Observable effects of Ca2+ buffers on local Ca2+ signals
Calcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have pr...
Guardado en:
Autores principales: | , |
---|---|
Publicado: |
2010
|
Materias: | |
Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1364503X_v368_n1933_p5597_Solovey http://hdl.handle.net/20.500.12110/paper_1364503X_v368_n1933_p5597_Solovey |
Aporte de: |
id |
paper:paper_1364503X_v368_n1933_p5597_Solovey |
---|---|
record_format |
dspace |
spelling |
paper:paper_1364503X_v368_n1933_p5597_Solovey2023-06-08T16:11:40Z Observable effects of Ca2+ buffers on local Ca2+ signals Solovey, Guillermo Ponce Dawson, Silvina Buffers Puffs Sugars Transport properties Buffers High resolution Local signal Optical experiments Physiological process Puffs Calcium buffer calcium inositol 1,4,5 trisphosphate algorithm article biological model calcium signaling cell membrane channel gating chemistry computer simulation cytosol dose response endoplasmic reticulum kinetics metabolism physiology probability statistical model Algorithms Buffers Calcium Calcium Signaling Cell Membrane Computer Simulation Cytosol Dose-Response Relationship, Drug Endoplasmic Reticulum Inositol 1,4,5-Trisphosphate Ion Channel Gating Kinetics Models, Biological Models, Statistical Probability Calcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have provided new information on Ca2+ release from clustered IP3Rs. In the present paper, we use the model recently introduced by Solovey & Ponce Dawson to determine how the distribution of the number of IP3Rs that become open during a localized release event may change by the presence of Ca2+ buffers, substances that react with Ca2+, altering its concentration and transport properties. We then discuss how buffer properties could be extracted from the observation of local signals. © 2010 The Royal Society. Fil:Solovey, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Dawson, S.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2010 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1364503X_v368_n1933_p5597_Solovey http://hdl.handle.net/20.500.12110/paper_1364503X_v368_n1933_p5597_Solovey |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Buffers Puffs Sugars Transport properties Buffers High resolution Local signal Optical experiments Physiological process Puffs Calcium buffer calcium inositol 1,4,5 trisphosphate algorithm article biological model calcium signaling cell membrane channel gating chemistry computer simulation cytosol dose response endoplasmic reticulum kinetics metabolism physiology probability statistical model Algorithms Buffers Calcium Calcium Signaling Cell Membrane Computer Simulation Cytosol Dose-Response Relationship, Drug Endoplasmic Reticulum Inositol 1,4,5-Trisphosphate Ion Channel Gating Kinetics Models, Biological Models, Statistical Probability |
spellingShingle |
Buffers Puffs Sugars Transport properties Buffers High resolution Local signal Optical experiments Physiological process Puffs Calcium buffer calcium inositol 1,4,5 trisphosphate algorithm article biological model calcium signaling cell membrane channel gating chemistry computer simulation cytosol dose response endoplasmic reticulum kinetics metabolism physiology probability statistical model Algorithms Buffers Calcium Calcium Signaling Cell Membrane Computer Simulation Cytosol Dose-Response Relationship, Drug Endoplasmic Reticulum Inositol 1,4,5-Trisphosphate Ion Channel Gating Kinetics Models, Biological Models, Statistical Probability Solovey, Guillermo Ponce Dawson, Silvina Observable effects of Ca2+ buffers on local Ca2+ signals |
topic_facet |
Buffers Puffs Sugars Transport properties Buffers High resolution Local signal Optical experiments Physiological process Puffs Calcium buffer calcium inositol 1,4,5 trisphosphate algorithm article biological model calcium signaling cell membrane channel gating chemistry computer simulation cytosol dose response endoplasmic reticulum kinetics metabolism physiology probability statistical model Algorithms Buffers Calcium Calcium Signaling Cell Membrane Computer Simulation Cytosol Dose-Response Relationship, Drug Endoplasmic Reticulum Inositol 1,4,5-Trisphosphate Ion Channel Gating Kinetics Models, Biological Models, Statistical Probability |
description |
Calcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have provided new information on Ca2+ release from clustered IP3Rs. In the present paper, we use the model recently introduced by Solovey & Ponce Dawson to determine how the distribution of the number of IP3Rs that become open during a localized release event may change by the presence of Ca2+ buffers, substances that react with Ca2+, altering its concentration and transport properties. We then discuss how buffer properties could be extracted from the observation of local signals. © 2010 The Royal Society. |
author |
Solovey, Guillermo Ponce Dawson, Silvina |
author_facet |
Solovey, Guillermo Ponce Dawson, Silvina |
author_sort |
Solovey, Guillermo |
title |
Observable effects of Ca2+ buffers on local Ca2+ signals |
title_short |
Observable effects of Ca2+ buffers on local Ca2+ signals |
title_full |
Observable effects of Ca2+ buffers on local Ca2+ signals |
title_fullStr |
Observable effects of Ca2+ buffers on local Ca2+ signals |
title_full_unstemmed |
Observable effects of Ca2+ buffers on local Ca2+ signals |
title_sort |
observable effects of ca2+ buffers on local ca2+ signals |
publishDate |
2010 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1364503X_v368_n1933_p5597_Solovey http://hdl.handle.net/20.500.12110/paper_1364503X_v368_n1933_p5597_Solovey |
work_keys_str_mv |
AT soloveyguillermo observableeffectsofca2buffersonlocalca2signals AT poncedawsonsilvina observableeffectsofca2buffersonlocalca2signals |
_version_ |
1768545157689376768 |