Activation of the transcription factor NF-κB by retrieval is required for long-term memory reconsolidation
Several studies support that stored memories undergo a new period of consolidation after retrieval. It is not known whether this process, termed reconsolidation, requires the same transcriptional mechanisms involved in consolidation. Increasing evidence supports the participation of the transcriptio...
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Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10720502_v12_n1_p23_Merlo http://hdl.handle.net/20.500.12110/paper_10720502_v12_n1_p23_Merlo |
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paper:paper_10720502_v12_n1_p23_Merlo2023-06-08T16:04:47Z Activation of the transcription factor NF-κB by retrieval is required for long-term memory reconsolidation Merlo, Emiliano Freudenthal, Ramiro Angel María Romano, Arturo Gabriel immunoglobulin enhancer binding protein salazosulfapyridine transcription factor animal behavior animal experiment animal tissue article controlled study long term memory male memory consolidation molecular biology nonhuman priority journal protein function training Amnesia Animals Anti-Inflammatory Agents, Non-Steroidal Brachyura Brain Chemistry Conditioning, Classical Electrophoretic Mobility Shift Assay Indomethacin Male Memory NF-kappa B Photic Stimulation Sulfasalazine Several studies support that stored memories undergo a new period of consolidation after retrieval. It is not known whether this process, termed reconsolidation, requires the same transcriptional mechanisms involved in consolidation. Increasing evidence supports the participation of the transcription factor NF-κB in memory. This was initially demonstrated in the crab Chasmagnathus model of associative contextual memory, in which re-exposure to the training context induces a well characterized reconsolidation process. Here we studied the role of NF-κB in reconsolidation. NF-κB was specifically activated in trained animals re-exposed to the training context but not to a different context. NF-κB was not activated when animals were re-exposed to the context after a weak training protocol insufficient to induce long-term memory. A specific inhibitor of the NF-κB pathway, sulfasalazine, impaired reconsolidation when administered 20 min before re-exposure to the training context but was not effective when a different context was used. These findings indicate for the first time that NF-κB is activated specifically by retrieval and that this activation is required for memory reconsolidation, supporting the view that this molecular mechanism is required in both consolidation and reconsolidation. Fil:Merlo, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Freudenthal, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2005 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10720502_v12_n1_p23_Merlo http://hdl.handle.net/20.500.12110/paper_10720502_v12_n1_p23_Merlo |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
immunoglobulin enhancer binding protein salazosulfapyridine transcription factor animal behavior animal experiment animal tissue article controlled study long term memory male memory consolidation molecular biology nonhuman priority journal protein function training Amnesia Animals Anti-Inflammatory Agents, Non-Steroidal Brachyura Brain Chemistry Conditioning, Classical Electrophoretic Mobility Shift Assay Indomethacin Male Memory NF-kappa B Photic Stimulation Sulfasalazine |
spellingShingle |
immunoglobulin enhancer binding protein salazosulfapyridine transcription factor animal behavior animal experiment animal tissue article controlled study long term memory male memory consolidation molecular biology nonhuman priority journal protein function training Amnesia Animals Anti-Inflammatory Agents, Non-Steroidal Brachyura Brain Chemistry Conditioning, Classical Electrophoretic Mobility Shift Assay Indomethacin Male Memory NF-kappa B Photic Stimulation Sulfasalazine Merlo, Emiliano Freudenthal, Ramiro Angel María Romano, Arturo Gabriel Activation of the transcription factor NF-κB by retrieval is required for long-term memory reconsolidation |
topic_facet |
immunoglobulin enhancer binding protein salazosulfapyridine transcription factor animal behavior animal experiment animal tissue article controlled study long term memory male memory consolidation molecular biology nonhuman priority journal protein function training Amnesia Animals Anti-Inflammatory Agents, Non-Steroidal Brachyura Brain Chemistry Conditioning, Classical Electrophoretic Mobility Shift Assay Indomethacin Male Memory NF-kappa B Photic Stimulation Sulfasalazine |
description |
Several studies support that stored memories undergo a new period of consolidation after retrieval. It is not known whether this process, termed reconsolidation, requires the same transcriptional mechanisms involved in consolidation. Increasing evidence supports the participation of the transcription factor NF-κB in memory. This was initially demonstrated in the crab Chasmagnathus model of associative contextual memory, in which re-exposure to the training context induces a well characterized reconsolidation process. Here we studied the role of NF-κB in reconsolidation. NF-κB was specifically activated in trained animals re-exposed to the training context but not to a different context. NF-κB was not activated when animals were re-exposed to the context after a weak training protocol insufficient to induce long-term memory. A specific inhibitor of the NF-κB pathway, sulfasalazine, impaired reconsolidation when administered 20 min before re-exposure to the training context but was not effective when a different context was used. These findings indicate for the first time that NF-κB is activated specifically by retrieval and that this activation is required for memory reconsolidation, supporting the view that this molecular mechanism is required in both consolidation and reconsolidation. |
author |
Merlo, Emiliano Freudenthal, Ramiro Angel María Romano, Arturo Gabriel |
author_facet |
Merlo, Emiliano Freudenthal, Ramiro Angel María Romano, Arturo Gabriel |
author_sort |
Merlo, Emiliano |
title |
Activation of the transcription factor NF-κB by retrieval is required for long-term memory reconsolidation |
title_short |
Activation of the transcription factor NF-κB by retrieval is required for long-term memory reconsolidation |
title_full |
Activation of the transcription factor NF-κB by retrieval is required for long-term memory reconsolidation |
title_fullStr |
Activation of the transcription factor NF-κB by retrieval is required for long-term memory reconsolidation |
title_full_unstemmed |
Activation of the transcription factor NF-κB by retrieval is required for long-term memory reconsolidation |
title_sort |
activation of the transcription factor nf-κb by retrieval is required for long-term memory reconsolidation |
publishDate |
2005 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10720502_v12_n1_p23_Merlo http://hdl.handle.net/20.500.12110/paper_10720502_v12_n1_p23_Merlo |
work_keys_str_mv |
AT merloemiliano activationofthetranscriptionfactornfkbbyretrievalisrequiredforlongtermmemoryreconsolidation AT freudenthalramiroangelmaria activationofthetranscriptionfactornfkbbyretrievalisrequiredforlongtermmemoryreconsolidation AT romanoarturogabriel activationofthetranscriptionfactornfkbbyretrievalisrequiredforlongtermmemoryreconsolidation |
_version_ |
1768541949292183552 |