their adult life
An extremely high (about 100 %) increase in longevity is reported for a subset of recombinant inbred lines (RILs) of Drosophila melanogaster subjected to a cyclic heat stress throughout the adult life. Previous work showed that both longevity and heat sensitivity highly differed among RILs. The nove...
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2016
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13895729_v17_n5-6_p883_Gomez http://hdl.handle.net/20.500.12110/paper_13895729_v17_n5-6_p883_Gomez |
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paper:paper_13895729_v17_n5-6_p883_Gomez2023-06-08T16:13:11Z Elevated extension of longevity by cyclically heat stressing a set of recombinant inbred lines of Drosophila melanogaster throughout their adult life Gomez, Federico Hernan Sambucetti, Pablo Daniel Norry, Fabian Marcelo Heat-shock stress Hormesis Lifespan Quantitative trait locus (QTL) adult Article chromosome 2 controlled study Drosophila melanogaster female genotype heat stress heat treatment hormesis life extension lifespan longevity male nonhuman priority journal quantitative trait locus recombinant inbred strain sex difference aging animal Drosophila melanogaster gene expression regulation genetic recombination genetics heat shock response heat tolerance inbred strain longevity sexual development Drosophila protein Aging Animals Animals, Inbred Strains Drosophila melanogaster Drosophila Proteins Female Gene Expression Regulation, Developmental Heat-Shock Response Hormesis Longevity Male Quantitative Trait Loci Recombination, Genetic Sex Characteristics Thermotolerance An extremely high (about 100 %) increase in longevity is reported for a subset of recombinant inbred lines (RILs) of Drosophila melanogaster subjected to a cyclic heat stress throughout the adult life. Previous work showed that both longevity and heat sensitivity highly differed among RILs. The novel heat stress treatment used in this study consisted of 5 min at 38 °C applicated approximately every 125 min throughout the adult life starting at the age of 2 days. In spite of the exceptionally high increase in longevity in a set of RILs, the same heat stress treatment reduced rather than increased longevity in other RILs, suggesting that heat-induced hormesis is dependent on the genotype and/or the genetic background. Further, one quantitative trait locus (QTL) was identified for heat-induced hormesis on chromosome 2 (bands 28A1-34D2) in one RIL panel (RIL-D48) but it was not significant in its reciprocal panel (RIL-SH2). The level of heat-induced hormesis showed a sexual dimorphism, with a higher number of lines exhibiting higher hormesis effects in males than in females. The new heat stress treatment in this study suggests that longevity can be further extended than previously suggested by applying a cyclic and mild stress throughout the life, depending on the genotype. © 2016, Springer Science+Business Media Dordrecht. Fil:Gomez, F.H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Sambucetti, P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Norry, F.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13895729_v17_n5-6_p883_Gomez http://hdl.handle.net/20.500.12110/paper_13895729_v17_n5-6_p883_Gomez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Heat-shock stress Hormesis Lifespan Quantitative trait locus (QTL) adult Article chromosome 2 controlled study Drosophila melanogaster female genotype heat stress heat treatment hormesis life extension lifespan longevity male nonhuman priority journal quantitative trait locus recombinant inbred strain sex difference aging animal Drosophila melanogaster gene expression regulation genetic recombination genetics heat shock response heat tolerance inbred strain longevity sexual development Drosophila protein Aging Animals Animals, Inbred Strains Drosophila melanogaster Drosophila Proteins Female Gene Expression Regulation, Developmental Heat-Shock Response Hormesis Longevity Male Quantitative Trait Loci Recombination, Genetic Sex Characteristics Thermotolerance |
| spellingShingle |
Heat-shock stress Hormesis Lifespan Quantitative trait locus (QTL) adult Article chromosome 2 controlled study Drosophila melanogaster female genotype heat stress heat treatment hormesis life extension lifespan longevity male nonhuman priority journal quantitative trait locus recombinant inbred strain sex difference aging animal Drosophila melanogaster gene expression regulation genetic recombination genetics heat shock response heat tolerance inbred strain longevity sexual development Drosophila protein Aging Animals Animals, Inbred Strains Drosophila melanogaster Drosophila Proteins Female Gene Expression Regulation, Developmental Heat-Shock Response Hormesis Longevity Male Quantitative Trait Loci Recombination, Genetic Sex Characteristics Thermotolerance Gomez, Federico Hernan Sambucetti, Pablo Daniel Norry, Fabian Marcelo Elevated extension of longevity by cyclically heat stressing a set of recombinant inbred lines of Drosophila melanogaster throughout their adult life |
| topic_facet |
Heat-shock stress Hormesis Lifespan Quantitative trait locus (QTL) adult Article chromosome 2 controlled study Drosophila melanogaster female genotype heat stress heat treatment hormesis life extension lifespan longevity male nonhuman priority journal quantitative trait locus recombinant inbred strain sex difference aging animal Drosophila melanogaster gene expression regulation genetic recombination genetics heat shock response heat tolerance inbred strain longevity sexual development Drosophila protein Aging Animals Animals, Inbred Strains Drosophila melanogaster Drosophila Proteins Female Gene Expression Regulation, Developmental Heat-Shock Response Hormesis Longevity Male Quantitative Trait Loci Recombination, Genetic Sex Characteristics Thermotolerance |
| description |
An extremely high (about 100 %) increase in longevity is reported for a subset of recombinant inbred lines (RILs) of Drosophila melanogaster subjected to a cyclic heat stress throughout the adult life. Previous work showed that both longevity and heat sensitivity highly differed among RILs. The novel heat stress treatment used in this study consisted of 5 min at 38 °C applicated approximately every 125 min throughout the adult life starting at the age of 2 days. In spite of the exceptionally high increase in longevity in a set of RILs, the same heat stress treatment reduced rather than increased longevity in other RILs, suggesting that heat-induced hormesis is dependent on the genotype and/or the genetic background. Further, one quantitative trait locus (QTL) was identified for heat-induced hormesis on chromosome 2 (bands 28A1-34D2) in one RIL panel (RIL-D48) but it was not significant in its reciprocal panel (RIL-SH2). The level of heat-induced hormesis showed a sexual dimorphism, with a higher number of lines exhibiting higher hormesis effects in males than in females. The new heat stress treatment in this study suggests that longevity can be further extended than previously suggested by applying a cyclic and mild stress throughout the life, depending on the genotype. © 2016, Springer Science+Business Media Dordrecht. |
| author |
Gomez, Federico Hernan Sambucetti, Pablo Daniel Norry, Fabian Marcelo |
| author_facet |
Gomez, Federico Hernan Sambucetti, Pablo Daniel Norry, Fabian Marcelo |
| author_sort |
Gomez, Federico Hernan |
| title |
Elevated extension of longevity by cyclically heat stressing a set of recombinant inbred lines of Drosophila melanogaster throughout their adult life |
| title_short |
Elevated extension of longevity by cyclically heat stressing a set of recombinant inbred lines of Drosophila melanogaster throughout their adult life |
| title_full |
Elevated extension of longevity by cyclically heat stressing a set of recombinant inbred lines of Drosophila melanogaster throughout their adult life |
| title_fullStr |
Elevated extension of longevity by cyclically heat stressing a set of recombinant inbred lines of Drosophila melanogaster throughout their adult life |
| title_full_unstemmed |
Elevated extension of longevity by cyclically heat stressing a set of recombinant inbred lines of Drosophila melanogaster throughout their adult life |
| title_sort |
elevated extension of longevity by cyclically heat stressing a set of recombinant inbred lines of drosophila melanogaster throughout their adult life |
| publishDate |
2016 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13895729_v17_n5-6_p883_Gomez http://hdl.handle.net/20.500.12110/paper_13895729_v17_n5-6_p883_Gomez |
| work_keys_str_mv |
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