Dissociation between memory reactivation and its behavioral expression: Scopolamine interferes with memory expression without disrupting long-term storage
The reconsolidation hypothesis has challenged the traditional view of fixed memories after consolidation. Reconsolidation studies have disclosed that the mechanisms mediating memory retrieval and the mechanisms that underlie the behavioral expression of memory can be dissociated, offering a new pros...
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2012
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v98_n3_p235_Caffaro http://hdl.handle.net/20.500.12110/paper_10747427_v98_n3_p235_Caffaro |
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paper:paper_10747427_v98_n3_p235_Caffaro2023-06-08T16:05:10Z Dissociation between memory reactivation and its behavioral expression: Scopolamine interferes with memory expression without disrupting long-term storage Suarez, Luis Daniel Delorenzi, Alejandro Amnesia Chasmagnathus Memory expression Reconsolidation Retrieval Scopolamine scopolamine amnesia animal behavior animal experiment animal model article associative memory Chasmagnathus granulatus conditioning controlled study crab escape behavior facilitation long term memory male memory consolidation memory reactivation memory reconsolidation mental dissociation nonhuman stimulus visual danger stimulus Amnesia Animals Behavior, Animal Brachyura Male Memory Memory, Long-Term Muscarinic Antagonists Scopolamine Hydrobromide The reconsolidation hypothesis has challenged the traditional view of fixed memories after consolidation. Reconsolidation studies have disclosed that the mechanisms mediating memory retrieval and the mechanisms that underlie the behavioral expression of memory can be dissociated, offering a new prospect for understanding the nature of experimental amnesia. The muscarinic antagonist scopolamine has been used for decades to induce experimental amnesias The goal of the present study is to determine whether the amnesic effects of scopolamine are due to storage (or retrieval) deficits or, alternatively, to a decrease in the long-term memory expression of a consolidated long-term memory. In the crab Chasmagnathus memory model, we found that scopolamine-induced amnesia can be reverted by facilitation after reminder presentation. This recovery of memory expression was reconsolidation specific since a reminder that does not triggers reconsolidation process did not allow the recovery. A higher dose (5 μg/g) of scopolamine induced an amnesic effect that could not be reverted through reconsolidation, and thus it can be explained as an interference with memory storage and/or retrieval mechanisms. These results, showing that an effective amnesic dose of scopolamine (100. ng/g) negatively modulates long-term memory expression but not memory storage in the crab Chasmagnathus, are consistent with the concept that dissociable processes underlie the mechanisms mediating memory reactivation and the behavioral expression of memory. © 2012 Elsevier Inc. Fil:Suárez, L.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Delorenzi, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v98_n3_p235_Caffaro http://hdl.handle.net/20.500.12110/paper_10747427_v98_n3_p235_Caffaro |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Amnesia Chasmagnathus Memory expression Reconsolidation Retrieval Scopolamine scopolamine amnesia animal behavior animal experiment animal model article associative memory Chasmagnathus granulatus conditioning controlled study crab escape behavior facilitation long term memory male memory consolidation memory reactivation memory reconsolidation mental dissociation nonhuman stimulus visual danger stimulus Amnesia Animals Behavior, Animal Brachyura Male Memory Memory, Long-Term Muscarinic Antagonists Scopolamine Hydrobromide |
| spellingShingle |
Amnesia Chasmagnathus Memory expression Reconsolidation Retrieval Scopolamine scopolamine amnesia animal behavior animal experiment animal model article associative memory Chasmagnathus granulatus conditioning controlled study crab escape behavior facilitation long term memory male memory consolidation memory reactivation memory reconsolidation mental dissociation nonhuman stimulus visual danger stimulus Amnesia Animals Behavior, Animal Brachyura Male Memory Memory, Long-Term Muscarinic Antagonists Scopolamine Hydrobromide Suarez, Luis Daniel Delorenzi, Alejandro Dissociation between memory reactivation and its behavioral expression: Scopolamine interferes with memory expression without disrupting long-term storage |
| topic_facet |
Amnesia Chasmagnathus Memory expression Reconsolidation Retrieval Scopolamine scopolamine amnesia animal behavior animal experiment animal model article associative memory Chasmagnathus granulatus conditioning controlled study crab escape behavior facilitation long term memory male memory consolidation memory reactivation memory reconsolidation mental dissociation nonhuman stimulus visual danger stimulus Amnesia Animals Behavior, Animal Brachyura Male Memory Memory, Long-Term Muscarinic Antagonists Scopolamine Hydrobromide |
| description |
The reconsolidation hypothesis has challenged the traditional view of fixed memories after consolidation. Reconsolidation studies have disclosed that the mechanisms mediating memory retrieval and the mechanisms that underlie the behavioral expression of memory can be dissociated, offering a new prospect for understanding the nature of experimental amnesia. The muscarinic antagonist scopolamine has been used for decades to induce experimental amnesias The goal of the present study is to determine whether the amnesic effects of scopolamine are due to storage (or retrieval) deficits or, alternatively, to a decrease in the long-term memory expression of a consolidated long-term memory. In the crab Chasmagnathus memory model, we found that scopolamine-induced amnesia can be reverted by facilitation after reminder presentation. This recovery of memory expression was reconsolidation specific since a reminder that does not triggers reconsolidation process did not allow the recovery. A higher dose (5 μg/g) of scopolamine induced an amnesic effect that could not be reverted through reconsolidation, and thus it can be explained as an interference with memory storage and/or retrieval mechanisms. These results, showing that an effective amnesic dose of scopolamine (100. ng/g) negatively modulates long-term memory expression but not memory storage in the crab Chasmagnathus, are consistent with the concept that dissociable processes underlie the mechanisms mediating memory reactivation and the behavioral expression of memory. © 2012 Elsevier Inc. |
| author |
Suarez, Luis Daniel Delorenzi, Alejandro |
| author_facet |
Suarez, Luis Daniel Delorenzi, Alejandro |
| author_sort |
Suarez, Luis Daniel |
| title |
Dissociation between memory reactivation and its behavioral expression: Scopolamine interferes with memory expression without disrupting long-term storage |
| title_short |
Dissociation between memory reactivation and its behavioral expression: Scopolamine interferes with memory expression without disrupting long-term storage |
| title_full |
Dissociation between memory reactivation and its behavioral expression: Scopolamine interferes with memory expression without disrupting long-term storage |
| title_fullStr |
Dissociation between memory reactivation and its behavioral expression: Scopolamine interferes with memory expression without disrupting long-term storage |
| title_full_unstemmed |
Dissociation between memory reactivation and its behavioral expression: Scopolamine interferes with memory expression without disrupting long-term storage |
| title_sort |
dissociation between memory reactivation and its behavioral expression: scopolamine interferes with memory expression without disrupting long-term storage |
| publishDate |
2012 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v98_n3_p235_Caffaro http://hdl.handle.net/20.500.12110/paper_10747427_v98_n3_p235_Caffaro |
| work_keys_str_mv |
AT suarezluisdaniel dissociationbetweenmemoryreactivationanditsbehavioralexpressionscopolamineinterfereswithmemoryexpressionwithoutdisruptinglongtermstorage AT delorenzialejandro dissociationbetweenmemoryreactivationanditsbehavioralexpressionscopolamineinterfereswithmemoryexpressionwithoutdisruptinglongtermstorage |
| _version_ |
1768544971150852096 |