Memory expression is independent of memory labilization/reconsolidation

There is growing evidence that certain reactivation conditions restrict the onset of both the destabilization phase and the restabilization process or reconsolidation. However, it is not yet clear how changes in memory expression during the retrieval experience can influence the emergence of the lab...

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Autores principales:	Barreiro, Karina Andrea, Suarez, Luis Daniel, Delorenzi, Alejandro
Publicado:	2013
Materias:	Amnesia APV CNQX Memory expression Reconsolidation Retrieval 2 amino 5 phosphonovaleric acid 6 cyano 7 nitro 2,3 quinoxalinedione amnesia animal experiment animal model article Chasmagnathus granulatus controlled study crab information retrieval long term memory male memory memory consolidation memory expression memory labilization nonhuman reinforcement 6-Cyano-7-nitroquinoxaline-2,3-dione Animals Association Learning Brachyura Escape Reaction Excitatory Amino Acid Antagonists Freezing Reaction, Cataleptic Memory Mental Recall Retention (Psychology) Valine
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v106_n_p283_Barreiro http://hdl.handle.net/20.500.12110/paper_10747427_v106_n_p283_Barreiro
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_10747427_v106_n_p283_Barreiro
record_format	dspace
spelling	paper:paper_10747427_v106_n_p283_Barreiro2023-06-08T16:05:02Z Memory expression is independent of memory labilization/reconsolidation Barreiro, Karina Andrea Suarez, Luis Daniel Delorenzi, Alejandro Amnesia APV CNQX Memory expression Reconsolidation Retrieval 2 amino 5 phosphonovaleric acid 6 cyano 7 nitro 2,3 quinoxalinedione amnesia animal experiment animal model article Chasmagnathus granulatus controlled study crab information retrieval long term memory male memory memory consolidation memory expression memory labilization nonhuman reinforcement Amnesia APV CNQX Memory expression Reconsolidation Retrieval 6-Cyano-7-nitroquinoxaline-2,3-dione Animals Association Learning Brachyura Escape Reaction Excitatory Amino Acid Antagonists Freezing Reaction, Cataleptic Memory Mental Recall Retention (Psychology) Valine There is growing evidence that certain reactivation conditions restrict the onset of both the destabilization phase and the restabilization process or reconsolidation. However, it is not yet clear how changes in memory expression during the retrieval experience can influence the emergence of the labilization/reconsolidation process. To address this issue, we used the context-signal memory model of Chasmagnathus. In this paradigm a short reminder that does not include reinforcement allows us to evaluate memory labilization and reconsolidation, whereas a short but reinforced reminder restricts the onset of such a process. The current study investigated the effects of the glutamate antagonists, APV (0.6 or 1.5. μg/g) and CNQX (1. μg/g), prior to the reminder session on both behavioral expression and the reconsolidation process. Under conditions where the reminder does not initiate the labilization/reconsolidation process, APV prevented memory expression without affecting long-term memory retention. In contrast, APV induced amnesic effects in the long-term when administered before a reminder session that triggers reconsolidation. Under the present parametric conditions, the administration of CNQX prior to the reminder that allows memory to enter reconsolidation impairs this process without disrupting memory expression. Overall, the present findings suggest that memory reactivation - but not memory expression- is necessary for labilization and reconsolidation. Retrieval and memory expression therefore appear not to be interchangeable concepts. © 2013 Elsevier Inc. Fil:Barreiro, K.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Suárez, L.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Delorenzi, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v106_n_p283_Barreiro http://hdl.handle.net/20.500.12110/paper_10747427_v106_n_p283_Barreiro
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Amnesia APV CNQX Memory expression Reconsolidation Retrieval 2 amino 5 phosphonovaleric acid 6 cyano 7 nitro 2,3 quinoxalinedione amnesia animal experiment animal model article Chasmagnathus granulatus controlled study crab information retrieval long term memory male memory memory consolidation memory expression memory labilization nonhuman reinforcement Amnesia APV CNQX Memory expression Reconsolidation Retrieval 6-Cyano-7-nitroquinoxaline-2,3-dione Animals Association Learning Brachyura Escape Reaction Excitatory Amino Acid Antagonists Freezing Reaction, Cataleptic Memory Mental Recall Retention (Psychology) Valine
spellingShingle	Amnesia APV CNQX Memory expression Reconsolidation Retrieval 2 amino 5 phosphonovaleric acid 6 cyano 7 nitro 2,3 quinoxalinedione amnesia animal experiment animal model article Chasmagnathus granulatus controlled study crab information retrieval long term memory male memory memory consolidation memory expression memory labilization nonhuman reinforcement Amnesia APV CNQX Memory expression Reconsolidation Retrieval 6-Cyano-7-nitroquinoxaline-2,3-dione Animals Association Learning Brachyura Escape Reaction Excitatory Amino Acid Antagonists Freezing Reaction, Cataleptic Memory Mental Recall Retention (Psychology) Valine Barreiro, Karina Andrea Suarez, Luis Daniel Delorenzi, Alejandro Memory expression is independent of memory labilization/reconsolidation
topic_facet	Amnesia APV CNQX Memory expression Reconsolidation Retrieval 2 amino 5 phosphonovaleric acid 6 cyano 7 nitro 2,3 quinoxalinedione amnesia animal experiment animal model article Chasmagnathus granulatus controlled study crab information retrieval long term memory male memory memory consolidation memory expression memory labilization nonhuman reinforcement Amnesia APV CNQX Memory expression Reconsolidation Retrieval 6-Cyano-7-nitroquinoxaline-2,3-dione Animals Association Learning Brachyura Escape Reaction Excitatory Amino Acid Antagonists Freezing Reaction, Cataleptic Memory Mental Recall Retention (Psychology) Valine
description	There is growing evidence that certain reactivation conditions restrict the onset of both the destabilization phase and the restabilization process or reconsolidation. However, it is not yet clear how changes in memory expression during the retrieval experience can influence the emergence of the labilization/reconsolidation process. To address this issue, we used the context-signal memory model of Chasmagnathus. In this paradigm a short reminder that does not include reinforcement allows us to evaluate memory labilization and reconsolidation, whereas a short but reinforced reminder restricts the onset of such a process. The current study investigated the effects of the glutamate antagonists, APV (0.6 or 1.5. μg/g) and CNQX (1. μg/g), prior to the reminder session on both behavioral expression and the reconsolidation process. Under conditions where the reminder does not initiate the labilization/reconsolidation process, APV prevented memory expression without affecting long-term memory retention. In contrast, APV induced amnesic effects in the long-term when administered before a reminder session that triggers reconsolidation. Under the present parametric conditions, the administration of CNQX prior to the reminder that allows memory to enter reconsolidation impairs this process without disrupting memory expression. Overall, the present findings suggest that memory reactivation - but not memory expression- is necessary for labilization and reconsolidation. Retrieval and memory expression therefore appear not to be interchangeable concepts. © 2013 Elsevier Inc.
author	Barreiro, Karina Andrea Suarez, Luis Daniel Delorenzi, Alejandro
author_facet	Barreiro, Karina Andrea Suarez, Luis Daniel Delorenzi, Alejandro
author_sort	Barreiro, Karina Andrea
title	Memory expression is independent of memory labilization/reconsolidation
title_short	Memory expression is independent of memory labilization/reconsolidation
title_full	Memory expression is independent of memory labilization/reconsolidation
title_fullStr	Memory expression is independent of memory labilization/reconsolidation
title_full_unstemmed	Memory expression is independent of memory labilization/reconsolidation
title_sort	memory expression is independent of memory labilization/reconsolidation
publishDate	2013
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v106_n_p283_Barreiro http://hdl.handle.net/20.500.12110/paper_10747427_v106_n_p283_Barreiro
work_keys_str_mv	AT barreirokarinaandrea memoryexpressionisindependentofmemorylabilizationreconsolidation AT suarezluisdaniel memoryexpressionisindependentofmemorylabilizationreconsolidation AT delorenzialejandro memoryexpressionisindependentofmemorylabilizationreconsolidation
_version_	1768545155006070784

Memory expression is independent of memory labilization/reconsolidation

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