Aluminium accumulation in chronic renal failure affects erythropoises

Aluminium (Al) toxicity has been associated with anaemia in exposed patients with chronic renal failure (CRF). The present study was undertaken to determine whether the ingestion of Al citrate was able to affect erythropoiesis in rats with normal or impaired renal function. The renal insufficiency w...

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Autores principales:	Nesse, Alcira Beatriz, Garbosa, Graciela, Stripeikis, Jorge Daniel, Gálvez, Gladys Alicia, Lauricella, Ana María
Publicado:	1997
Materias:	Aluminium and erythropoiesis Aluminum Aluminum toxicity Chronic renal failure aluminum citrate animal experiment animal model animal tissue article bone brain chronic kidney failure controlled study erythropoiesis kidney liver male nonhuman priority journal rat serum tissue distribution toxicity testing
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13205358_v3_n4_p347_Nesse http://hdl.handle.net/20.500.12110/paper_13205358_v3_n4_p347_Nesse
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_13205358_v3_n4_p347_Nesse
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spelling	paper:paper_13205358_v3_n4_p347_Nesse2023-06-08T16:10:22Z Aluminium accumulation in chronic renal failure affects erythropoises Nesse, Alcira Beatriz Garbosa, Graciela Stripeikis, Jorge Daniel Gálvez, Gladys Alicia Lauricella, Ana María Aluminium and erythropoiesis Aluminum Aluminum toxicity Chronic renal failure aluminum citrate animal experiment animal model animal tissue article bone brain chronic kidney failure controlled study erythropoiesis kidney liver male nonhuman priority journal rat serum tissue distribution toxicity testing Aluminium (Al) toxicity has been associated with anaemia in exposed patients with chronic renal failure (CRF). The present study was undertaken to determine whether the ingestion of Al citrate was able to affect erythropoiesis in rats with normal or impaired renal function. The renal insufficiency was induced by surgical procedures and control rats were sham operated. Twenty-four rats were allocated to four groups of six rats each: (A) Sham; (B) Sham+Al; (C) CRF; and (D) CRF+Al. The groups B and D received daily doses of Al citrate (0.5 μmol/g bodyweight) and the groups A and C, deionized water, via the intragastric route. At the end of the experimental period (15 weeks) cultures of late erythroid progenitor cells (CFU-E) stimulated with erythropoietin were performed and haematological parameters determined. The liver, kidney, brain, bone and serum Al amounts were quantified. The results are expressed as median and interquartile range. The CFU-E growth was found inhibited in B and D groups (A: 100; B: 74/54-83; C: 86/54-98; D: 46/39-53 %). The haematocrit values were significantly diminished in rats with renal insufficiency when compared to controls (A: 42/40-43; B: 45/42-46; C: 37/32-40 and D: 37/24-39 %). Serum Al accumulation was observed in B and D groups receiving Al (A: 8/5-12; B: 36/36-44; C: 5/5- 6; D: 45126-132 μg Al]l). No differences among groups were found in the liver and kidney Al contents, but uraemic state favoured Al accumulation in brain (A: 6/5.0-9.0; B: 4/3.8-4.3; C: 2/2.0-3.0; D: 15/12.0-21.0 μg Al/g tissue) and bone (A: 29/27-31; B: 30/29-39; C: 42/33-48; D: 68/56-79 μg Al/g tissue). We suggest that the heavy accumulation of Al in the bone compartment may result in a protracted endogenous exposure of bone marrow cells, affecting the erythropoiesis in vive. Fil:Nesse, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Garbossa, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Stripeikis, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gálvez, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Lauricella, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1997 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13205358_v3_n4_p347_Nesse http://hdl.handle.net/20.500.12110/paper_13205358_v3_n4_p347_Nesse
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Aluminium and erythropoiesis Aluminum Aluminum toxicity Chronic renal failure aluminum citrate animal experiment animal model animal tissue article bone brain chronic kidney failure controlled study erythropoiesis kidney liver male nonhuman priority journal rat serum tissue distribution toxicity testing
spellingShingle	Aluminium and erythropoiesis Aluminum Aluminum toxicity Chronic renal failure aluminum citrate animal experiment animal model animal tissue article bone brain chronic kidney failure controlled study erythropoiesis kidney liver male nonhuman priority journal rat serum tissue distribution toxicity testing Nesse, Alcira Beatriz Garbosa, Graciela Stripeikis, Jorge Daniel Gálvez, Gladys Alicia Lauricella, Ana María Aluminium accumulation in chronic renal failure affects erythropoises
topic_facet	Aluminium and erythropoiesis Aluminum Aluminum toxicity Chronic renal failure aluminum citrate animal experiment animal model animal tissue article bone brain chronic kidney failure controlled study erythropoiesis kidney liver male nonhuman priority journal rat serum tissue distribution toxicity testing
description	Aluminium (Al) toxicity has been associated with anaemia in exposed patients with chronic renal failure (CRF). The present study was undertaken to determine whether the ingestion of Al citrate was able to affect erythropoiesis in rats with normal or impaired renal function. The renal insufficiency was induced by surgical procedures and control rats were sham operated. Twenty-four rats were allocated to four groups of six rats each: (A) Sham; (B) Sham+Al; (C) CRF; and (D) CRF+Al. The groups B and D received daily doses of Al citrate (0.5 μmol/g bodyweight) and the groups A and C, deionized water, via the intragastric route. At the end of the experimental period (15 weeks) cultures of late erythroid progenitor cells (CFU-E) stimulated with erythropoietin were performed and haematological parameters determined. The liver, kidney, brain, bone and serum Al amounts were quantified. The results are expressed as median and interquartile range. The CFU-E growth was found inhibited in B and D groups (A: 100; B: 74/54-83; C: 86/54-98; D: 46/39-53 %). The haematocrit values were significantly diminished in rats with renal insufficiency when compared to controls (A: 42/40-43; B: 45/42-46; C: 37/32-40 and D: 37/24-39 %). Serum Al accumulation was observed in B and D groups receiving Al (A: 8/5-12; B: 36/36-44; C: 5/5- 6; D: 45126-132 μg Al]l). No differences among groups were found in the liver and kidney Al contents, but uraemic state favoured Al accumulation in brain (A: 6/5.0-9.0; B: 4/3.8-4.3; C: 2/2.0-3.0; D: 15/12.0-21.0 μg Al/g tissue) and bone (A: 29/27-31; B: 30/29-39; C: 42/33-48; D: 68/56-79 μg Al/g tissue). We suggest that the heavy accumulation of Al in the bone compartment may result in a protracted endogenous exposure of bone marrow cells, affecting the erythropoiesis in vive.
author	Nesse, Alcira Beatriz Garbosa, Graciela Stripeikis, Jorge Daniel Gálvez, Gladys Alicia Lauricella, Ana María
author_facet	Nesse, Alcira Beatriz Garbosa, Graciela Stripeikis, Jorge Daniel Gálvez, Gladys Alicia Lauricella, Ana María
author_sort	Nesse, Alcira Beatriz
title	Aluminium accumulation in chronic renal failure affects erythropoises
title_short	Aluminium accumulation in chronic renal failure affects erythropoises
title_full	Aluminium accumulation in chronic renal failure affects erythropoises
title_fullStr	Aluminium accumulation in chronic renal failure affects erythropoises
title_full_unstemmed	Aluminium accumulation in chronic renal failure affects erythropoises
title_sort	aluminium accumulation in chronic renal failure affects erythropoises
publishDate	1997
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13205358_v3_n4_p347_Nesse http://hdl.handle.net/20.500.12110/paper_13205358_v3_n4_p347_Nesse
work_keys_str_mv	AT nessealcirabeatriz aluminiumaccumulationinchronicrenalfailureaffectserythropoises AT garbosagraciela aluminiumaccumulationinchronicrenalfailureaffectserythropoises AT stripeikisjorgedaniel aluminiumaccumulationinchronicrenalfailureaffectserythropoises AT galvezgladysalicia aluminiumaccumulationinchronicrenalfailureaffectserythropoises AT lauricellaanamaria aluminiumaccumulationinchronicrenalfailureaffectserythropoises
_version_	1768544832650739712

Aluminium accumulation in chronic renal failure affects erythropoises

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