Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation
It is widely known that pre-training systemic administration of the muscarinic antagonist scopolamine (SCP) (0.5mg/kg, i.p.) leads to anterograde memory impairment in retention tests. The administration of the α7-nicotinic receptor agonist choline (Ch) in the dorsal hippocampus (0.8μg/hippocampus) i...
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2012
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v98_n2_p112_Blake http://hdl.handle.net/20.500.12110/paper_10747427_v98_n2_p112_Blake |
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paper:paper_10747427_v98_n2_p112_Blake2023-06-08T16:05:09Z Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation Delorenzi, Alejandro Cholinergic system Memory expression Memory reconsolidation Memory retrieval Scopolamine-induced amnesia choline bitartrate scopolamine animal experiment animal model article behavior brain function controlled study drug effect male memory consolidation memory disorder mental performance mental task mental test mouse neuromodulation nonhuman time treatment response Animals Avoidance Learning Choline Hippocampus Male Memory Memory Disorders Mice Muscarinic Antagonists Nicotinic Agonists Nootropic Agents Retention (Psychology) Scopolamine Hydrobromide Time Factors It is widely known that pre-training systemic administration of the muscarinic antagonist scopolamine (SCP) (0.5mg/kg, i.p.) leads to anterograde memory impairment in retention tests. The administration of the α7-nicotinic receptor agonist choline (Ch) in the dorsal hippocampus (0.8μg/hippocampus) immediately after memory reactivation allowed recovery from scopolamine-induced memory impairment. This effect of Ch was time-dependent, and retention performance was not affected in drug-treated mice that were not subjected to memory reactivation, suggesting that the performance effects are not due to non-specific effects of the drug. The effects of Ch also depended on the age of the reactivated memory. Altogether, our results suggest that Ch exerts its effects by modulating memory reconsolidation, and that the memory impairment induced by low doses of SCP is a memory expression failure and not a storage deficit. Therefore, reconsolidation, among other functions, might serve to change memory expression in later tests. Summarizing, our results open new avenues about the behavioral significance and the physiological functions of memory reconsolidation, providing new strategies for recovering memories from some types of amnesia. © 2012 Elsevier Inc. Fil:Delorenzi, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v98_n2_p112_Blake http://hdl.handle.net/20.500.12110/paper_10747427_v98_n2_p112_Blake |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cholinergic system Memory expression Memory reconsolidation Memory retrieval Scopolamine-induced amnesia choline bitartrate scopolamine animal experiment animal model article behavior brain function controlled study drug effect male memory consolidation memory disorder mental performance mental task mental test mouse neuromodulation nonhuman time treatment response Animals Avoidance Learning Choline Hippocampus Male Memory Memory Disorders Mice Muscarinic Antagonists Nicotinic Agonists Nootropic Agents Retention (Psychology) Scopolamine Hydrobromide Time Factors |
| spellingShingle |
Cholinergic system Memory expression Memory reconsolidation Memory retrieval Scopolamine-induced amnesia choline bitartrate scopolamine animal experiment animal model article behavior brain function controlled study drug effect male memory consolidation memory disorder mental performance mental task mental test mouse neuromodulation nonhuman time treatment response Animals Avoidance Learning Choline Hippocampus Male Memory Memory Disorders Mice Muscarinic Antagonists Nicotinic Agonists Nootropic Agents Retention (Psychology) Scopolamine Hydrobromide Time Factors Delorenzi, Alejandro Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation |
| topic_facet |
Cholinergic system Memory expression Memory reconsolidation Memory retrieval Scopolamine-induced amnesia choline bitartrate scopolamine animal experiment animal model article behavior brain function controlled study drug effect male memory consolidation memory disorder mental performance mental task mental test mouse neuromodulation nonhuman time treatment response Animals Avoidance Learning Choline Hippocampus Male Memory Memory Disorders Mice Muscarinic Antagonists Nicotinic Agonists Nootropic Agents Retention (Psychology) Scopolamine Hydrobromide Time Factors |
| description |
It is widely known that pre-training systemic administration of the muscarinic antagonist scopolamine (SCP) (0.5mg/kg, i.p.) leads to anterograde memory impairment in retention tests. The administration of the α7-nicotinic receptor agonist choline (Ch) in the dorsal hippocampus (0.8μg/hippocampus) immediately after memory reactivation allowed recovery from scopolamine-induced memory impairment. This effect of Ch was time-dependent, and retention performance was not affected in drug-treated mice that were not subjected to memory reactivation, suggesting that the performance effects are not due to non-specific effects of the drug. The effects of Ch also depended on the age of the reactivated memory. Altogether, our results suggest that Ch exerts its effects by modulating memory reconsolidation, and that the memory impairment induced by low doses of SCP is a memory expression failure and not a storage deficit. Therefore, reconsolidation, among other functions, might serve to change memory expression in later tests. Summarizing, our results open new avenues about the behavioral significance and the physiological functions of memory reconsolidation, providing new strategies for recovering memories from some types of amnesia. © 2012 Elsevier Inc. |
| author |
Delorenzi, Alejandro |
| author_facet |
Delorenzi, Alejandro |
| author_sort |
Delorenzi, Alejandro |
| title |
Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation |
| title_short |
Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation |
| title_full |
Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation |
| title_fullStr |
Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation |
| title_full_unstemmed |
Choline reverses scopolamine-induced memory impairment by improving memory reconsolidation |
| title_sort |
choline reverses scopolamine-induced memory impairment by improving memory reconsolidation |
| publishDate |
2012 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v98_n2_p112_Blake http://hdl.handle.net/20.500.12110/paper_10747427_v98_n2_p112_Blake |
| work_keys_str_mv |
AT delorenzialejandro cholinereversesscopolamineinducedmemoryimpairmentbyimprovingmemoryreconsolidation |
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