Galectins in hematological malignancies
Purpose of Review: Galectins are a family of lectin molecules that have emerged as key players in inflammation and tumor progresssion by displaying intracellular and extracellular activities. This review describes the recent advances on the role of galectins in hematological neoplasms. RECENT FINDIN...
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2013
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10656251_v20_n4_p327_Giordano http://hdl.handle.net/20.500.12110/paper_10656251_v20_n4_p327_Giordano |
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paper:paper_10656251_v20_n4_p327_Giordano2023-06-08T16:04:14Z Galectins in hematological malignancies Galectins Hodgkin?s lymphoma Lymphomas Myeloma Non-Hodgkin?s lymphoma ecalectin galectin galectin 1 galectin 10 galectin 11 galectin 12 galectin 13 galectin 14 galectin 15 galectin 2 galectin 3 galectin 4 galectin 5 galectin 6 galectin 7 latent membrane protein 1 latent membrane protein 2 messenger RNA mitogen activated protein kinase 1 mitogen activated protein kinase 3 transcription factor AP 1 unclassified drug acute granulocytic leukemia angiogenesis cellular immunity chronic lymphatic leukemia chronic myeloid leukemia cutaneous T cell lymphoma dendritic cell disease association follicular lymphoma hematologic malignancy Hodgkin disease human large cell lymphoma lymph node lymphoproliferative disease multiple myeloma priority journal protein expression review signal transduction spleen T lymphocyte tumor invasion Galectins Hematologic Neoplasms Humans Immunity, Cellular Neoplasm Proteins T-Lymphocytes Purpose of Review: Galectins are a family of lectin molecules that have emerged as key players in inflammation and tumor progresssion by displaying intracellular and extracellular activities. This review describes the recent advances on the role of galectins in hematological neoplasms. RECENT FINDINGS: Galectin-1 and galectin-3 are the best studied galectins in oncohematology. Increased expression of galectin-1 has been associated with tumor progression in HodgkinÊs lymphoma and chronic lymphocytic leukemia, whereas galectin-3 plays a supporting role in chronic myelogenous leukemia and multiple myeloma. Functional studies have assigned a key role for galectin-1 as a negative regulator of T-cell immunity in HodgkinÊs lymphoma and cutaneous T-cell lymphoma. Of therapeutic interest is the development of agents with the capacity to interfere with galectin functions. SUMMARY: Current knowledge indicates a key role for galectins in hematological neoplasms by favoring the growth and survival of tumor cells and facilitating tumor immune escape. Intervention using specific galectin inhibitors is emerging as an attractive therapeutic option to alter the course of these malignancies. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10656251_v20_n4_p327_Giordano http://hdl.handle.net/20.500.12110/paper_10656251_v20_n4_p327_Giordano |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Galectins Hodgkin?s lymphoma Lymphomas Myeloma Non-Hodgkin?s lymphoma ecalectin galectin galectin 1 galectin 10 galectin 11 galectin 12 galectin 13 galectin 14 galectin 15 galectin 2 galectin 3 galectin 4 galectin 5 galectin 6 galectin 7 latent membrane protein 1 latent membrane protein 2 messenger RNA mitogen activated protein kinase 1 mitogen activated protein kinase 3 transcription factor AP 1 unclassified drug acute granulocytic leukemia angiogenesis cellular immunity chronic lymphatic leukemia chronic myeloid leukemia cutaneous T cell lymphoma dendritic cell disease association follicular lymphoma hematologic malignancy Hodgkin disease human large cell lymphoma lymph node lymphoproliferative disease multiple myeloma priority journal protein expression review signal transduction spleen T lymphocyte tumor invasion Galectins Hematologic Neoplasms Humans Immunity, Cellular Neoplasm Proteins T-Lymphocytes |
| spellingShingle |
Galectins Hodgkin?s lymphoma Lymphomas Myeloma Non-Hodgkin?s lymphoma ecalectin galectin galectin 1 galectin 10 galectin 11 galectin 12 galectin 13 galectin 14 galectin 15 galectin 2 galectin 3 galectin 4 galectin 5 galectin 6 galectin 7 latent membrane protein 1 latent membrane protein 2 messenger RNA mitogen activated protein kinase 1 mitogen activated protein kinase 3 transcription factor AP 1 unclassified drug acute granulocytic leukemia angiogenesis cellular immunity chronic lymphatic leukemia chronic myeloid leukemia cutaneous T cell lymphoma dendritic cell disease association follicular lymphoma hematologic malignancy Hodgkin disease human large cell lymphoma lymph node lymphoproliferative disease multiple myeloma priority journal protein expression review signal transduction spleen T lymphocyte tumor invasion Galectins Hematologic Neoplasms Humans Immunity, Cellular Neoplasm Proteins T-Lymphocytes Galectins in hematological malignancies |
| topic_facet |
Galectins Hodgkin?s lymphoma Lymphomas Myeloma Non-Hodgkin?s lymphoma ecalectin galectin galectin 1 galectin 10 galectin 11 galectin 12 galectin 13 galectin 14 galectin 15 galectin 2 galectin 3 galectin 4 galectin 5 galectin 6 galectin 7 latent membrane protein 1 latent membrane protein 2 messenger RNA mitogen activated protein kinase 1 mitogen activated protein kinase 3 transcription factor AP 1 unclassified drug acute granulocytic leukemia angiogenesis cellular immunity chronic lymphatic leukemia chronic myeloid leukemia cutaneous T cell lymphoma dendritic cell disease association follicular lymphoma hematologic malignancy Hodgkin disease human large cell lymphoma lymph node lymphoproliferative disease multiple myeloma priority journal protein expression review signal transduction spleen T lymphocyte tumor invasion Galectins Hematologic Neoplasms Humans Immunity, Cellular Neoplasm Proteins T-Lymphocytes |
| description |
Purpose of Review: Galectins are a family of lectin molecules that have emerged as key players in inflammation and tumor progresssion by displaying intracellular and extracellular activities. This review describes the recent advances on the role of galectins in hematological neoplasms. RECENT FINDINGS: Galectin-1 and galectin-3 are the best studied galectins in oncohematology. Increased expression of galectin-1 has been associated with tumor progression in HodgkinÊs lymphoma and chronic lymphocytic leukemia, whereas galectin-3 plays a supporting role in chronic myelogenous leukemia and multiple myeloma. Functional studies have assigned a key role for galectin-1 as a negative regulator of T-cell immunity in HodgkinÊs lymphoma and cutaneous T-cell lymphoma. Of therapeutic interest is the development of agents with the capacity to interfere with galectin functions. SUMMARY: Current knowledge indicates a key role for galectins in hematological neoplasms by favoring the growth and survival of tumor cells and facilitating tumor immune escape. Intervention using specific galectin inhibitors is emerging as an attractive therapeutic option to alter the course of these malignancies. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins. |
| title |
Galectins in hematological malignancies |
| title_short |
Galectins in hematological malignancies |
| title_full |
Galectins in hematological malignancies |
| title_fullStr |
Galectins in hematological malignancies |
| title_full_unstemmed |
Galectins in hematological malignancies |
| title_sort |
galectins in hematological malignancies |
| publishDate |
2013 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10656251_v20_n4_p327_Giordano http://hdl.handle.net/20.500.12110/paper_10656251_v20_n4_p327_Giordano |
| _version_ |
1768544606919589888 |