A pivotal role for galectin-1 in fetomaternal tolerance
A successful pregnancy requires synchronized adaptation of maternal immune-endocrine mechanisms to the fetus. Here we show that galectin-1 (Gal-1), an immunoregulatory glycan-binding protein, has a pivotal role in conferring fetomaternal tolerance. Consistently with a marked decrease in Gal-1 expres...
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paper:paper_10788956_v13_n12_p1450_Blois2023-06-08T16:05:36Z A pivotal role for galectin-1 in fetomaternal tolerance Ilarregui, Juan Martín Toscano, Marta Alicia galectin 1 animal cell animal experiment article controlled study cytokine release dendritic cell fetoplacental unit fetus wastage immunoregulation in vivo culture mouse nonhuman pregnancy disorder priority journal protein binding protein expression regulatory T lymphocyte Animals CD4-Positive T-Lymphocytes Female Galectin 1 Gene Expression Regulation, Developmental Histocompatibility, Maternal-Fetal Immune Tolerance Interleukin-2 Receptor alpha Subunit Mice Mice, Transgenic Polysaccharides Pregnancy Pregnancy, Animal T-Lymphocytes, Regulatory Transplantation, Homologous Mus A successful pregnancy requires synchronized adaptation of maternal immune-endocrine mechanisms to the fetus. Here we show that galectin-1 (Gal-1), an immunoregulatory glycan-binding protein, has a pivotal role in conferring fetomaternal tolerance. Consistently with a marked decrease in Gal-1 expression during failing pregnancies, Gal-1-deficient (Lgals1-/-) mice showed higher rates of fetal loss compared to wild-type mice in allogeneic matings, whereas fetal survival was unaffected in syngeneic matings. Treatment with recombinant Gal-1 prevented fetal loss and restored tolerance through multiple mechanisms, including the induction of tolerogenic dendritic cells, which in turn promoted the expansion of interleukin-10 (IL-10)-secreting regulatory T cells in vivo. Accordingly, Gal-1's protective effects were abrogated in mice depleted of regulatory T cells or deficient in IL-10. In addition, we provide evidence for synergy between Gal-1 and progesterone in the maintenance of pregnancy. Thus, Gal-1 is a pivotal regulator of fetomaternal tolerance that has potential therapeutic implications in threatened pregnancies. © 2007 Nature Publishing Group. Fil:Ilarregui, J.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Toscano, M.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2007 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10788956_v13_n12_p1450_Blois http://hdl.handle.net/20.500.12110/paper_10788956_v13_n12_p1450_Blois |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
galectin 1 animal cell animal experiment article controlled study cytokine release dendritic cell fetoplacental unit fetus wastage immunoregulation in vivo culture mouse nonhuman pregnancy disorder priority journal protein binding protein expression regulatory T lymphocyte Animals CD4-Positive T-Lymphocytes Female Galectin 1 Gene Expression Regulation, Developmental Histocompatibility, Maternal-Fetal Immune Tolerance Interleukin-2 Receptor alpha Subunit Mice Mice, Transgenic Polysaccharides Pregnancy Pregnancy, Animal T-Lymphocytes, Regulatory Transplantation, Homologous Mus |
| spellingShingle |
galectin 1 animal cell animal experiment article controlled study cytokine release dendritic cell fetoplacental unit fetus wastage immunoregulation in vivo culture mouse nonhuman pregnancy disorder priority journal protein binding protein expression regulatory T lymphocyte Animals CD4-Positive T-Lymphocytes Female Galectin 1 Gene Expression Regulation, Developmental Histocompatibility, Maternal-Fetal Immune Tolerance Interleukin-2 Receptor alpha Subunit Mice Mice, Transgenic Polysaccharides Pregnancy Pregnancy, Animal T-Lymphocytes, Regulatory Transplantation, Homologous Mus Ilarregui, Juan Martín Toscano, Marta Alicia A pivotal role for galectin-1 in fetomaternal tolerance |
| topic_facet |
galectin 1 animal cell animal experiment article controlled study cytokine release dendritic cell fetoplacental unit fetus wastage immunoregulation in vivo culture mouse nonhuman pregnancy disorder priority journal protein binding protein expression regulatory T lymphocyte Animals CD4-Positive T-Lymphocytes Female Galectin 1 Gene Expression Regulation, Developmental Histocompatibility, Maternal-Fetal Immune Tolerance Interleukin-2 Receptor alpha Subunit Mice Mice, Transgenic Polysaccharides Pregnancy Pregnancy, Animal T-Lymphocytes, Regulatory Transplantation, Homologous Mus |
| description |
A successful pregnancy requires synchronized adaptation of maternal immune-endocrine mechanisms to the fetus. Here we show that galectin-1 (Gal-1), an immunoregulatory glycan-binding protein, has a pivotal role in conferring fetomaternal tolerance. Consistently with a marked decrease in Gal-1 expression during failing pregnancies, Gal-1-deficient (Lgals1-/-) mice showed higher rates of fetal loss compared to wild-type mice in allogeneic matings, whereas fetal survival was unaffected in syngeneic matings. Treatment with recombinant Gal-1 prevented fetal loss and restored tolerance through multiple mechanisms, including the induction of tolerogenic dendritic cells, which in turn promoted the expansion of interleukin-10 (IL-10)-secreting regulatory T cells in vivo. Accordingly, Gal-1's protective effects were abrogated in mice depleted of regulatory T cells or deficient in IL-10. In addition, we provide evidence for synergy between Gal-1 and progesterone in the maintenance of pregnancy. Thus, Gal-1 is a pivotal regulator of fetomaternal tolerance that has potential therapeutic implications in threatened pregnancies. © 2007 Nature Publishing Group. |
| author |
Ilarregui, Juan Martín Toscano, Marta Alicia |
| author_facet |
Ilarregui, Juan Martín Toscano, Marta Alicia |
| author_sort |
Ilarregui, Juan Martín |
| title |
A pivotal role for galectin-1 in fetomaternal tolerance |
| title_short |
A pivotal role for galectin-1 in fetomaternal tolerance |
| title_full |
A pivotal role for galectin-1 in fetomaternal tolerance |
| title_fullStr |
A pivotal role for galectin-1 in fetomaternal tolerance |
| title_full_unstemmed |
A pivotal role for galectin-1 in fetomaternal tolerance |
| title_sort |
pivotal role for galectin-1 in fetomaternal tolerance |
| publishDate |
2007 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10788956_v13_n12_p1450_Blois http://hdl.handle.net/20.500.12110/paper_10788956_v13_n12_p1450_Blois |
| work_keys_str_mv |
AT ilarreguijuanmartin apivotalroleforgalectin1infetomaternaltolerance AT toscanomartaalicia apivotalroleforgalectin1infetomaternaltolerance AT ilarreguijuanmartin pivotalroleforgalectin1infetomaternaltolerance AT toscanomartaalicia pivotalroleforgalectin1infetomaternaltolerance |
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1768546597818335232 |