Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens

Problem Fetal implantation enhances the production of essential growth factors such as LIF (leukaemia inhibitory factor), hence we investigated the contribution of maternal CD4 cells, activated by paternal or trophoblast antigens and its modulation by VIP (vasoactive intestinal peptide) and progeste...

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Autores principales:	Fraccaroli, Laura Virginia, Grasso, Esteban Nicolás, Pérez Leirós, Claudia, Ramhorst, Rosanna Elizabeth
Publicado:	2011
Materias:	Chemokines Recurrent spontaneous abortions Tolerance and pregnancy antigen gelatinase B leukemia inhibitory factor progesterone STAT3 protein vasoactive intestinal polypeptide article CD4+ T lymphocyte cell stimulation controlled study enzyme activity female female fertility fetoplacental unit human human cell inflammation lymphocytic infiltration nidation peripheral blood mononuclear cell priority journal protein synthesis recurrent abortion spontaneous abortion T lymphocyte trophoblast Abortion, Habitual Antigens CD4-Positive T-Lymphocytes Cells, Cultured Coculture Techniques Embryo Implantation Female Humans Immune Tolerance Leukemia Inhibitory Factor Leukocytes, Mononuclear Male Pregnancy Progesterone Trophoblasts Vasoactive Intestinal Peptide
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10467408_v65_n2_p133_Fraccaroli http://hdl.handle.net/20.500.12110/paper_10467408_v65_n2_p133_Fraccaroli
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_10467408_v65_n2_p133_Fraccaroli
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spelling	paper:paper_10467408_v65_n2_p133_Fraccaroli2023-06-08T16:01:14Z Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens Fraccaroli, Laura Virginia Grasso, Esteban Nicolás Pérez Leirós, Claudia Ramhorst, Rosanna Elizabeth Chemokines Recurrent spontaneous abortions Tolerance and pregnancy antigen gelatinase B leukemia inhibitory factor progesterone STAT3 protein vasoactive intestinal polypeptide article CD4+ T lymphocyte cell stimulation controlled study enzyme activity female female fertility fetoplacental unit human human cell inflammation lymphocytic infiltration nidation peripheral blood mononuclear cell priority journal protein synthesis recurrent abortion spontaneous abortion T lymphocyte trophoblast Abortion, Habitual Antigens CD4-Positive T-Lymphocytes Cells, Cultured Coculture Techniques Embryo Implantation Female Humans Immune Tolerance Leukemia Inhibitory Factor Leukocytes, Mononuclear Male Pregnancy Progesterone Trophoblasts Vasoactive Intestinal Peptide Problem Fetal implantation enhances the production of essential growth factors such as LIF (leukaemia inhibitory factor), hence we investigated the contribution of maternal CD4 cells, activated by paternal or trophoblast antigens and its modulation by VIP (vasoactive intestinal peptide) and progesterone.Method of study We performed co cultures of trophoblast cells (Swan 71 cell line) or paternal antigens and PBMCs from patients with recurrent spontaneous abortions (RSA) and fertile women.Result Fertile-CD4+LIF+ cells were increased by VIP and progesterone in response to paternal and trophoblast antigens. Also MMP 9 activity was decreased and pSTAT3/STAT3 ratio was increased. RSA patients have decreased levels of LIF expression which could not be modulated by VIP and progesterone and displayed a reduced number of endometrial infiltrated CD4+LIF+ cells compared with fertile women.Conclusion The decrease of CD4+LIF+ cells in RSA patients could be related with the exacerbated inflammatory response observed in the maternal fetal dialogue model. © 2010 John Wiley & Sons A/S. Fil:Fraccaroli, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Grasso, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Leirós, C.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ramhorst, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10467408_v65_n2_p133_Fraccaroli http://hdl.handle.net/20.500.12110/paper_10467408_v65_n2_p133_Fraccaroli
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Chemokines Recurrent spontaneous abortions Tolerance and pregnancy antigen gelatinase B leukemia inhibitory factor progesterone STAT3 protein vasoactive intestinal polypeptide article CD4+ T lymphocyte cell stimulation controlled study enzyme activity female female fertility fetoplacental unit human human cell inflammation lymphocytic infiltration nidation peripheral blood mononuclear cell priority journal protein synthesis recurrent abortion spontaneous abortion T lymphocyte trophoblast Abortion, Habitual Antigens CD4-Positive T-Lymphocytes Cells, Cultured Coculture Techniques Embryo Implantation Female Humans Immune Tolerance Leukemia Inhibitory Factor Leukocytes, Mononuclear Male Pregnancy Progesterone Trophoblasts Vasoactive Intestinal Peptide
spellingShingle	Chemokines Recurrent spontaneous abortions Tolerance and pregnancy antigen gelatinase B leukemia inhibitory factor progesterone STAT3 protein vasoactive intestinal polypeptide article CD4+ T lymphocyte cell stimulation controlled study enzyme activity female female fertility fetoplacental unit human human cell inflammation lymphocytic infiltration nidation peripheral blood mononuclear cell priority journal protein synthesis recurrent abortion spontaneous abortion T lymphocyte trophoblast Abortion, Habitual Antigens CD4-Positive T-Lymphocytes Cells, Cultured Coculture Techniques Embryo Implantation Female Humans Immune Tolerance Leukemia Inhibitory Factor Leukocytes, Mononuclear Male Pregnancy Progesterone Trophoblasts Vasoactive Intestinal Peptide Fraccaroli, Laura Virginia Grasso, Esteban Nicolás Pérez Leirós, Claudia Ramhorst, Rosanna Elizabeth Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens
topic_facet	Chemokines Recurrent spontaneous abortions Tolerance and pregnancy antigen gelatinase B leukemia inhibitory factor progesterone STAT3 protein vasoactive intestinal polypeptide article CD4+ T lymphocyte cell stimulation controlled study enzyme activity female female fertility fetoplacental unit human human cell inflammation lymphocytic infiltration nidation peripheral blood mononuclear cell priority journal protein synthesis recurrent abortion spontaneous abortion T lymphocyte trophoblast Abortion, Habitual Antigens CD4-Positive T-Lymphocytes Cells, Cultured Coculture Techniques Embryo Implantation Female Humans Immune Tolerance Leukemia Inhibitory Factor Leukocytes, Mononuclear Male Pregnancy Progesterone Trophoblasts Vasoactive Intestinal Peptide
description	Problem Fetal implantation enhances the production of essential growth factors such as LIF (leukaemia inhibitory factor), hence we investigated the contribution of maternal CD4 cells, activated by paternal or trophoblast antigens and its modulation by VIP (vasoactive intestinal peptide) and progesterone.Method of study We performed co cultures of trophoblast cells (Swan 71 cell line) or paternal antigens and PBMCs from patients with recurrent spontaneous abortions (RSA) and fertile women.Result Fertile-CD4+LIF+ cells were increased by VIP and progesterone in response to paternal and trophoblast antigens. Also MMP 9 activity was decreased and pSTAT3/STAT3 ratio was increased. RSA patients have decreased levels of LIF expression which could not be modulated by VIP and progesterone and displayed a reduced number of endometrial infiltrated CD4+LIF+ cells compared with fertile women.Conclusion The decrease of CD4+LIF+ cells in RSA patients could be related with the exacerbated inflammatory response observed in the maternal fetal dialogue model. © 2010 John Wiley & Sons A/S.
author	Fraccaroli, Laura Virginia Grasso, Esteban Nicolás Pérez Leirós, Claudia Ramhorst, Rosanna Elizabeth
author_facet	Fraccaroli, Laura Virginia Grasso, Esteban Nicolás Pérez Leirós, Claudia Ramhorst, Rosanna Elizabeth
author_sort	Fraccaroli, Laura Virginia
title	Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens
title_short	Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens
title_full	Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens
title_fullStr	Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens
title_full_unstemmed	Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens
title_sort	modulation of maternal lif producers t cells by trophoblast and paternal antigens
publishDate	2011
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10467408_v65_n2_p133_Fraccaroli http://hdl.handle.net/20.500.12110/paper_10467408_v65_n2_p133_Fraccaroli
work_keys_str_mv	AT fraccarolilauravirginia modulationofmaternallifproducerstcellsbytrophoblastandpaternalantigens AT grassoestebannicolas modulationofmaternallifproducerstcellsbytrophoblastandpaternalantigens AT perezleirosclaudia modulationofmaternallifproducerstcellsbytrophoblastandpaternalantigens AT ramhorstrosannaelizabeth modulationofmaternallifproducerstcellsbytrophoblastandpaternalantigens
_version_	1768544559492497408

Modulation of Maternal LIF Producers T Cells by Trophoblast and Paternal Antigens

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