Nitric oxide sets off an antioxidant response in adrenal cells: Involvement of sGC and Nrf2 in HO-1 induction

Induction of microsomal heme oxygenase 1 (HO-1) activity is considered a cytoprotective mechanism in different cell types. In adrenal cells, HO-1 induction by ACTH exerts a modulatory effect on steroid production as well. As nitric oxide (NO) has been also regarded as an autocrine/paracrine modulato...

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Detalles Bibliográficos
Autores principales:	Astort, Francisco, Degese, Maria Sol, Coso, Omar Adrian, Cymeryng, Cora Beatriz
Publicado:	2014
Materias:	cGMP Heme oxygenase 1 Nitric oxide Nuclear factor-erythroid 2-related factor (Nrf2) Soluble guanylate cyclase cyclic GMP dactinomycin diethylenetriamine guanylate cyclase guanylate cyclase inhibitor heme oxygenase 1 messenger RNA nitric oxide transcription factor Nrf2 antioxidant Nfe2l2 protein, mouse adrenal cortex cell animal cell article cellular stress response controlled study enzyme induction intracellular signaling mouse nonhuman oxidative stress priority journal protein localization regulatory mechanism RNA degradation transcription initiation transient transfection adrenal gland animal cell culture cytology enzymology metabolism solubility Adrenal Glands Animals Antioxidants Cells, Cultured Guanylate Cyclase Heme Oxygenase-1 Mice NF-E2-Related Factor 2 Nitric Oxide Solubility
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10898603_v37_n1_p1_Astort http://hdl.handle.net/20.500.12110/paper_10898603_v37_n1_p1_Astort
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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