Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria?

The effects of isoflurane, a commonly used volatile anesthetic, on the activity of some haem enzymes in liver, kidney, and blood, and glucose content in liver and blood were studied. Mice were injected with different doses of the drug (0.5-6 mL/kg) and killed at varying intervals after injection (5-...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Buzaleh, Ana María, Batlle, Alcira María del Carmen
Publicado:	1992
Materias:	Acute Intermittent Porphyria Anesthesia Isoflurane 5 aminolevulinate synthase glucose heme oxygenase inhalation anesthetic agent isoflurane porphobilinogen deaminase porphobilinogenase unclassified drug acute intermittent porphyria anesthesia animal experiment animal model animal tissue article blood controlled study dose time effect relation enzyme activity glucose metabolism heme synthesis intraperitoneal drug administration kidney liver mouse nonhuman priority journal Animal Disease Models, Animal Dose-Response Relationship, Drug Enzyme Activation Glucose Kidney Liver Mice Porphyria, Acute Intermittent Support, Non-U.S. Gov't
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10568719_v28_n4_p191_Buzaleh http://hdl.handle.net/20.500.12110/paper_10568719_v28_n4_p191_Buzaleh
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_10568719_v28_n4_p191_Buzaleh
record_format	dspace
spelling	paper:paper_10568719_v28_n4_p191_Buzaleh2023-06-08T16:03:18Z Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria? Buzaleh, Ana María Batlle, Alcira María del Carmen Acute Intermittent Porphyria Anesthesia Isoflurane 5 aminolevulinate synthase glucose heme oxygenase inhalation anesthetic agent isoflurane porphobilinogen deaminase porphobilinogenase unclassified drug acute intermittent porphyria anesthesia animal experiment animal model animal tissue article blood controlled study dose time effect relation enzyme activity glucose metabolism heme synthesis intraperitoneal drug administration kidney liver mouse nonhuman priority journal Animal Disease Models, Animal Dose-Response Relationship, Drug Enzyme Activation Glucose Isoflurane Kidney Liver Mice Porphyria, Acute Intermittent Support, Non-U.S. Gov't The effects of isoflurane, a commonly used volatile anesthetic, on the activity of some haem enzymes in liver, kidney, and blood, and glucose content in liver and blood were studied. Mice were injected with different doses of the drug (0.5-6 mL/kg) and killed at varying intervals after injection (5-240 min). Within this dose range, optimal effects on alteration of haem metabolism were obtained at 2 mL/kg. The time-response profile for each enzyme was different. Blood porphobilinogenase (PBGase) and deaminase showed lower activities 20 min after anesthesia. This diminution coupled with the induction of δ-aminolevulinate synthetase activity observed soon after anesthesia (5 min) would fit well with the expected biochemical changes occurring in acute intermittent porphyria, indicating that this may be a suitable animal model for this disease. © 1992. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Del Carmen Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1992 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10568719_v28_n4_p191_Buzaleh http://hdl.handle.net/20.500.12110/paper_10568719_v28_n4_p191_Buzaleh
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Acute Intermittent Porphyria Anesthesia Isoflurane 5 aminolevulinate synthase glucose heme oxygenase inhalation anesthetic agent isoflurane porphobilinogen deaminase porphobilinogenase unclassified drug acute intermittent porphyria anesthesia animal experiment animal model animal tissue article blood controlled study dose time effect relation enzyme activity glucose metabolism heme synthesis intraperitoneal drug administration kidney liver mouse nonhuman priority journal Animal Disease Models, Animal Dose-Response Relationship, Drug Enzyme Activation Glucose Isoflurane Kidney Liver Mice Porphyria, Acute Intermittent Support, Non-U.S. Gov't
spellingShingle	Acute Intermittent Porphyria Anesthesia Isoflurane 5 aminolevulinate synthase glucose heme oxygenase inhalation anesthetic agent isoflurane porphobilinogen deaminase porphobilinogenase unclassified drug acute intermittent porphyria anesthesia animal experiment animal model animal tissue article blood controlled study dose time effect relation enzyme activity glucose metabolism heme synthesis intraperitoneal drug administration kidney liver mouse nonhuman priority journal Animal Disease Models, Animal Dose-Response Relationship, Drug Enzyme Activation Glucose Isoflurane Kidney Liver Mice Porphyria, Acute Intermittent Support, Non-U.S. Gov't Buzaleh, Ana María Batlle, Alcira María del Carmen Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria?
topic_facet	Acute Intermittent Porphyria Anesthesia Isoflurane 5 aminolevulinate synthase glucose heme oxygenase inhalation anesthetic agent isoflurane porphobilinogen deaminase porphobilinogenase unclassified drug acute intermittent porphyria anesthesia animal experiment animal model animal tissue article blood controlled study dose time effect relation enzyme activity glucose metabolism heme synthesis intraperitoneal drug administration kidney liver mouse nonhuman priority journal Animal Disease Models, Animal Dose-Response Relationship, Drug Enzyme Activation Glucose Isoflurane Kidney Liver Mice Porphyria, Acute Intermittent Support, Non-U.S. Gov't
description	The effects of isoflurane, a commonly used volatile anesthetic, on the activity of some haem enzymes in liver, kidney, and blood, and glucose content in liver and blood were studied. Mice were injected with different doses of the drug (0.5-6 mL/kg) and killed at varying intervals after injection (5-240 min). Within this dose range, optimal effects on alteration of haem metabolism were obtained at 2 mL/kg. The time-response profile for each enzyme was different. Blood porphobilinogenase (PBGase) and deaminase showed lower activities 20 min after anesthesia. This diminution coupled with the induction of δ-aminolevulinate synthetase activity observed soon after anesthesia (5 min) would fit well with the expected biochemical changes occurring in acute intermittent porphyria, indicating that this may be a suitable animal model for this disease. © 1992.
author	Buzaleh, Ana María Batlle, Alcira María del Carmen
author_facet	Buzaleh, Ana María Batlle, Alcira María del Carmen
author_sort	Buzaleh, Ana María
title	Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria?
title_short	Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria?
title_full	Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria?
title_fullStr	Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria?
title_full_unstemmed	Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria?
title_sort	administration of the anesthetic isoflurane to mice: a model for acute intermittent porphyria?
publishDate	1992
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10568719_v28_n4_p191_Buzaleh http://hdl.handle.net/20.500.12110/paper_10568719_v28_n4_p191_Buzaleh
work_keys_str_mv	AT buzalehanamaria administrationoftheanestheticisofluranetomiceamodelforacuteintermittentporphyria AT batllealciramariadelcarmen administrationoftheanestheticisofluranetomiceamodelforacuteintermittentporphyria
_version_	1768542327452729344

Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria?

Ejemplares similares