Reconsolidation in humans opens up declarative memory to the entrance of new information
A consolidated memory recalled by a reminder enters a vulnerability phase (labilization), followed by a process of stabilization (reconsolidation). Several authors have suggested that the labilization of the consolidated memory makes the incorporation of new information possible. Here, we demonstrat...
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2010
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v93_n1_p77_Forcato http://hdl.handle.net/20.500.12110/paper_10747427_v93_n1_p77_Forcato |
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paper:paper_10747427_v93_n1_p77_Forcato2023-06-08T16:05:08Z Reconsolidation in humans opens up declarative memory to the entrance of new information Declarative memory Labilization-reconsolidation Memory updating Reminder Retrieval interference adult article controlled study declarative memory female human human experiment information retrieval male memory consolidation mental performance normal human paired associate learning recall reinforcement reminder system state dependent learning verbal memory Adult Cognition Cues Female Humans Male Memory Models, Psychological Neuropsychological Tests Speech Perception Time Factors Young Adult A consolidated memory recalled by a reminder enters a vulnerability phase (labilization), followed by a process of stabilization (reconsolidation). Several authors have suggested that the labilization of the consolidated memory makes the incorporation of new information possible. Here, we demonstrate updating in the framework of memory declarative reconsolidation in humans by giving an opportune verbal instruction. Volunteers learn an association between five cue-syllables (L1) and their respective response-syllables. Twenty-four hours later, the paired-associate verbal memory is labilized by exposing the subjects to the reminder, and then they receive the verbal Instruction of adding three new cue-response syllables (INFO) with their respective responses to the former list of five. The new information is incorporated into the single former L1-memory and both INFO and L1 are successfully retrieved on the third day. However, when the Instruction is not preceded by a proper reminder, or when the instruction omits the order of adding the INFO into the former L1-memory, we observed interference in retrieval of both the original and the new information, suggesting that they are encoded independently and coexist as separate memories. © 2009 Elsevier Inc. All rights reserved. 2010 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v93_n1_p77_Forcato http://hdl.handle.net/20.500.12110/paper_10747427_v93_n1_p77_Forcato |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Declarative memory Labilization-reconsolidation Memory updating Reminder Retrieval interference adult article controlled study declarative memory female human human experiment information retrieval male memory consolidation mental performance normal human paired associate learning recall reinforcement reminder system state dependent learning verbal memory Adult Cognition Cues Female Humans Male Memory Models, Psychological Neuropsychological Tests Speech Perception Time Factors Young Adult |
| spellingShingle |
Declarative memory Labilization-reconsolidation Memory updating Reminder Retrieval interference adult article controlled study declarative memory female human human experiment information retrieval male memory consolidation mental performance normal human paired associate learning recall reinforcement reminder system state dependent learning verbal memory Adult Cognition Cues Female Humans Male Memory Models, Psychological Neuropsychological Tests Speech Perception Time Factors Young Adult Reconsolidation in humans opens up declarative memory to the entrance of new information |
| topic_facet |
Declarative memory Labilization-reconsolidation Memory updating Reminder Retrieval interference adult article controlled study declarative memory female human human experiment information retrieval male memory consolidation mental performance normal human paired associate learning recall reinforcement reminder system state dependent learning verbal memory Adult Cognition Cues Female Humans Male Memory Models, Psychological Neuropsychological Tests Speech Perception Time Factors Young Adult |
| description |
A consolidated memory recalled by a reminder enters a vulnerability phase (labilization), followed by a process of stabilization (reconsolidation). Several authors have suggested that the labilization of the consolidated memory makes the incorporation of new information possible. Here, we demonstrate updating in the framework of memory declarative reconsolidation in humans by giving an opportune verbal instruction. Volunteers learn an association between five cue-syllables (L1) and their respective response-syllables. Twenty-four hours later, the paired-associate verbal memory is labilized by exposing the subjects to the reminder, and then they receive the verbal Instruction of adding three new cue-response syllables (INFO) with their respective responses to the former list of five. The new information is incorporated into the single former L1-memory and both INFO and L1 are successfully retrieved on the third day. However, when the Instruction is not preceded by a proper reminder, or when the instruction omits the order of adding the INFO into the former L1-memory, we observed interference in retrieval of both the original and the new information, suggesting that they are encoded independently and coexist as separate memories. © 2009 Elsevier Inc. All rights reserved. |
| title |
Reconsolidation in humans opens up declarative memory to the entrance of new information |
| title_short |
Reconsolidation in humans opens up declarative memory to the entrance of new information |
| title_full |
Reconsolidation in humans opens up declarative memory to the entrance of new information |
| title_fullStr |
Reconsolidation in humans opens up declarative memory to the entrance of new information |
| title_full_unstemmed |
Reconsolidation in humans opens up declarative memory to the entrance of new information |
| title_sort |
reconsolidation in humans opens up declarative memory to the entrance of new information |
| publishDate |
2010 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v93_n1_p77_Forcato http://hdl.handle.net/20.500.12110/paper_10747427_v93_n1_p77_Forcato |
| _version_ |
1768545842829983744 |