Failure to Recover from Proactive Semantic Interference and Abnormal Limbic Connectivity in Asymptomatic, Middle-Aged Offspring of Patients with Late-Onset Alzheimer's Disease
Background: We have obtained previous evidence of limbic dysfunction in middle-Aged, asymptomatic offspring of lateonset Alzheimer's disease (LOAD) patients, and failure to recover from proactive semantic interference has been shown to be a sensitive cognitive test in other groups at risk for L...
Guardado en:
| Publicado: |
2017
|
|---|---|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13872877_v60_n3_p1183_Sanchez http://hdl.handle.net/20.500.12110/paper_13872877_v60_n3_p1183_Sanchez |
| Aporte de: |
| id |
paper:paper_13872877_v60_n3_p1183_Sanchez |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_13872877_v60_n3_p1183_Sanchez2023-06-08T16:12:55Z Failure to Recover from Proactive Semantic Interference and Abnormal Limbic Connectivity in Asymptomatic, Middle-Aged Offspring of Patients with Late-Onset Alzheimer's Disease Entorhinal cortex functional connectivity late-onset Alzheimer's disease limbic proactive semantic interference thalamus adult age Alzheimer disease anterior cingulate anterior temporal cortex Article asymptomatic disease Beck Depression Inventory brain disease brain function clinical article cognition cognition assessment cognitive function test cognitive reserve Cognitive Reserve Questionnaire controlled study convalescence cross-sectional study dorsolateral prefrontal cortex entorhinal cortex female functional connectivity functional magnetic resonance imaging functional neuroimaging high risk patient human image analysis image processing insula limbic system Loewenstein Acevedo Scales for Semantic Interference and Learning cognitive stress test male medial orbitofrontal cortex middle aged middle frontal gyrus Mini Mental State Examination neocortex posterior cingulate precuneus priority journal proactive semantic interference Rey auditory verbal learning test right hippocampus temporal cortex thalamus anterior nucleus trail making test adult child Alzheimer disease brain mapping cognition diagnostic imaging genetic predisposition genetics limbic system nerve tract neuropsychological test nuclear magnetic resonance imaging onset age pathophysiology prodromal symptom psychology semantics Adult Children Age of Onset Alzheimer Disease Brain Mapping Cognition Cross-Sectional Studies Female Genetic Predisposition to Disease Humans Limbic System Magnetic Resonance Imaging Male Middle Aged Neural Pathways Neuropsychological Tests Prodromal Symptoms Semantics Background: We have obtained previous evidence of limbic dysfunction in middle-Aged, asymptomatic offspring of lateonset Alzheimer's disease (LOAD) patients, and failure to recover from proactive semantic interference has been shown to be a sensitive cognitive test in other groups at risk for LOAD. Objective: To assess the effects of specific proactive semantic interference deficits as they relate to functional magnetic resonance imaging (fMRI) neocortical and limbic functional connectivity in middle aged offspring of individuals with LOAD (O-LOAD) and age-equivalent controls. Methods:We examined 21O-LOADand 20 controls without family history of neurodegenerative disorders (CS) on traditional measures of cognitive functioning and the LASSI-L, a novel semantic interference test uniquely sensitive to the failure to recover from proactive interference (frPSI). Cognitive tests then were correlated to fMRI connectivity of seeds located in entorhinal cortex and anterodorsal thalamic nuclei among O-LOAD and CS participants. Results: Relative to CS, O-LOAD participants evidenced lower connectivity between entorhinal cortex and orbitofrontal, anterior cingulate, and anterior temporal cortex. In the offspring of LOAD patients, LASSI-L measures of frPSI were inversely associated with connectivity between anterodorsal thalamus and contralateral posterior cingulate. Intrusions on the task related to frPSI were inversely correlated with a widespread connectivity network involving hippocampal, insular, posterior cingulate, and dorsolateral prefrontal cortices, along with precunei and anterior thalamus in this group. Different patterns of connectivity associated with frPSI were observed among controls. Conclusion: The present results suggest that both semantic interference deficits and connectivity abnormalities might reflect limbic circuit dysfunction as a very early clinical signature of LOAD pathology, as previously demonstrated for other limbic phenotypes, such as sleep and circadian alterations. 2017 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13872877_v60_n3_p1183_Sanchez http://hdl.handle.net/20.500.12110/paper_13872877_v60_n3_p1183_Sanchez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Entorhinal cortex functional connectivity late-onset Alzheimer's disease limbic proactive semantic interference thalamus adult age Alzheimer disease anterior cingulate anterior temporal cortex Article asymptomatic disease Beck Depression Inventory brain disease brain function clinical article cognition cognition assessment cognitive function test cognitive reserve Cognitive Reserve Questionnaire controlled study convalescence cross-sectional study dorsolateral prefrontal cortex entorhinal cortex female functional connectivity functional magnetic resonance imaging functional neuroimaging high risk patient human image analysis image processing insula limbic system Loewenstein Acevedo Scales for Semantic Interference and Learning cognitive stress test male medial orbitofrontal cortex middle aged middle frontal gyrus Mini Mental State Examination neocortex posterior cingulate precuneus priority journal proactive semantic interference Rey auditory verbal learning test right hippocampus temporal cortex thalamus anterior nucleus trail making test adult child Alzheimer disease brain mapping cognition diagnostic imaging genetic predisposition genetics limbic system nerve tract neuropsychological test nuclear magnetic resonance imaging onset age pathophysiology prodromal symptom psychology semantics Adult Children Age of Onset Alzheimer Disease Brain Mapping Cognition Cross-Sectional Studies Female Genetic Predisposition to Disease Humans Limbic System Magnetic Resonance Imaging Male Middle Aged Neural Pathways Neuropsychological Tests Prodromal Symptoms Semantics |
| spellingShingle |
Entorhinal cortex functional connectivity late-onset Alzheimer's disease limbic proactive semantic interference thalamus adult age Alzheimer disease anterior cingulate anterior temporal cortex Article asymptomatic disease Beck Depression Inventory brain disease brain function clinical article cognition cognition assessment cognitive function test cognitive reserve Cognitive Reserve Questionnaire controlled study convalescence cross-sectional study dorsolateral prefrontal cortex entorhinal cortex female functional connectivity functional magnetic resonance imaging functional neuroimaging high risk patient human image analysis image processing insula limbic system Loewenstein Acevedo Scales for Semantic Interference and Learning cognitive stress test male medial orbitofrontal cortex middle aged middle frontal gyrus Mini Mental State Examination neocortex posterior cingulate precuneus priority journal proactive semantic interference Rey auditory verbal learning test right hippocampus temporal cortex thalamus anterior nucleus trail making test adult child Alzheimer disease brain mapping cognition diagnostic imaging genetic predisposition genetics limbic system nerve tract neuropsychological test nuclear magnetic resonance imaging onset age pathophysiology prodromal symptom psychology semantics Adult Children Age of Onset Alzheimer Disease Brain Mapping Cognition Cross-Sectional Studies Female Genetic Predisposition to Disease Humans Limbic System Magnetic Resonance Imaging Male Middle Aged Neural Pathways Neuropsychological Tests Prodromal Symptoms Semantics Failure to Recover from Proactive Semantic Interference and Abnormal Limbic Connectivity in Asymptomatic, Middle-Aged Offspring of Patients with Late-Onset Alzheimer's Disease |
| topic_facet |
Entorhinal cortex functional connectivity late-onset Alzheimer's disease limbic proactive semantic interference thalamus adult age Alzheimer disease anterior cingulate anterior temporal cortex Article asymptomatic disease Beck Depression Inventory brain disease brain function clinical article cognition cognition assessment cognitive function test cognitive reserve Cognitive Reserve Questionnaire controlled study convalescence cross-sectional study dorsolateral prefrontal cortex entorhinal cortex female functional connectivity functional magnetic resonance imaging functional neuroimaging high risk patient human image analysis image processing insula limbic system Loewenstein Acevedo Scales for Semantic Interference and Learning cognitive stress test male medial orbitofrontal cortex middle aged middle frontal gyrus Mini Mental State Examination neocortex posterior cingulate precuneus priority journal proactive semantic interference Rey auditory verbal learning test right hippocampus temporal cortex thalamus anterior nucleus trail making test adult child Alzheimer disease brain mapping cognition diagnostic imaging genetic predisposition genetics limbic system nerve tract neuropsychological test nuclear magnetic resonance imaging onset age pathophysiology prodromal symptom psychology semantics Adult Children Age of Onset Alzheimer Disease Brain Mapping Cognition Cross-Sectional Studies Female Genetic Predisposition to Disease Humans Limbic System Magnetic Resonance Imaging Male Middle Aged Neural Pathways Neuropsychological Tests Prodromal Symptoms Semantics |
| description |
Background: We have obtained previous evidence of limbic dysfunction in middle-Aged, asymptomatic offspring of lateonset Alzheimer's disease (LOAD) patients, and failure to recover from proactive semantic interference has been shown to be a sensitive cognitive test in other groups at risk for LOAD. Objective: To assess the effects of specific proactive semantic interference deficits as they relate to functional magnetic resonance imaging (fMRI) neocortical and limbic functional connectivity in middle aged offspring of individuals with LOAD (O-LOAD) and age-equivalent controls. Methods:We examined 21O-LOADand 20 controls without family history of neurodegenerative disorders (CS) on traditional measures of cognitive functioning and the LASSI-L, a novel semantic interference test uniquely sensitive to the failure to recover from proactive interference (frPSI). Cognitive tests then were correlated to fMRI connectivity of seeds located in entorhinal cortex and anterodorsal thalamic nuclei among O-LOAD and CS participants. Results: Relative to CS, O-LOAD participants evidenced lower connectivity between entorhinal cortex and orbitofrontal, anterior cingulate, and anterior temporal cortex. In the offspring of LOAD patients, LASSI-L measures of frPSI were inversely associated with connectivity between anterodorsal thalamus and contralateral posterior cingulate. Intrusions on the task related to frPSI were inversely correlated with a widespread connectivity network involving hippocampal, insular, posterior cingulate, and dorsolateral prefrontal cortices, along with precunei and anterior thalamus in this group. Different patterns of connectivity associated with frPSI were observed among controls. Conclusion: The present results suggest that both semantic interference deficits and connectivity abnormalities might reflect limbic circuit dysfunction as a very early clinical signature of LOAD pathology, as previously demonstrated for other limbic phenotypes, such as sleep and circadian alterations. |
| title |
Failure to Recover from Proactive Semantic Interference and Abnormal Limbic Connectivity in Asymptomatic, Middle-Aged Offspring of Patients with Late-Onset Alzheimer's Disease |
| title_short |
Failure to Recover from Proactive Semantic Interference and Abnormal Limbic Connectivity in Asymptomatic, Middle-Aged Offspring of Patients with Late-Onset Alzheimer's Disease |
| title_full |
Failure to Recover from Proactive Semantic Interference and Abnormal Limbic Connectivity in Asymptomatic, Middle-Aged Offspring of Patients with Late-Onset Alzheimer's Disease |
| title_fullStr |
Failure to Recover from Proactive Semantic Interference and Abnormal Limbic Connectivity in Asymptomatic, Middle-Aged Offspring of Patients with Late-Onset Alzheimer's Disease |
| title_full_unstemmed |
Failure to Recover from Proactive Semantic Interference and Abnormal Limbic Connectivity in Asymptomatic, Middle-Aged Offspring of Patients with Late-Onset Alzheimer's Disease |
| title_sort |
failure to recover from proactive semantic interference and abnormal limbic connectivity in asymptomatic, middle-aged offspring of patients with late-onset alzheimer's disease |
| publishDate |
2017 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13872877_v60_n3_p1183_Sanchez http://hdl.handle.net/20.500.12110/paper_13872877_v60_n3_p1183_Sanchez |
| _version_ |
1768541719417061376 |