Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer

Numerous regulatory programs have been identified that contribute to the restoration of homeostasis at the conclusion of immune responses and to safeguarding against the detrimental effects of chronic inflammation and autoimmune pathology. Malignant cells may usurp these pathways to create immunosup...

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Autor principal:	Croci Russo, Diego Omar
Publicado:	2012
Materias:	carcinoembryonic antigen related cell adhesion molecule 1 CD22 antigen cytotoxic T lymphocyte antigen 4 dectin 1 galectin glycan glycosidase glycosyltransferase immunoglobulin interleukin 10 interleukin 12 interleukin 6 lectin mitogen activated protein kinase protein tyrosine kinase tumor necrosis factor receptor 1 antigen presenting cell autoimmune disease autoimmunity carbohydrate synthesis cell death cell migration cell survival cytokine production endocytosis enzyme activation glycosylation immune response immunocompetent cell immunological tolerance inflammation lymphocyte activation neoplasm priority journal protein interaction protein motif protein phosphorylation protein structure regulatory mechanism regulatory T lymphocyte review Animals Antigen-Presenting Cells Autoimmunity Cell Death Humans Immune Tolerance Inflammation Lectins Lymphocyte Activation Mice Models, Immunological Neoplasms Polysaccharides Signal Transduction T-Lymphocytes
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747613_v36_n3_p322_Rabinovich http://hdl.handle.net/20.500.12110/paper_10747613_v36_n3_p322_Rabinovich
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_10747613_v36_n3_p322_Rabinovich
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spelling	paper:paper_10747613_v36_n3_p322_Rabinovich2023-06-08T16:05:10Z Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer Croci Russo, Diego Omar carcinoembryonic antigen related cell adhesion molecule 1 CD22 antigen cytotoxic T lymphocyte antigen 4 dectin 1 galectin glycan glycosidase glycosyltransferase immunoglobulin interleukin 10 interleukin 12 interleukin 6 lectin mitogen activated protein kinase protein tyrosine kinase tumor necrosis factor receptor 1 antigen presenting cell autoimmune disease autoimmunity carbohydrate synthesis cell death cell migration cell survival cytokine production endocytosis enzyme activation glycosylation immune response immunocompetent cell immunological tolerance inflammation lymphocyte activation neoplasm priority journal protein interaction protein motif protein phosphorylation protein structure regulatory mechanism regulatory T lymphocyte review Animals Antigen-Presenting Cells Autoimmunity Cell Death Humans Immune Tolerance Inflammation Lectins Lymphocyte Activation Mice Models, Immunological Neoplasms Polysaccharides Signal Transduction T-Lymphocytes Numerous regulatory programs have been identified that contribute to the restoration of homeostasis at the conclusion of immune responses and to safeguarding against the detrimental effects of chronic inflammation and autoimmune pathology. Malignant cells may usurp these pathways to create immunosuppressive networks that thwart antitumor responses. Herein we review the role of endogenous lectins (C-type lectins, siglecs, and galectins) and specific N- and O-glycans generated by the coordinated action of glycosyltransferases and glycosidases that together promote regulatory signals that control immune cell homeostasis. We also discuss the mechanisms by which glycan-dependent regulatory programs integrate into canonical circuits that amplify or silence immune responses related to autoimmunity and neoplastic disease. © 2012 Elsevier Inc.. Fil:Croci, D.O. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747613_v36_n3_p322_Rabinovich http://hdl.handle.net/20.500.12110/paper_10747613_v36_n3_p322_Rabinovich
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	carcinoembryonic antigen related cell adhesion molecule 1 CD22 antigen cytotoxic T lymphocyte antigen 4 dectin 1 galectin glycan glycosidase glycosyltransferase immunoglobulin interleukin 10 interleukin 12 interleukin 6 lectin mitogen activated protein kinase protein tyrosine kinase tumor necrosis factor receptor 1 antigen presenting cell autoimmune disease autoimmunity carbohydrate synthesis cell death cell migration cell survival cytokine production endocytosis enzyme activation glycosylation immune response immunocompetent cell immunological tolerance inflammation lymphocyte activation neoplasm priority journal protein interaction protein motif protein phosphorylation protein structure regulatory mechanism regulatory T lymphocyte review Animals Antigen-Presenting Cells Autoimmunity Cell Death Humans Immune Tolerance Inflammation Lectins Lymphocyte Activation Mice Models, Immunological Neoplasms Polysaccharides Signal Transduction T-Lymphocytes
spellingShingle	carcinoembryonic antigen related cell adhesion molecule 1 CD22 antigen cytotoxic T lymphocyte antigen 4 dectin 1 galectin glycan glycosidase glycosyltransferase immunoglobulin interleukin 10 interleukin 12 interleukin 6 lectin mitogen activated protein kinase protein tyrosine kinase tumor necrosis factor receptor 1 antigen presenting cell autoimmune disease autoimmunity carbohydrate synthesis cell death cell migration cell survival cytokine production endocytosis enzyme activation glycosylation immune response immunocompetent cell immunological tolerance inflammation lymphocyte activation neoplasm priority journal protein interaction protein motif protein phosphorylation protein structure regulatory mechanism regulatory T lymphocyte review Animals Antigen-Presenting Cells Autoimmunity Cell Death Humans Immune Tolerance Inflammation Lectins Lymphocyte Activation Mice Models, Immunological Neoplasms Polysaccharides Signal Transduction T-Lymphocytes Croci Russo, Diego Omar Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer
topic_facet	carcinoembryonic antigen related cell adhesion molecule 1 CD22 antigen cytotoxic T lymphocyte antigen 4 dectin 1 galectin glycan glycosidase glycosyltransferase immunoglobulin interleukin 10 interleukin 12 interleukin 6 lectin mitogen activated protein kinase protein tyrosine kinase tumor necrosis factor receptor 1 antigen presenting cell autoimmune disease autoimmunity carbohydrate synthesis cell death cell migration cell survival cytokine production endocytosis enzyme activation glycosylation immune response immunocompetent cell immunological tolerance inflammation lymphocyte activation neoplasm priority journal protein interaction protein motif protein phosphorylation protein structure regulatory mechanism regulatory T lymphocyte review Animals Antigen-Presenting Cells Autoimmunity Cell Death Humans Immune Tolerance Inflammation Lectins Lymphocyte Activation Mice Models, Immunological Neoplasms Polysaccharides Signal Transduction T-Lymphocytes
description	Numerous regulatory programs have been identified that contribute to the restoration of homeostasis at the conclusion of immune responses and to safeguarding against the detrimental effects of chronic inflammation and autoimmune pathology. Malignant cells may usurp these pathways to create immunosuppressive networks that thwart antitumor responses. Herein we review the role of endogenous lectins (C-type lectins, siglecs, and galectins) and specific N- and O-glycans generated by the coordinated action of glycosyltransferases and glycosidases that together promote regulatory signals that control immune cell homeostasis. We also discuss the mechanisms by which glycan-dependent regulatory programs integrate into canonical circuits that amplify or silence immune responses related to autoimmunity and neoplastic disease. © 2012 Elsevier Inc..
author	Croci Russo, Diego Omar
author_facet	Croci Russo, Diego Omar
author_sort	Croci Russo, Diego Omar
title	Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer
title_short	Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer
title_full	Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer
title_fullStr	Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer
title_full_unstemmed	Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer
title_sort	regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer
publishDate	2012
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747613_v36_n3_p322_Rabinovich http://hdl.handle.net/20.500.12110/paper_10747613_v36_n3_p322_Rabinovich
work_keys_str_mv	AT crocirussodiegoomar regulatorycircuitsmediatedbylectinglycaninteractionsinautoimmunityandcancer
_version_	1768542999248109568

Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer

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