Angiotensin modulates long-term memory expression but not long-term memory storage in the crab Chasmagnathus
Memory reconsolidation is a dynamic process in which a previously consolidated memory becomes labile following reactivation by a reminder. In a previous study in the crab Chasmagnathus memory model, we showed that a water-shortage episode, via angiotensin modulation during reconsolidation, could rev...
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2010
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v94_n4_p509_Frenkel http://hdl.handle.net/20.500.12110/paper_10747427_v94_n4_p509_Frenkel |
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paper:paper_10747427_v94_n4_p509_Frenkel2023-06-08T16:05:09Z Angiotensin modulates long-term memory expression but not long-term memory storage in the crab Chasmagnathus Frenkel, Lia Suarez, Luis Daniel Delorenzi, Alejandro Angiotensin Chasmagnathus Consolidation Expression Memory Modulatory system Reconsolidation angiotensin II messenger RNA saralasin adult animal animal behavior animal experiment article associative memory controlled study crab long term memory male memory consolidation nonhuman RNA transcription RNA translation water deprivation Angiotensin II Angiotensin II Type 1 Receptor Blockers Animals Association Learning Brachyura Environment Male Memory, Long-Term Mental Recall Recognition (Psychology) Saralasin Water Deprivation Memory reconsolidation is a dynamic process in which a previously consolidated memory becomes labile following reactivation by a reminder. In a previous study in the crab Chasmagnathus memory model, we showed that a water-shortage episode, via angiotensin modulation during reconsolidation, could reveal a memory that otherwise remains unexpressed: weakly trained animals cannot reveal long-term memory (LTM) except when an episode of noticeable ethological meaning, water deprivation, is contingent upon reconsolidation. However, these results are at variance with two of our previous interpretations: weak training protocols do not build LTM and angiotensin II modulates the strength of the information storing process. A parsimonious hypothesis is that in Chasmagnathus angiotensins regulate LTM expression, but not LTM storage. Here, we tested three predictions of this hypothesis. First, the well-known retrograde amnesic effect of the angiotensin II antagonist saralasin is not due to interference on memory storage, but to modulation of memory expression. Second, the recovery of the LTM memory expression of the apparently amnesic retrograde effect produced by saralasin, through the water-shortage episode contingent upon reconsolidation, must be reconsolidation specific. Consequently, summation-like effects and retrieval deficits cannot explain these results because of the parametric conditions of reconsolidation. Third, weak training protocols build an unexpressed LTM that requires mRNA transcription and translation, a diagnostic characteristic of LTM. Results show that angiotensin modulates LTM expression but not LTM memory storage in the crab Chasmagnathus. The results lead us to suggest that, in Chasmagnathus, LTM expression - the process of gaining appreciable control over behavior of the reactivated trace in the retrieval session - may be considered a distinct attribute of its long-term storage. This strategy, a positive modulation during reconsolidation, is proposed to distinguish between memories that can be reactivated, labilized and are not expressed, and memories that are not stored long term, obliterated or altered in other retrieval mechanisms. © 2010 Elsevier Inc. Fil:Frenkel, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Suárez, L.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Delorenzi, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2010 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v94_n4_p509_Frenkel http://hdl.handle.net/20.500.12110/paper_10747427_v94_n4_p509_Frenkel |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Angiotensin Chasmagnathus Consolidation Expression Memory Modulatory system Reconsolidation angiotensin II messenger RNA saralasin adult animal animal behavior animal experiment article associative memory controlled study crab long term memory male memory consolidation nonhuman RNA transcription RNA translation water deprivation Angiotensin II Angiotensin II Type 1 Receptor Blockers Animals Association Learning Brachyura Environment Male Memory, Long-Term Mental Recall Recognition (Psychology) Saralasin Water Deprivation |
| spellingShingle |
Angiotensin Chasmagnathus Consolidation Expression Memory Modulatory system Reconsolidation angiotensin II messenger RNA saralasin adult animal animal behavior animal experiment article associative memory controlled study crab long term memory male memory consolidation nonhuman RNA transcription RNA translation water deprivation Angiotensin II Angiotensin II Type 1 Receptor Blockers Animals Association Learning Brachyura Environment Male Memory, Long-Term Mental Recall Recognition (Psychology) Saralasin Water Deprivation Frenkel, Lia Suarez, Luis Daniel Delorenzi, Alejandro Angiotensin modulates long-term memory expression but not long-term memory storage in the crab Chasmagnathus |
| topic_facet |
Angiotensin Chasmagnathus Consolidation Expression Memory Modulatory system Reconsolidation angiotensin II messenger RNA saralasin adult animal animal behavior animal experiment article associative memory controlled study crab long term memory male memory consolidation nonhuman RNA transcription RNA translation water deprivation Angiotensin II Angiotensin II Type 1 Receptor Blockers Animals Association Learning Brachyura Environment Male Memory, Long-Term Mental Recall Recognition (Psychology) Saralasin Water Deprivation |
| description |
Memory reconsolidation is a dynamic process in which a previously consolidated memory becomes labile following reactivation by a reminder. In a previous study in the crab Chasmagnathus memory model, we showed that a water-shortage episode, via angiotensin modulation during reconsolidation, could reveal a memory that otherwise remains unexpressed: weakly trained animals cannot reveal long-term memory (LTM) except when an episode of noticeable ethological meaning, water deprivation, is contingent upon reconsolidation. However, these results are at variance with two of our previous interpretations: weak training protocols do not build LTM and angiotensin II modulates the strength of the information storing process. A parsimonious hypothesis is that in Chasmagnathus angiotensins regulate LTM expression, but not LTM storage. Here, we tested three predictions of this hypothesis. First, the well-known retrograde amnesic effect of the angiotensin II antagonist saralasin is not due to interference on memory storage, but to modulation of memory expression. Second, the recovery of the LTM memory expression of the apparently amnesic retrograde effect produced by saralasin, through the water-shortage episode contingent upon reconsolidation, must be reconsolidation specific. Consequently, summation-like effects and retrieval deficits cannot explain these results because of the parametric conditions of reconsolidation. Third, weak training protocols build an unexpressed LTM that requires mRNA transcription and translation, a diagnostic characteristic of LTM. Results show that angiotensin modulates LTM expression but not LTM memory storage in the crab Chasmagnathus. The results lead us to suggest that, in Chasmagnathus, LTM expression - the process of gaining appreciable control over behavior of the reactivated trace in the retrieval session - may be considered a distinct attribute of its long-term storage. This strategy, a positive modulation during reconsolidation, is proposed to distinguish between memories that can be reactivated, labilized and are not expressed, and memories that are not stored long term, obliterated or altered in other retrieval mechanisms. © 2010 Elsevier Inc. |
| author |
Frenkel, Lia Suarez, Luis Daniel Delorenzi, Alejandro |
| author_facet |
Frenkel, Lia Suarez, Luis Daniel Delorenzi, Alejandro |
| author_sort |
Frenkel, Lia |
| title |
Angiotensin modulates long-term memory expression but not long-term memory storage in the crab Chasmagnathus |
| title_short |
Angiotensin modulates long-term memory expression but not long-term memory storage in the crab Chasmagnathus |
| title_full |
Angiotensin modulates long-term memory expression but not long-term memory storage in the crab Chasmagnathus |
| title_fullStr |
Angiotensin modulates long-term memory expression but not long-term memory storage in the crab Chasmagnathus |
| title_full_unstemmed |
Angiotensin modulates long-term memory expression but not long-term memory storage in the crab Chasmagnathus |
| title_sort |
angiotensin modulates long-term memory expression but not long-term memory storage in the crab chasmagnathus |
| publishDate |
2010 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v94_n4_p509_Frenkel http://hdl.handle.net/20.500.12110/paper_10747427_v94_n4_p509_Frenkel |
| work_keys_str_mv |
AT frenkellia angiotensinmodulateslongtermmemoryexpressionbutnotlongtermmemorystorageinthecrabchasmagnathus AT suarezluisdaniel angiotensinmodulateslongtermmemoryexpressionbutnotlongtermmemorystorageinthecrabchasmagnathus AT delorenzialejandro angiotensinmodulateslongtermmemoryexpressionbutnotlongtermmemorystorageinthecrabchasmagnathus |
| _version_ |
1768545239626153984 |