Parsing a sequence of brain activations at psychological times using fMRI
Identifying the sequence of computations which constitute a cognitive task is a fundamental problem in neuroscience. Here we show, using functional magnetic resonance imaging (fMRI), that we can parse, at the time scale of about 100 ms, the different stages of brain activations which compose a compl...
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2007
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10538119_v35_n2_p655_Sigman http://hdl.handle.net/20.500.12110/paper_10538119_v35_n2_p655_Sigman |
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paper:paper_10538119_v35_n2_p655_Sigman2023-06-08T16:03:03Z Parsing a sequence of brain activations at psychological times using fMRI Sigman, Mariano Additive factors Cognitive fMRI Language Sequences Timing oxygen adult analytic method article brain function brain region cingulate gyrus covariance frontal gyrus functional magnetic resonance imaging human information latent period motor activity motor system normal human oxygen blood level phonetics power spectrum priority journal reading sensory stimulation sensory system sequential analysis spectroscopy speech articulation stimulation supramarginal gyrus verbal behavior Adult Brain Cognition Humans Magnetic Resonance Imaging Task Performance and Analysis Time Factors Identifying the sequence of computations which constitute a cognitive task is a fundamental problem in neuroscience. Here we show, using functional magnetic resonance imaging (fMRI), that we can parse, at the time scale of about 100 ms, the different stages of brain activations which compose a complex sequential task. To identify timing information from the slow blood oxygen level-dependent (BOLD) signal response, we use a simple analytic method, based on periodic stimulation and an analysis of covariation of the spectral parameters (phase and power spectrum at the stimulation frequency) with the different experimental conditions. We implement this strategy in a sequential task, where the onset and duration of different stages are under experimental control. We are able to detect changes in onset latency and in the duration of the response, in an invariant fashion across different brain regions, and reconstruct the stream of activations consistent with five distinct stages of processing of the task. Sensory and motor clusters activate in the expected order and for the expected duration. The timing of sensory activations is more precise than the timing of motor activation. We also parse in time the reading-verbal network: visual extrastriate and phonological access regions (supramarginal gyrus) activate at the time of word presentation, while the inferior frontal gyrus, the anterior cingulate and the supplementary motor area are activated during the rehearsal period. © 2006 Elsevier Inc. All rights reserved. Fil:Sigman, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2007 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10538119_v35_n2_p655_Sigman http://hdl.handle.net/20.500.12110/paper_10538119_v35_n2_p655_Sigman |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Additive factors Cognitive fMRI Language Sequences Timing oxygen adult analytic method article brain function brain region cingulate gyrus covariance frontal gyrus functional magnetic resonance imaging human information latent period motor activity motor system normal human oxygen blood level phonetics power spectrum priority journal reading sensory stimulation sensory system sequential analysis spectroscopy speech articulation stimulation supramarginal gyrus verbal behavior Adult Brain Cognition Humans Magnetic Resonance Imaging Task Performance and Analysis Time Factors |
| spellingShingle |
Additive factors Cognitive fMRI Language Sequences Timing oxygen adult analytic method article brain function brain region cingulate gyrus covariance frontal gyrus functional magnetic resonance imaging human information latent period motor activity motor system normal human oxygen blood level phonetics power spectrum priority journal reading sensory stimulation sensory system sequential analysis spectroscopy speech articulation stimulation supramarginal gyrus verbal behavior Adult Brain Cognition Humans Magnetic Resonance Imaging Task Performance and Analysis Time Factors Sigman, Mariano Parsing a sequence of brain activations at psychological times using fMRI |
| topic_facet |
Additive factors Cognitive fMRI Language Sequences Timing oxygen adult analytic method article brain function brain region cingulate gyrus covariance frontal gyrus functional magnetic resonance imaging human information latent period motor activity motor system normal human oxygen blood level phonetics power spectrum priority journal reading sensory stimulation sensory system sequential analysis spectroscopy speech articulation stimulation supramarginal gyrus verbal behavior Adult Brain Cognition Humans Magnetic Resonance Imaging Task Performance and Analysis Time Factors |
| description |
Identifying the sequence of computations which constitute a cognitive task is a fundamental problem in neuroscience. Here we show, using functional magnetic resonance imaging (fMRI), that we can parse, at the time scale of about 100 ms, the different stages of brain activations which compose a complex sequential task. To identify timing information from the slow blood oxygen level-dependent (BOLD) signal response, we use a simple analytic method, based on periodic stimulation and an analysis of covariation of the spectral parameters (phase and power spectrum at the stimulation frequency) with the different experimental conditions. We implement this strategy in a sequential task, where the onset and duration of different stages are under experimental control. We are able to detect changes in onset latency and in the duration of the response, in an invariant fashion across different brain regions, and reconstruct the stream of activations consistent with five distinct stages of processing of the task. Sensory and motor clusters activate in the expected order and for the expected duration. The timing of sensory activations is more precise than the timing of motor activation. We also parse in time the reading-verbal network: visual extrastriate and phonological access regions (supramarginal gyrus) activate at the time of word presentation, while the inferior frontal gyrus, the anterior cingulate and the supplementary motor area are activated during the rehearsal period. © 2006 Elsevier Inc. All rights reserved. |
| author |
Sigman, Mariano |
| author_facet |
Sigman, Mariano |
| author_sort |
Sigman, Mariano |
| title |
Parsing a sequence of brain activations at psychological times using fMRI |
| title_short |
Parsing a sequence of brain activations at psychological times using fMRI |
| title_full |
Parsing a sequence of brain activations at psychological times using fMRI |
| title_fullStr |
Parsing a sequence of brain activations at psychological times using fMRI |
| title_full_unstemmed |
Parsing a sequence of brain activations at psychological times using fMRI |
| title_sort |
parsing a sequence of brain activations at psychological times using fmri |
| publishDate |
2007 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10538119_v35_n2_p655_Sigman http://hdl.handle.net/20.500.12110/paper_10538119_v35_n2_p655_Sigman |
| work_keys_str_mv |
AT sigmanmariano parsingasequenceofbrainactivationsatpsychologicaltimesusingfmri |
| _version_ |
1768541764171333632 |