Pharmacokinetic and pharmacodynamic properties of enrofloxacin in Southern crested caracaras (Caracara plancus)

To determine the dosage of enrofloxacin in southern crested caracaras (Caracara plancus), plasma concentrations of enrofloxacin were measured by high-performance liquid chromatography after intravenous (IV) (5 mg/kg) and intramuscular (IM) (10 mg/kg) administration. This compound presented a relativ...

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Autor principal:	Orozco, Maria Marcela
Publicado:	2013
Materias:	Caracara plancus Enrofloxacin Fluoroquinolones pharmacokinetics Pharmacodynamics Southern creasted caracars antiinfective agent ciprofloxacin enrofloxacin quinolone derivative animal area under the curve article bird blood Campylobacter jejuni clinical trial drug effect Escherichia coli half life time metabolism microbial sensitivity test Animals Anti-Bacterial Agents Area Under Curve Birds Ciprofloxacin Fluoroquinolones Half-Life Microbial Sensitivity Tests
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10826742_v27_n3_p180_Waxman http://hdl.handle.net/20.500.12110/paper_10826742_v27_n3_p180_Waxman
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_10826742_v27_n3_p180_Waxman
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spelling	paper:paper_10826742_v27_n3_p180_Waxman2023-06-08T16:05:52Z Pharmacokinetic and pharmacodynamic properties of enrofloxacin in Southern crested caracaras (Caracara plancus) Orozco, Maria Marcela Caracara plancus Enrofloxacin Fluoroquinolones pharmacokinetics Pharmacodynamics Southern creasted caracars antiinfective agent ciprofloxacin enrofloxacin quinolone derivative animal area under the curve article bird blood Campylobacter jejuni clinical trial drug effect Escherichia coli half life time metabolism microbial sensitivity test Animals Anti-Bacterial Agents Area Under Curve Birds Campylobacter jejuni Ciprofloxacin Escherichia coli Fluoroquinolones Half-Life Microbial Sensitivity Tests To determine the dosage of enrofloxacin in southern crested caracaras (Caracara plancus), plasma concentrations of enrofloxacin were measured by high-performance liquid chromatography after intravenous (IV) (5 mg/kg) and intramuscular (IM) (10 mg/kg) administration. This compound presented a relatively high volume of distribution (2.09 L/kg), a total body clearance of 0.24 L/kg·h, and a long permanence as shown by an elimination half-life of 7.81 hours after IV administration and a terminal half-life of 6.58 hours after IM administration. The areas under the concentration-time curves (AUC) were 21.92 and 34.38 μg·h/mL for IM and IV administration, respectively. Enrofloxacin was rapidly absorbed after IM administration with a time to reach maximum concentration of 0.72 hours and bioavailability of 78.76%. After IM administration, the peak drug concentration (Cmax) was 3.92 μg/mL. Values of minimum inhibitory concentration (MIC), Cmax, and AUC have been used to predict the clinical efficacy of a drug in treating bacterial infections, with a Cmax/MIC value of 10 and an AUC/MIC ratio of 125-250 associated with optimal bactericidal effects. By using the study data and a MIC breakpoint of 0.25 μg/mL, values of Cmax/MIC were 13.74 and 15.94 and for AUC/MIC were 90.73 and 139.63, for the IV and IM routes respectively. For the treatment of infectious diseases caused by microorganisms with MIC ≤0.25 μg/mL, the calculated optimal dosages were 7.5 and 9.5 mg/kg q24h by the IV and IM routes, respectively. For less susceptible bacteria, a dose increase should be evaluated. To treat caracara by the IV route against microorganisms with MIC ≤0.25 μg/mL, the dose should be higher than the 5 mg/kg used in our study, but possible side effects derived from an increase in the IV dose and efficacy in sick birds should be assessed. © 2013 by the Association of Avian Veterinarians. Fil:Orozco, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10826742_v27_n3_p180_Waxman http://hdl.handle.net/20.500.12110/paper_10826742_v27_n3_p180_Waxman
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Caracara plancus Enrofloxacin Fluoroquinolones pharmacokinetics Pharmacodynamics Southern creasted caracars antiinfective agent ciprofloxacin enrofloxacin quinolone derivative animal area under the curve article bird blood Campylobacter jejuni clinical trial drug effect Escherichia coli half life time metabolism microbial sensitivity test Animals Anti-Bacterial Agents Area Under Curve Birds Campylobacter jejuni Ciprofloxacin Escherichia coli Fluoroquinolones Half-Life Microbial Sensitivity Tests
spellingShingle	Caracara plancus Enrofloxacin Fluoroquinolones pharmacokinetics Pharmacodynamics Southern creasted caracars antiinfective agent ciprofloxacin enrofloxacin quinolone derivative animal area under the curve article bird blood Campylobacter jejuni clinical trial drug effect Escherichia coli half life time metabolism microbial sensitivity test Animals Anti-Bacterial Agents Area Under Curve Birds Campylobacter jejuni Ciprofloxacin Escherichia coli Fluoroquinolones Half-Life Microbial Sensitivity Tests Orozco, Maria Marcela Pharmacokinetic and pharmacodynamic properties of enrofloxacin in Southern crested caracaras (Caracara plancus)
topic_facet	Caracara plancus Enrofloxacin Fluoroquinolones pharmacokinetics Pharmacodynamics Southern creasted caracars antiinfective agent ciprofloxacin enrofloxacin quinolone derivative animal area under the curve article bird blood Campylobacter jejuni clinical trial drug effect Escherichia coli half life time metabolism microbial sensitivity test Animals Anti-Bacterial Agents Area Under Curve Birds Campylobacter jejuni Ciprofloxacin Escherichia coli Fluoroquinolones Half-Life Microbial Sensitivity Tests
description	To determine the dosage of enrofloxacin in southern crested caracaras (Caracara plancus), plasma concentrations of enrofloxacin were measured by high-performance liquid chromatography after intravenous (IV) (5 mg/kg) and intramuscular (IM) (10 mg/kg) administration. This compound presented a relatively high volume of distribution (2.09 L/kg), a total body clearance of 0.24 L/kg·h, and a long permanence as shown by an elimination half-life of 7.81 hours after IV administration and a terminal half-life of 6.58 hours after IM administration. The areas under the concentration-time curves (AUC) were 21.92 and 34.38 μg·h/mL for IM and IV administration, respectively. Enrofloxacin was rapidly absorbed after IM administration with a time to reach maximum concentration of 0.72 hours and bioavailability of 78.76%. After IM administration, the peak drug concentration (Cmax) was 3.92 μg/mL. Values of minimum inhibitory concentration (MIC), Cmax, and AUC have been used to predict the clinical efficacy of a drug in treating bacterial infections, with a Cmax/MIC value of 10 and an AUC/MIC ratio of 125-250 associated with optimal bactericidal effects. By using the study data and a MIC breakpoint of 0.25 μg/mL, values of Cmax/MIC were 13.74 and 15.94 and for AUC/MIC were 90.73 and 139.63, for the IV and IM routes respectively. For the treatment of infectious diseases caused by microorganisms with MIC ≤0.25 μg/mL, the calculated optimal dosages were 7.5 and 9.5 mg/kg q24h by the IV and IM routes, respectively. For less susceptible bacteria, a dose increase should be evaluated. To treat caracara by the IV route against microorganisms with MIC ≤0.25 μg/mL, the dose should be higher than the 5 mg/kg used in our study, but possible side effects derived from an increase in the IV dose and efficacy in sick birds should be assessed. © 2013 by the Association of Avian Veterinarians.
author	Orozco, Maria Marcela
author_facet	Orozco, Maria Marcela
author_sort	Orozco, Maria Marcela
title	Pharmacokinetic and pharmacodynamic properties of enrofloxacin in Southern crested caracaras (Caracara plancus)
title_short	Pharmacokinetic and pharmacodynamic properties of enrofloxacin in Southern crested caracaras (Caracara plancus)
title_full	Pharmacokinetic and pharmacodynamic properties of enrofloxacin in Southern crested caracaras (Caracara plancus)
title_fullStr	Pharmacokinetic and pharmacodynamic properties of enrofloxacin in Southern crested caracaras (Caracara plancus)
title_full_unstemmed	Pharmacokinetic and pharmacodynamic properties of enrofloxacin in Southern crested caracaras (Caracara plancus)
title_sort	pharmacokinetic and pharmacodynamic properties of enrofloxacin in southern crested caracaras (caracara plancus)
publishDate	2013
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10826742_v27_n3_p180_Waxman http://hdl.handle.net/20.500.12110/paper_10826742_v27_n3_p180_Waxman
work_keys_str_mv	AT orozcomariamarcela pharmacokineticandpharmacodynamicpropertiesofenrofloxacininsoutherncrestedcaracarascaracaraplancus
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Pharmacokinetic and pharmacodynamic properties of enrofloxacin in Southern crested caracaras (Caracara plancus)

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