Multicomponent synthesis of acylated short peptoids with antifungal activity against plant pathogens
In this article, we describe the synthesis of a small library of short peptoids composed of four glycine residues and acylated with a fatty acid that showed a remarkable in vitro activity against two fungal plant pathogens. Their straightforward synthesis implied two consecutive Ugi reactions and ca...
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2012
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13811991_v16_n1_p113_Galetti http://hdl.handle.net/20.500.12110/paper_13811991_v16_n1_p113_Galetti |
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paper:paper_13811991_v16_n1_p113_Galetti2023-06-08T16:12:23Z Multicomponent synthesis of acylated short peptoids with antifungal activity against plant pathogens Cirigliano, Adriana Mónica Cabrera, Gabriela Myriam Ramirez, Javier Alberto Acylated peptoids Antifungal Multicomponent reaction Plant pathogen glycine peptoid acylation antifungal activity article chemical reaction drug structure drug synthesis electrospray mass spectrometry minimum inhibitory concentration nonhuman plant disease priority journal ugi reaction Acylation Amines Antifungal Agents Fusarium Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Peptoids Plants Spectrometry, Mass, Electrospray Ionization In this article, we describe the synthesis of a small library of short peptoids composed of four glycine residues and acylated with a fatty acid that showed a remarkable in vitro activity against two fungal plant pathogens. Their straightforward synthesis implied two consecutive Ugi reactions and can be efficiently extended to the construction of highly diverse libraries. © 2011 Springer Science+Business Media B.V. Fil:Cirigliano, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cabrera, G.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ramírez, J.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13811991_v16_n1_p113_Galetti http://hdl.handle.net/20.500.12110/paper_13811991_v16_n1_p113_Galetti |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Acylated peptoids Antifungal Multicomponent reaction Plant pathogen glycine peptoid acylation antifungal activity article chemical reaction drug structure drug synthesis electrospray mass spectrometry minimum inhibitory concentration nonhuman plant disease priority journal ugi reaction Acylation Amines Antifungal Agents Fusarium Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Peptoids Plants Spectrometry, Mass, Electrospray Ionization |
| spellingShingle |
Acylated peptoids Antifungal Multicomponent reaction Plant pathogen glycine peptoid acylation antifungal activity article chemical reaction drug structure drug synthesis electrospray mass spectrometry minimum inhibitory concentration nonhuman plant disease priority journal ugi reaction Acylation Amines Antifungal Agents Fusarium Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Peptoids Plants Spectrometry, Mass, Electrospray Ionization Cirigliano, Adriana Mónica Cabrera, Gabriela Myriam Ramirez, Javier Alberto Multicomponent synthesis of acylated short peptoids with antifungal activity against plant pathogens |
| topic_facet |
Acylated peptoids Antifungal Multicomponent reaction Plant pathogen glycine peptoid acylation antifungal activity article chemical reaction drug structure drug synthesis electrospray mass spectrometry minimum inhibitory concentration nonhuman plant disease priority journal ugi reaction Acylation Amines Antifungal Agents Fusarium Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Peptoids Plants Spectrometry, Mass, Electrospray Ionization |
| description |
In this article, we describe the synthesis of a small library of short peptoids composed of four glycine residues and acylated with a fatty acid that showed a remarkable in vitro activity against two fungal plant pathogens. Their straightforward synthesis implied two consecutive Ugi reactions and can be efficiently extended to the construction of highly diverse libraries. © 2011 Springer Science+Business Media B.V. |
| author |
Cirigliano, Adriana Mónica Cabrera, Gabriela Myriam Ramirez, Javier Alberto |
| author_facet |
Cirigliano, Adriana Mónica Cabrera, Gabriela Myriam Ramirez, Javier Alberto |
| author_sort |
Cirigliano, Adriana Mónica |
| title |
Multicomponent synthesis of acylated short peptoids with antifungal activity against plant pathogens |
| title_short |
Multicomponent synthesis of acylated short peptoids with antifungal activity against plant pathogens |
| title_full |
Multicomponent synthesis of acylated short peptoids with antifungal activity against plant pathogens |
| title_fullStr |
Multicomponent synthesis of acylated short peptoids with antifungal activity against plant pathogens |
| title_full_unstemmed |
Multicomponent synthesis of acylated short peptoids with antifungal activity against plant pathogens |
| title_sort |
multicomponent synthesis of acylated short peptoids with antifungal activity against plant pathogens |
| publishDate |
2012 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13811991_v16_n1_p113_Galetti http://hdl.handle.net/20.500.12110/paper_13811991_v16_n1_p113_Galetti |
| work_keys_str_mv |
AT ciriglianoadrianamonica multicomponentsynthesisofacylatedshortpeptoidswithantifungalactivityagainstplantpathogens AT cabreragabrielamyriam multicomponentsynthesisofacylatedshortpeptoidswithantifungalactivityagainstplantpathogens AT ramirezjavieralberto multicomponentsynthesisofacylatedshortpeptoidswithantifungalactivityagainstplantpathogens |
| _version_ |
1768543960350851072 |