Lipases as catalysts in synthesis of fine chemicals
The application of lipases as catalysts in the synthesis of an intermediate of alfuzosin and lapyrium chloride is described. In the first case, the one-pot procedure to obtain the intermediate involves the treatment of tetrahydrofuroic acid with ethanol in the presence of Candida antarctica lipase f...
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2012
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10643745_v861_n_p445_Baldessari http://hdl.handle.net/20.500.12110/paper_10643745_v861_n_p445_Baldessari |
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paper:paper_10643745_v861_n_p445_Baldessari2023-06-08T16:04:10Z Lipases as catalysts in synthesis of fine chemicals Alfuzosin Esterification and aminolysis reactions Fine chemicals Lapyrium chloride Lipases acetic acid derivative alfuzosin biological product chloroacetic acid diamine fungal protein furan derivative lapyrium lipase B, Candida antarctica pyridinium derivative quinazoline derivative triacylglycerol lipase article biocatalysis Candida chemistry green chemistry synthesis Acetic Acids Biocatalysis Biological Agents Candida Diamines Fungal Proteins Furans Green Chemistry Technology Lipase Pyridinium Compounds Quinazolines Candida antarctica The application of lipases as catalysts in the synthesis of an intermediate of alfuzosin and lapyrium chloride is described. In the first case, the one-pot procedure to obtain the intermediate involves the treatment of tetrahydrofuroic acid with ethanol in the presence of Candida antarctica lipase followed by the addition of N-methyl-1,3-diaminopropane. In the second part of the chapter, an efficient route for large-scale preparation of lapyrium chloride is developed from chloroacetic acid in four steps, three of them enzymatic. Due to the chemoselective behavior of the lipases, both products described in the present chapter were obtained in a high degree of purity and yield, applying mild reaction conditions, and following a low environmental impact methodology. © 2012 Springer Science+Business Media New York. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10643745_v861_n_p445_Baldessari http://hdl.handle.net/20.500.12110/paper_10643745_v861_n_p445_Baldessari |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Alfuzosin Esterification and aminolysis reactions Fine chemicals Lapyrium chloride Lipases acetic acid derivative alfuzosin biological product chloroacetic acid diamine fungal protein furan derivative lapyrium lipase B, Candida antarctica pyridinium derivative quinazoline derivative triacylglycerol lipase article biocatalysis Candida chemistry green chemistry synthesis Acetic Acids Biocatalysis Biological Agents Candida Diamines Fungal Proteins Furans Green Chemistry Technology Lipase Pyridinium Compounds Quinazolines Candida antarctica |
| spellingShingle |
Alfuzosin Esterification and aminolysis reactions Fine chemicals Lapyrium chloride Lipases acetic acid derivative alfuzosin biological product chloroacetic acid diamine fungal protein furan derivative lapyrium lipase B, Candida antarctica pyridinium derivative quinazoline derivative triacylglycerol lipase article biocatalysis Candida chemistry green chemistry synthesis Acetic Acids Biocatalysis Biological Agents Candida Diamines Fungal Proteins Furans Green Chemistry Technology Lipase Pyridinium Compounds Quinazolines Candida antarctica Lipases as catalysts in synthesis of fine chemicals |
| topic_facet |
Alfuzosin Esterification and aminolysis reactions Fine chemicals Lapyrium chloride Lipases acetic acid derivative alfuzosin biological product chloroacetic acid diamine fungal protein furan derivative lapyrium lipase B, Candida antarctica pyridinium derivative quinazoline derivative triacylglycerol lipase article biocatalysis Candida chemistry green chemistry synthesis Acetic Acids Biocatalysis Biological Agents Candida Diamines Fungal Proteins Furans Green Chemistry Technology Lipase Pyridinium Compounds Quinazolines Candida antarctica |
| description |
The application of lipases as catalysts in the synthesis of an intermediate of alfuzosin and lapyrium chloride is described. In the first case, the one-pot procedure to obtain the intermediate involves the treatment of tetrahydrofuroic acid with ethanol in the presence of Candida antarctica lipase followed by the addition of N-methyl-1,3-diaminopropane. In the second part of the chapter, an efficient route for large-scale preparation of lapyrium chloride is developed from chloroacetic acid in four steps, three of them enzymatic. Due to the chemoselective behavior of the lipases, both products described in the present chapter were obtained in a high degree of purity and yield, applying mild reaction conditions, and following a low environmental impact methodology. © 2012 Springer Science+Business Media New York. |
| title |
Lipases as catalysts in synthesis of fine chemicals |
| title_short |
Lipases as catalysts in synthesis of fine chemicals |
| title_full |
Lipases as catalysts in synthesis of fine chemicals |
| title_fullStr |
Lipases as catalysts in synthesis of fine chemicals |
| title_full_unstemmed |
Lipases as catalysts in synthesis of fine chemicals |
| title_sort |
lipases as catalysts in synthesis of fine chemicals |
| publishDate |
2012 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10643745_v861_n_p445_Baldessari http://hdl.handle.net/20.500.12110/paper_10643745_v861_n_p445_Baldessari |
| _version_ |
1768546264240095232 |