Identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (HN-2) and tris(2-chloroethyl)amine (HN-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry
The nitrogen blister agents HN-2 (bis(2-chloroethyl)methylamine) and HN-3 (tris(2-chloroethyl)amine) were directly analyzed on the surface of soil samples using ion trap secondary ion mass spectrometry (SIMS). In the presence of water, HN-1 (bis(2-choroethyl)ethylamine), HN-2 and HN-3 undergo hydrol...
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2000
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10765174_v35_n12_p1460_Cabrera http://hdl.handle.net/20.500.12110/paper_10765174_v35_n12_p1460_Cabrera |
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paper:paper_10765174_v35_n12_p1460_Cabrera2023-06-08T16:05:22Z Identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (HN-2) and tris(2-chloroethyl)amine (HN-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry Cabrera, Gabriela Myriam Seldes, Alicia Marta Chemical weapons agents HN-2 HN-3 Secondary ion mass spectrometry Surface analysis Vesicants chlormethine nitrogen derivative trichlormethine analytic method article chemical analysis chemical reaction hydrolysis mass spectrometry polymerization priority journal reaction analysis soil 3,4-Methylenedioxyamphetamine Chemical Warfare Agents Ethanolamines Hydrolysis Irritants Mechlorethamine Nitrogen Mustard Compounds Soil Spectrometry, Mass, Secondary Ion The nitrogen blister agents HN-2 (bis(2-chloroethyl)methylamine) and HN-3 (tris(2-chloroethyl)amine) were directly analyzed on the surface of soil samples using ion trap secondary ion mass spectrometry (SIMS). In the presence of water, HN-1 (bis(2-choroethyl)ethylamine), HN-2 and HN-3 undergo hydrolysis to form N-ethyldiethanolamine, N-methyldiethanolamine and triethanolamine (TEA), respectively; these compounds can be readily detected as adsorbed species on soil particles. When soil samples spiked with HN-3 in alcohol were analyzed, 2-alkoxyethylamine derivatives were observed on the sample surfaces. This result shows that nitrogen blister agents will undergo condensation reactions with nucleophilic compounds and emphasizes the need for an analytical methodology capable of detecting a range of degradation and condensation products on environmental surfaces. The ability of ion trap SIMS to isolate and accumulate ions, and then perform tandem mass spectrometric analysis improves the detection of low-abundance surface contaminants and the selectivity of the technique. Utilizing these techniques, the limits of detection for HN-3 were studied as a function of surface coverage. It was found that HN-3 could be detected at a surface coverage of 0.01 monolayer, which corresponds to 20 ppm (mass/mass) for a soil having a surface area of 2.2 m2 g-1. TEA, the exhaustive hydrolysis product of HN-3, was detected at a surface coverage of 0.001 monolayer, which corresponds to 0.86 ppm. Copyright © 2000 John Wiley & Sons, Ltd. Fil:Cabrera, G.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Seldes, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2000 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10765174_v35_n12_p1460_Cabrera http://hdl.handle.net/20.500.12110/paper_10765174_v35_n12_p1460_Cabrera |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Chemical weapons agents HN-2 HN-3 Secondary ion mass spectrometry Surface analysis Vesicants chlormethine nitrogen derivative trichlormethine analytic method article chemical analysis chemical reaction hydrolysis mass spectrometry polymerization priority journal reaction analysis soil 3,4-Methylenedioxyamphetamine Chemical Warfare Agents Ethanolamines Hydrolysis Irritants Mechlorethamine Nitrogen Mustard Compounds Soil Spectrometry, Mass, Secondary Ion |
| spellingShingle |
Chemical weapons agents HN-2 HN-3 Secondary ion mass spectrometry Surface analysis Vesicants chlormethine nitrogen derivative trichlormethine analytic method article chemical analysis chemical reaction hydrolysis mass spectrometry polymerization priority journal reaction analysis soil 3,4-Methylenedioxyamphetamine Chemical Warfare Agents Ethanolamines Hydrolysis Irritants Mechlorethamine Nitrogen Mustard Compounds Soil Spectrometry, Mass, Secondary Ion Cabrera, Gabriela Myriam Seldes, Alicia Marta Identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (HN-2) and tris(2-chloroethyl)amine (HN-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry |
| topic_facet |
Chemical weapons agents HN-2 HN-3 Secondary ion mass spectrometry Surface analysis Vesicants chlormethine nitrogen derivative trichlormethine analytic method article chemical analysis chemical reaction hydrolysis mass spectrometry polymerization priority journal reaction analysis soil 3,4-Methylenedioxyamphetamine Chemical Warfare Agents Ethanolamines Hydrolysis Irritants Mechlorethamine Nitrogen Mustard Compounds Soil Spectrometry, Mass, Secondary Ion |
| description |
The nitrogen blister agents HN-2 (bis(2-chloroethyl)methylamine) and HN-3 (tris(2-chloroethyl)amine) were directly analyzed on the surface of soil samples using ion trap secondary ion mass spectrometry (SIMS). In the presence of water, HN-1 (bis(2-choroethyl)ethylamine), HN-2 and HN-3 undergo hydrolysis to form N-ethyldiethanolamine, N-methyldiethanolamine and triethanolamine (TEA), respectively; these compounds can be readily detected as adsorbed species on soil particles. When soil samples spiked with HN-3 in alcohol were analyzed, 2-alkoxyethylamine derivatives were observed on the sample surfaces. This result shows that nitrogen blister agents will undergo condensation reactions with nucleophilic compounds and emphasizes the need for an analytical methodology capable of detecting a range of degradation and condensation products on environmental surfaces. The ability of ion trap SIMS to isolate and accumulate ions, and then perform tandem mass spectrometric analysis improves the detection of low-abundance surface contaminants and the selectivity of the technique. Utilizing these techniques, the limits of detection for HN-3 were studied as a function of surface coverage. It was found that HN-3 could be detected at a surface coverage of 0.01 monolayer, which corresponds to 20 ppm (mass/mass) for a soil having a surface area of 2.2 m2 g-1. TEA, the exhaustive hydrolysis product of HN-3, was detected at a surface coverage of 0.001 monolayer, which corresponds to 0.86 ppm. Copyright © 2000 John Wiley & Sons, Ltd. |
| author |
Cabrera, Gabriela Myriam Seldes, Alicia Marta |
| author_facet |
Cabrera, Gabriela Myriam Seldes, Alicia Marta |
| author_sort |
Cabrera, Gabriela Myriam |
| title |
Identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (HN-2) and tris(2-chloroethyl)amine (HN-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry |
| title_short |
Identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (HN-2) and tris(2-chloroethyl)amine (HN-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry |
| title_full |
Identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (HN-2) and tris(2-chloroethyl)amine (HN-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry |
| title_fullStr |
Identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (HN-2) and tris(2-chloroethyl)amine (HN-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry |
| title_full_unstemmed |
Identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (HN-2) and tris(2-chloroethyl)amine (HN-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry |
| title_sort |
identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (hn-2) and tris(2-chloroethyl)amine (hn-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry |
| publishDate |
2000 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10765174_v35_n12_p1460_Cabrera http://hdl.handle.net/20.500.12110/paper_10765174_v35_n12_p1460_Cabrera |
| work_keys_str_mv |
AT cabreragabrielamyriam identificationofthenitrogenbasedblisteragentsbis2chloroethylmethylaminehn2andtris2chloroethylaminehn3andtheirhydrolysisproductsonsoilusingiontrapsecondaryionmassspectrometry AT seldesaliciamarta identificationofthenitrogenbasedblisteragentsbis2chloroethylmethylaminehn2andtris2chloroethylaminehn3andtheirhydrolysisproductsonsoilusingiontrapsecondaryionmassspectrometry |
| _version_ |
1768544607094702080 |