Spatial object recognition memory formation under acute stress

Stress is known to have a critical impact on memory processes. In the present work, we focus on the effects of an acute stress event closely associated to an unrelated learning task. Here, we show that acute stress (elevated platform [EP] session) experienced 1 hr after a weak spatial object recogni...

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Detalles Bibliográficos
Publicado: 2018
Materias:
elevated platform
hippocampus
long-term memory
spatial object recognition
synaptic tagging
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10509631_v_n_p_LopesdaCunha
http://hdl.handle.net/20.500.12110/paper_10509631_v_n_p_LopesdaCunha
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_10509631_v_n_p_LopesdaCunha
record_format dspace
spelling paper:paper_10509631_v_n_p_LopesdaCunha2023-06-08T16:02:56Z Spatial object recognition memory formation under acute stress elevated platform hippocampus long-term memory spatial object recognition synaptic tagging Stress is known to have a critical impact on memory processes. In the present work, we focus on the effects of an acute stress event closely associated to an unrelated learning task. Here, we show that acute stress (elevated platform [EP] session) experienced 1 hr after a weak spatial object recognition (SOR) training, which only induces a short-term memory (STM), promoted the formation of SOR-long term memory (SOR-LTM) in rats. The effect induced by stress was dependent on the activation of glucocorticoid- and mineralocorticoid-receptors, brain-derived neurotrophic factor (BDNF) and protein synthesis in the dorsal hippocampus. In contrast, EP after a strong SOR impaired SOR-LTM probably by interfering with the use of necessary resources. Moreover, we show that the EP session before training induced anterograde interference, which it was not reversed by a subsequent exposure to an open field. Our findings provide novel insights into the impact of stress on LTM formation in rodents and they are discussed under the behavioral analogue of the synaptic tagging and capture hypothesis. © 2018 Wiley Periodicals, Inc. 2018 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10509631_v_n_p_LopesdaCunha http://hdl.handle.net/20.500.12110/paper_10509631_v_n_p_LopesdaCunha
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic elevated platform
hippocampus
long-term memory
spatial object recognition
synaptic tagging
spellingShingle elevated platform
hippocampus
long-term memory
spatial object recognition
synaptic tagging
Spatial object recognition memory formation under acute stress
topic_facet elevated platform
hippocampus
long-term memory
spatial object recognition
synaptic tagging
description Stress is known to have a critical impact on memory processes. In the present work, we focus on the effects of an acute stress event closely associated to an unrelated learning task. Here, we show that acute stress (elevated platform [EP] session) experienced 1 hr after a weak spatial object recognition (SOR) training, which only induces a short-term memory (STM), promoted the formation of SOR-long term memory (SOR-LTM) in rats. The effect induced by stress was dependent on the activation of glucocorticoid- and mineralocorticoid-receptors, brain-derived neurotrophic factor (BDNF) and protein synthesis in the dorsal hippocampus. In contrast, EP after a strong SOR impaired SOR-LTM probably by interfering with the use of necessary resources. Moreover, we show that the EP session before training induced anterograde interference, which it was not reversed by a subsequent exposure to an open field. Our findings provide novel insights into the impact of stress on LTM formation in rodents and they are discussed under the behavioral analogue of the synaptic tagging and capture hypothesis. © 2018 Wiley Periodicals, Inc.
title Spatial object recognition memory formation under acute stress
title_short Spatial object recognition memory formation under acute stress
title_full Spatial object recognition memory formation under acute stress
title_fullStr Spatial object recognition memory formation under acute stress
title_full_unstemmed Spatial object recognition memory formation under acute stress
title_sort spatial object recognition memory formation under acute stress
publishDate 2018
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10509631_v_n_p_LopesdaCunha
http://hdl.handle.net/20.500.12110/paper_10509631_v_n_p_LopesdaCunha
_version_ 1768541665235042304

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