Synthesis of galacturonate containing disaccharides and protein conjugates

The synthesis of galacturonate disaccharides has been performed from suitable protected monosaccharides. The use of orthogonal protecting groups allowed us to obtain both methyl galacturonates and galacturonic acid precursors as glycosylation donors or acceptors from a unique monosaccharide derivati...

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Autores principales: Landoni, Malena, Couto, Alicia Susana, Kovensky, José Eduardo
Publicado: 2011
Materias:
Conjugates
Galacturonate
Glycosylation
MALDI-MS
Synthesis
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13852728_v15_n19_p3523_Pourcelot
http://hdl.handle.net/20.500.12110/paper_13852728_v15_n19_p3523_Pourcelot
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_13852728_v15_n19_p3523_Pourcelot
record_format dspace
spelling paper:paper_13852728_v15_n19_p3523_Pourcelot2023-06-08T16:12:43Z Synthesis of galacturonate containing disaccharides and protein conjugates Landoni, Malena Couto, Alicia Susana Kovensky, José Eduardo Conjugates Galacturonate Glycosylation MALDI-MS Synthesis The synthesis of galacturonate disaccharides has been performed from suitable protected monosaccharides. The use of orthogonal protecting groups allowed us to obtain both methyl galacturonates and galacturonic acid precursors as glycosylation donors or acceptors from a unique monosaccharide derivative. The protecting groups used allowed selective introduction of a fatty acid chain to the non-reducing end of a disaccharide. Furthermore, we explored the preparation of galacturonate conjugated to a carrier protein, and determined the number of sugar residues coupled to the protein by MALDI-MS. © 2011 Bentham Science Publishers. Fil:Landoni, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Couto, A.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kovensky, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13852728_v15_n19_p3523_Pourcelot http://hdl.handle.net/20.500.12110/paper_13852728_v15_n19_p3523_Pourcelot
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Conjugates
Galacturonate
Glycosylation
MALDI-MS
Synthesis
spellingShingle Conjugates
Galacturonate
Glycosylation
MALDI-MS
Synthesis
Landoni, Malena
Couto, Alicia Susana
Kovensky, José Eduardo
Synthesis of galacturonate containing disaccharides and protein conjugates
topic_facet Conjugates
Galacturonate
Glycosylation
MALDI-MS
Synthesis
description The synthesis of galacturonate disaccharides has been performed from suitable protected monosaccharides. The use of orthogonal protecting groups allowed us to obtain both methyl galacturonates and galacturonic acid precursors as glycosylation donors or acceptors from a unique monosaccharide derivative. The protecting groups used allowed selective introduction of a fatty acid chain to the non-reducing end of a disaccharide. Furthermore, we explored the preparation of galacturonate conjugated to a carrier protein, and determined the number of sugar residues coupled to the protein by MALDI-MS. © 2011 Bentham Science Publishers.
author Landoni, Malena
Couto, Alicia Susana
Kovensky, José Eduardo
author_facet Landoni, Malena
Couto, Alicia Susana
Kovensky, José Eduardo
author_sort Landoni, Malena
title Synthesis of galacturonate containing disaccharides and protein conjugates
title_short Synthesis of galacturonate containing disaccharides and protein conjugates
title_full Synthesis of galacturonate containing disaccharides and protein conjugates
title_fullStr Synthesis of galacturonate containing disaccharides and protein conjugates
title_full_unstemmed Synthesis of galacturonate containing disaccharides and protein conjugates
title_sort synthesis of galacturonate containing disaccharides and protein conjugates
publishDate 2011
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13852728_v15_n19_p3523_Pourcelot
http://hdl.handle.net/20.500.12110/paper_13852728_v15_n19_p3523_Pourcelot
work_keys_str_mv AT landonimalena synthesisofgalacturonatecontainingdisaccharidesandproteinconjugates
AT coutoaliciasusana synthesisofgalacturonatecontainingdisaccharidesandproteinconjugates
AT kovenskyjoseeduardo synthesisofgalacturonatecontainingdisaccharidesandproteinconjugates
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